scholarly journals A new microdialysis probe for continuous lactate measurement during fetal monitoring: Proof of concept in an animal model

2020 ◽  
Vol 99 (10) ◽  
pp. 1411-1416
Author(s):  
Froukje Tigchelaar ◽  
Henk Groen ◽  
Magnus Westgren ◽  
Kirsten D. Huinink ◽  
Thomas Cremers ◽  
...  
Keyword(s):  
Animal Model ◽  
Fetal Monitoring ◽  
Proof Of Concept ◽  
Microdialysis Probe ◽  
Lactate Measurement

An animal model of deep brain stimulation for treating tinnitus: A proof of concept study

2017 ◽  
Vol 128 (5) ◽  
pp. 1213-1222 ◽  
Author(s):  
Syed F. Ahsan ◽  
Hao Luo ◽  
Jinsheng Zhang ◽  
Eric Kim ◽  
Yong Xu
Keyword(s):  
Animal Model ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Proof Of Concept ◽  
Concept Study ◽  
Deep Brain

scholarly journals 249 CHANGES IN TUMOR STIFFNESS FOR EARLY PREDICTION OF TUMOR RESPONSE TO SORAFENIB: A PROOF-OF-CONCEPT STUDY WITH ELASTOSONOGRAPHY IN AN ANIMAL MODEL OF HEPATOCELLULAR CARCINOMA (HCC)

2011 ◽  
Vol 54 ◽  
pp. S102-S103
Author(s):  
V. Salvatore ◽  
M. Baron Toaldo ◽  
S. Marinelli ◽  
C. Palamà ◽  
L. Gramantieri ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Animal Model ◽  
Tumor Response ◽  
Early Prediction ◽  
Proof Of Concept ◽  
Concept Study ◽  
Tumor Stiffness

Proof Of Concept: Mid-Frequency Ventilation In A Neonatal And Pediatric Live Animal Model

2010 ◽  
Author(s):  
Eduardo Mireles-Cabodevila ◽  
Shirely Holt ◽  
Tracy Thurman ◽  
Robert Chatburn ◽  
Mark Heulitt
Keyword(s):  
Animal Model ◽  
Proof Of Concept ◽  
Live Animal ◽  
Frequency Ventilation

scholarly journals Enhanced Intradermal Delivery of Nanosuspensions of Antifilariasis Drugs Using Dissolving Microneedles: A Proof of Concept Study

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 346 ◽  
Author(s):  
Permana ◽  
McCrudden ◽  
Donnelly
Keyword(s):  
Animal Model ◽  
Proof Of Concept ◽  
Porcine Skin ◽  
Lymphatic Uptake ◽  
Dissolving Microneedles ◽  
Intradermal Delivery ◽  
Suitable Animal Model ◽  
Future Work ◽  
Delivery Approach

Conventional oral administration of antifilariasis drugs results in nonspecific targeting of the drugs and the intradermal delivery of nanoparticles with sizes of <100 nm could be used to improve lymphatic uptake. This study investigated the combination of nanosuspension and dissolving microneedles (MN-NS) as an alternative intradermal delivery approach for the delivery of antifilariasis drugs, namely doxycycline, albendazole, and ivermectin. NS were fabricated and optimized using a bottom-up technique. The NS were then incorporated into the MN arrays. The optimized NS were <100 nm in diameter. Furthermore, MN-NS had suitable mechanical strength and insertion capabilities. The dermatokinetic study revealed that the delivery of drugs into the dermis of excised neonatal porcine skin by MNs was significantly higher than that from a needle-free patch, with 29.29 ± 4.65%, 31.54 ± 5.35%, and 34.54 ± 4.98% of doxycycline, albendazole sulfoxide, and ivermectin retained in the dermis after 24 h. The results presented here serve as proof of concept for the significant enhancement of drug retention times in the dermis, following their formulation into NS and delivery via MN. Leading on from these studies, future work must investigate in vivo lymphatic pharmacokinetic profiling of drugs formulated into NS, in a suitable animal model.

Mesenchymal stem cell derived exosomes in the treatment of synovitis: proof of concept in large animal model

2016 ◽  
Vol 33 (3) ◽  
pp. 409
Author(s):  
F. Javier Vela González ◽  
Francisco M. Sánchez-Margallo ◽  
Angelo Tapia-Araya ◽  
Rebeca Blázquez ◽  
Verónica Álvarez ◽  
...  
Keyword(s):  
Animal Model ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Large Animal Model ◽  
Large Animal ◽  
Proof Of Concept

Sa1613 A Pilot Proof-of-Concept Study of a Modified Device for One-Step EUS-Guided Biliary Drainage in a New Experimental Biliary Dilatation Animal Model

2014 ◽  
Vol 79 (5) ◽  
pp. AB274
Author(s):  
Tae Hoon Lee ◽  
Do Hyun Park ◽  
Joon Hyuk Choi ◽  
Sang Soo Lee ◽  
Dong Wan Seo ◽  
...  
Keyword(s):  
Animal Model ◽  
Biliary Drainage ◽  
Proof Of Concept ◽  
Concept Study ◽  
Biliary Dilatation ◽  
One Step

OP04.01: Magnetic resonance determiation of pH, lactates and oxymetry in animal model of acute fetal distress: Towards new ways of fetal monitoring?

2008 ◽  
Vol 32 (3) ◽  
pp. 321-321
Author(s):  
O. Ami ◽  
G. Bielicki ◽  
C. Keller ◽  
J. M. Bonny ◽  
L. Boyer ◽  
...  
Keyword(s):  
Animal Model ◽  
Magnetic Resonance ◽  
Fetal Monitoring ◽  
Fetal Distress

scholarly journals Proof-of-Concept Studies for Marker-Based Ultrasound Doppler Analysis of Microvascular Anastomoses in a Modified Large Animal Model

2015 ◽  
Vol 32 (04) ◽  
pp. 251-255 ◽  
Author(s):  
Devin Coon ◽  
Lei Chen ◽  
Emad Boctor ◽  
Jerry Prince ◽  
Branko Bojovic
Keyword(s):  
Animal Model ◽  
Large Animal Model ◽  
Large Animal ◽  
Proof Of Concept ◽  
Ultrasound Doppler ◽  
Doppler Analysis

scholarly journals Changes in Tumor Stiffness for Early Prediction of Tumor Response to Sorafenib: A Proof-of-Concept Study with Elastosonography in an Animal Model of Hepatocellular Carcinoma (HCC)

2011 ◽  
Vol 37 (8) ◽  
pp. S21
Author(s):  
V. Salvatore ◽  
S. Marinelli ◽  
M. Baron Toaldo ◽  
C. Palamà ◽  
L. Gramantieri ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Animal Model ◽  
Tumor Response ◽  
Early Prediction ◽  
Proof Of Concept ◽  
Concept Study ◽  
Tumor Stiffness
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