scholarly journals Management of patent ductus arteriosus in very premature infants: An ongoing conundrum

2021 ◽  
Author(s):  
T. Allen Merritt

2006 ◽  
Vol 81 (1) ◽  
pp. 231-234 ◽  
Author(s):  
Sophie Jaillard ◽  
Benoît Larrue ◽  
Thameur Rakza ◽  
Eric Magnenant ◽  
Henri Warembourg ◽  
...  


Author(s):  
Julien I.E. Hoffman

BACKGROUND: The benefits of closing the ductus arteriosus in very preterm infants have not been convincingly shown in numerous clinical trials. Because a large untreated ductus arteriosus can cause death from congestive heart failure in infants born at term, we need to explain why this might not occur in premature infants born at <28 weeks’ gestation. METHODS: Based on information in the literature, I have commented on the possible relationship between the pulmonary vasculature and the shunt through the patent ductus arteriosus. RESULTS: Many of these infants have bronchopulmonary dysplasia, in which animal and human studies have shown a reduced number of capillaries and small pulmonary arteries as well as reduction in vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (PECAM-1). Both of these import angiogenic factors. Some who do not have bronchopulmonary dysplasia may have a restricted pulmonary vascular bed. CONCLUSIONS: The increased pulmonary vascular resistance in very premature infants may restrict pulmonary blood flow even if the ductus is large, thus reducing the urgency for ductus closure.





2014 ◽  
Vol 4 (1(11)) ◽  
pp. 13-16
Author(s):  
I.A. Aksenova ◽  
A.I. Kvasha ◽  
B.M. B.M. Todurov ◽  
T.U. Babich ◽  
A.G. Sidorov ◽  
...  


Author(s):  
Ruchira Garg ◽  
Evan Zahn ◽  
Shyam Sathanandam ◽  
Jason N. Johnson




2001 ◽  
Vol 138 (2) ◽  
pp. 205-211 ◽  
Author(s):  
Bart Van Overmeire ◽  
Hilde Van de Broek ◽  
Paul Van Laer ◽  
Joost Weyler ◽  
Piet Vanhaesebrouck


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