Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study

Andrologia ◽  
2021 ◽  
Author(s):  
Osman Can ◽  
Lutfi Canat ◽  
Fatma Ceyla Eraldemir ◽  
Esra Acar ◽  
Funda Yildirim ◽  
...  
Keyword(s):  
Experimental Study ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Protective effect of dl-3n-butylphthalide preconditioning on focal cerebral ischaemia-reperfusion injury in rats

2013 ◽  
Vol 25 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Pei-Lei Zhang ◽  
Hai-Tao Lu ◽  
Jun-Gong Zhao ◽  
Ming-Hua Li
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Neurological Deficit ◽  
Cerebral Ischaemia ◽  
Sham Operation ◽  
Focal Cerebral Ischaemia ◽  
Vegf Expression ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Infarction Volume

ObjectiveTo investigate the effect of dl-3n-butylphthalide (NBP) on the protection of cerebral tissue and possible mechanism on ischaemia-reperfusion injury, and to find out whether NBP therapy can extend the reperfusion window in an experimental stroke model in rats.MethodsSeventy-two Sprague-Dawley rats were randomly divided into sham operation, ischaemia-reperfusion and ischaemia-reperfusion with NBP groups. Focal cerebral ischaemia was induced using the modified intraluminal thread method and maintained for 2, 3 or 4 h. The ischaemia-reperfusion group received reperfusion immediately after ischaemia-reperfusion. The NBP group received intraperitoneal injection of NBP immediately after ischaemia, followed by reperfusion. The sham operation group received only injection of physiological saline. The cerebral infarction volume and neurological deficit were analysed, and vascular endothelial growth factor (VEGF) expression in brain tissues was visualised by immunohistochemistry.ResultsNBP treatment caused a significant decrease in both infarction volume and neurological deficit compared with the ischaemia-reperfusion group at corresponding time points in each (p < 0.05). In the NBP group, the infarction volume and neurological deficit did not change with different ischaemia times. The expression of VEGF was significantly decreased in the ischaemia-reperfusion group compared with the sham group (p < 0.01), while this change was partly prevented in the NBP group (p < 0.01). The expression of VEGF in brain tissue in both the NBP and ischaemia-reperfusion groups gradually decreased when the ischaemic period was prolonged.ConclusionNBP treatment has a protective effect against cerebral ischaemia; this possible mechanism maybe related to the VEGF expression and may extend the reperfusion window for subsequent salvage of cerebral ischaemia by reperfusion.

Protective effect ofL-carnitine on renal ischaemia-reperfusion injury in the rat

2005 ◽  
Vol 23 (5) ◽  
pp. 369-369
Author(s):  
Orkan Ergün ◽  
İbrahim Ulman
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Renal Ischaemia ◽  
Ischaemia Reperfusion

scholarly journals Protection against renal ischaemia/reperfusion injury: A comparative experimental study of the effect of ischaemic preconditioning vs. postconditioning

2012 ◽  
Vol 10 (4) ◽  
pp. 418-424 ◽  
Author(s):  
Ahmed A. Shokeir ◽  
Abdelaziz M. Hussein ◽  
Amira Awadalla ◽  
Ahmed Samy ◽  
Azza Abdelaziz ◽  
...  
Keyword(s):  
Experimental Study ◽  
Reperfusion Injury ◽  
Ischaemic Preconditioning ◽  
Ischaemia Reperfusion Injury ◽  
Renal Ischaemia ◽  
Ischaemia Reperfusion

The protective effect of α-lipoic acid in experimental ovarian ischaemia-reperfusion injury

2007 ◽  
Vol 47 (6) ◽  
pp. 499-503 ◽  
Author(s):  
Emine COSAR ◽  
Figen Kır SAHIN ◽  
Gülengül KÖKEN ◽  
Hatice TOY ◽  
Kemal BASARALI ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Lipoic Acid ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Experimental study of the effects of deletion variant of hepatocyte growth factor on hepatic ischaemia-reperfusion injury

2000 ◽  
Vol 87 (1) ◽  
pp. 59-64 ◽  
Author(s):  
T. Ikegami ◽  
T. Nishizaki ◽  
H. Uchiyama ◽  
K. Hashimoto ◽  
K. Yanaga ◽  
...  
Keyword(s):  
Experimental Study ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Deletion Variant ◽  
Ischaemia Reperfusion ◽  
Hepatocyte Growth

Protective effect ofL-carnitine on testicular ischaemia–reperfusion injury in rats

2007 ◽  
Vol 25 (6) ◽  
pp. 611-618 ◽  
Author(s):  
Dikmen Dokmeci ◽  
Mustafa Inan ◽  
Umit Nusret Basaran ◽  
Omer Yalcin ◽  
Nurettin Aydogdu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Protective effect of telomerase-based 16-mer peptide vaccine (GV1001) on inferior epigastric island skin flap survivability in ischaemia-reperfusion injury rat model

2016 ◽  
Vol 51 (3) ◽  
pp. 210-216 ◽  
Author(s):  
Yung Ki Lee ◽  
Beta Subakti Nata’atmaja ◽  
Byung Hwi Kim ◽  
Chang Sik Pak ◽  
Chan Yeong Heo
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Skin Flap ◽  
Peptide Vaccine ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion
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