A Dermal Equivalent Engineered with TGF-β3 Expressing Bone Marrow Stromal Cells and Amniotic Membrane: Cosmetic Healing of Full-Thickness Skin Wounds in Rats

2016 ◽  
Vol 40 (12) ◽  
pp. E266-E279 ◽  
Author(s):  
Ali Samadikuchaksaraei ◽  
Ahmad Mehdipour ◽  
Mehryar Habibi Roudkenar ◽  
Javad Verdi ◽  
Mohammad Taghi Joghataei ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Amniotic Membrane ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Skin Wounds ◽  
Full Thickness ◽  
Dermal Equivalent ◽  
Full Thickness Skin ◽  
Thickness Skin

Evaluation of autologous bone marrow-derived nucleated cells for healing of full-thickness skin wounds in rabbits

2010 ◽  
Vol 7 (4) ◽  
pp. 249-260 ◽  
Author(s):  
BM Borena ◽  
AM Pawde ◽  
HP Aithal ◽  
P Kinjavdekar ◽  
Rajendra Singh ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Autologous Bone Marrow ◽  
Skin Wounds ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Autologous Bone

scholarly journals Hair Follicle Morphogenesis in the Treatment of Mouse Full-Thickness Skin Defects Using Composite Human Acellular Amniotic Membrane and Adipose Derived Mesenchymal Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Wu Minjuan ◽  
Xiong Jun ◽  
Shao Shiyun ◽  
Xu Sha ◽  
Ni Haitao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hair Follicle ◽  
Amniotic Membrane ◽  
Functional Restoration ◽  
Skin Wounds ◽  
Full Thickness ◽  
Skin Defects ◽  
Full Thickness Skin ◽  
Thickness Skin

Early repair of skin injury and maximal restoration of the function and appearance have become important targets of clinical treatment. In the present study, we observed the healing process of skin defects in nude mice and structural characteristics of the new skin after transplantation of isolated and cultured adipose derived mesenchymal stem cells (ADMSCs) onto the human acellular amniotic membrane (AAM). The result showed that ADMSCs were closely attached to the surface of AAM and grew well 24 h after seeding. Comparison of the wound healing rate at days 7, 14, and 28 after transplantation showed that ADMSCs seeded on AAM facilitated the healing of full-thickness skin wounds more effectively as compared with either hAM or AAM alone, indicating that ADMSCs participated in skin regeneration. More importantly, we noticed a phenomenon of hair follicle development during the process of skin repair. Composite ADMSCs and AAM not only promoted the healing of the mouse full-thickness defects but also facilitated generation of the appendages of the affected skin, thus promoting restoration of the skin function. Our results provide a new possible therapy idea for the treatment of skin wounds with respect to both anatomical regeneration and functional restoration.

scholarly journals Effect of Bone Marrow Derived Mesenchymal Stem Cells on Healing of Induced Full-Thickness Skin Wounds in Albino Rat

2013 ◽  
Vol 6 (1) ◽  
pp. 12-25 ◽  
Author(s):  
Hend Shafik Basiouny ◽  
Nagla Mohamed Salama ◽  
Zeinab Mohamed El Maadawi ◽  
Eman Abas Farag
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Skin Wounds ◽  
Full Thickness ◽  
Albino Rat ◽  
Full Thickness Skin ◽  
Thickness Skin

Glucocorticoid exposure reduces expression of sclerostin in bone marrow stromal cells

2013 ◽  
Author(s):  
Sylvia Thiele ◽  
Alexander Rauch ◽  
Jan P Tuckermann ◽  
Lorenz C Hofbauer ◽  
Martina Rauner
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells
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