Verbal and spatial memory spans in mild cognitive impairment

Author(s):  
Massimo De Tollis ◽  
Maria Stefania De Simone ◽  
Roberta Perri ◽  
Lucia Fadda ◽  
Carlo Caltagirone ◽  
...  
2021 ◽  
Vol 79 (1) ◽  
pp. 95-116
Author(s):  
Cosimo Tuena ◽  
Valentina Mancuso ◽  
Chiara Stramba-Badiale ◽  
Elisa Pedroli ◽  
Marco Stramba-Badiale ◽  
...  

Background: Spatial navigation is the ability to estimate one’s position on the basis of environmental and self-motion cues. Spatial memory is the cognitive substrate underlying navigation and relies on two different reference frames: egocentric and allocentric. These spatial frames are prone to decline with aging and impairment is even more pronounced in Alzheimer’s disease (AD) or in mild cognitive impairment (MCI). Objective: To conduct a systematic review of experimental studies investigating which MCI population and tasks are used to evaluate spatial memory and how allocentric and egocentric deficits are impaired in MCI after navigation. Methods: PRISMA and PICO guidelines were applied to carry out the systematic search. Down and Black checklist was used to assess methodological quality. Results: Our results showed that amnestic MCI and AD pathology are the most investigated typologies; both egocentric and allocentric memory are impaired in MCI individuals, and MCI due to AD biomarkers has specific encoding and retrieval impairments; secondly, spatial navigation is principally investigated with the hidden goal task (virtual and real-world version), and among studies involving virtual reality, the privileged setting consists of non-immersive technology; thirdly, despite subtle differences, real-world and virtual versions showed good overlap for the assessment of MCI spatial memory. Conclusion: Considering that MCI is a subclinical entity with potential risk for conversion to dementia, investigating spatial memory deficits with navigation tasks might be crucial to make accurate diagnosis and rehabilitation.


2009 ◽  
Vol 16 (1) ◽  
pp. 200-204 ◽  
Author(s):  
ROY P.C. KESSELS ◽  
STEFAN RIJKEN ◽  
LIESBETH W.A. JOOSTEN-WEYN BANNINGH ◽  
NELLEKE VAN SCHUYLENBORGH-VAN ES ◽  
MARCEL G.M. OLDE RIKKERT

AbstractMemory for object locations, as part of spatial memory function, has rarely been studied in patients with Alzheimer dementia (AD), while studies in patients with Mild Cognitive Impairment (MCI) patients are lacking altogether. The present study examined categorical spatial memory function using the Location Learning Test (LLT) in MCI patients (n = 30), AD patients (n = 30), and healthy controls (n = 40). Two scoring methods were compared, aimed at disentangling positional recall (location irrespective of object identity) and object-location binding. The results showed that AD patients performed worse than the MCI patients on the LLT, both on recall of positional information and on recall of the locations of different objects. In addition, both measures could validly discriminate between AD and MCI patients. These findings are in agreement with the notion that visual cued-recall tests may have better diagnostic value than traditional (verbal) free-recall tests in the assessment of patients with suspected MCI or AD. (JINS, 2010, 16, 200–204.)


2009 ◽  
Vol 5 (4S_Part_12) ◽  
pp. P357-P357
Author(s):  
Kathryn V. Papp ◽  
Peter J. Snyder ◽  
Paul Maruff ◽  
Robert H. Pietrzak ◽  
Jennifer Bartkowiak ◽  
...  

Hippocampus ◽  
2015 ◽  
Vol 25 (8) ◽  
pp. 939-951 ◽  
Author(s):  
Kuven Moodley ◽  
Ludovico Minati ◽  
Valeria Contarino ◽  
Sara Prioni ◽  
Ruth Wood ◽  
...  

Neurology ◽  
2005 ◽  
Vol 64 (12) ◽  
pp. 2063-2068 ◽  
Author(s):  
M. M. Cherrier ◽  
A. M. Matsumoto ◽  
J. K. Amory ◽  
S. Asthana ◽  
W. Bremner ◽  
...  

2011 ◽  
Vol 7 ◽  
pp. S539-S540
Author(s):  
Reiko Koide ◽  
Kazuhiro Ishii ◽  
Hikari Kinjo ◽  
Yasushi Tomidokoro ◽  
Tohoru Takeda ◽  
...  

2021 ◽  
Vol 11 (10) ◽  
pp. 1350
Author(s):  
Jackie M. Poos ◽  
Ineke J. M. van der van der Ham ◽  
Anna E. Leeuwis ◽  
Yolande A. L. Pijnenburg ◽  
Wiesje M. van der van der Flier ◽  
...  

Background: Impairment in navigation abilities and object location memory are often seen in early-stage Alzheimer’s Disease (AD), yet these constructs are not included in standard neuropsychological assessment. We investigated the differential ability of a short digital spatial memory test in mild AD dementia and mild cognitive impairment (MCI). Methods: 21 patients with AD dementia (66.9 ± 6.9; 47% female), 22 patients with MCI (69.6 ± 8.3; 46% female) and 21 patients with subjective cognitive decline (SCD) (62.2 ± 8.9; 48% female) from the Amsterdam Dementia Cohort performed the Object Location Memory Test (OLMT), consisting of a visual perception and memory trial, and the Virtual Tübingen (VT) test, consisting of a scene recognition, route continuation, route ordering and distance comparison task. The correlations with other cognitive domains were examined. Results: Patients with mild AD dementia (Z: −2.51 ± 1.15) and MCI (Z: −1.81 ± 0.92) performed worse than participants with SCD (Z: 0.0 ± 1.0) on the OLMT. Scene recognition and route continuation were equally impaired in patients with AD dementia (Z: −1.14 ± 0.73; Z: −1.44 ± 1.13) and MCI (Z: −1.37 ± 1.25; Z: −1.21 ± 1.07). Route ordering was only impaired in patients with MCI (Z: −0.82 ± 0.78). Weak to moderate correlations were found between route continuation and memory (r(64) = 0.40, p < 0.01), and between route ordering and attention (r(64) = 0.33, p < 0.01), but not for the OLMT. Conclusion: A short digital spatial memory test battery was able to detect object location memory and navigation impairment in patients with mild AD dementia and MCI, highlighting the value of incorporating such a test battery in standard neuropsychological assessment.


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