Oral Ibuprofen in Early Curative Closure of Patent Ductus Arteriosus in Very Premature Infants

2007 ◽  
Vol 24 (6) ◽  
pp. 339-345 ◽  
Author(s):  
Ahmed Cherif ◽  
Sami Jabnoun ◽  
Naima Khrouf
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Oral Ibuprofen ◽  
Very Premature Infants ◽  
Patent Ductus

Consequences of Delayed Surgical Closure of Patent Ductus Arteriosus in Very Premature Infants

2006 ◽  
Vol 81 (1) ◽  
pp. 231-234 ◽  
Author(s):  
Sophie Jaillard ◽  
Benoît Larrue ◽  
Thameur Rakza ◽  
Eric Magnenant ◽  
Henri Warembourg ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Surgical Closure ◽  
Very Premature Infants ◽  
Patent Ductus

Interaction between pulmonary vasculature and the patent ductus arteriosus in very premature infants

2020 ◽  
pp. 1-3
Author(s):  
Julien I.E. Hoffman
Keyword(s):  
Patent Ductus Arteriosus ◽  
Bronchopulmonary Dysplasia ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Pulmonary Arteries ◽  
Pulmonary Vasculature ◽  
Very Preterm Infants ◽  
Platelet Endothelial Cell Adhesion ◽  
Very Premature Infants ◽  
Patent Ductus

BACKGROUND: The benefits of closing the ductus arteriosus in very preterm infants have not been convincingly shown in numerous clinical trials. Because a large untreated ductus arteriosus can cause death from congestive heart failure in infants born at term, we need to explain why this might not occur in premature infants born at <28 weeks’ gestation. METHODS: Based on information in the literature, I have commented on the possible relationship between the pulmonary vasculature and the shunt through the patent ductus arteriosus. RESULTS: Many of these infants have bronchopulmonary dysplasia, in which animal and human studies have shown a reduced number of capillaries and small pulmonary arteries as well as reduction in vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (PECAM-1). Both of these import angiogenic factors. Some who do not have bronchopulmonary dysplasia may have a restricted pulmonary vascular bed. CONCLUSIONS: The increased pulmonary vascular resistance in very premature infants may restrict pulmonary blood flow even if the ductus is large, thus reducing the urgency for ductus closure.

scholarly journals Repeated Courses of Oral Ibuprofen in Premature Infants with Patent Ductus Arteriosus: Efficacy and Safety

2017 ◽  
Vol 58 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Haşim Olgun ◽  
Naci Ceviz ◽  
İbrahim Kartal ◽  
İbrahim Caner ◽  
Mehmet Karacan ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Efficacy And Safety ◽  
Oral Ibuprofen ◽  
Patent Ductus

scholarly journals Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus

2017 ◽  
Vol 46 (2) ◽  
pp. 811-818 ◽  
Author(s):  
Manar Al-lawama ◽  
Iyad Alammori ◽  
Tariq Abdelghani ◽  
Eman Badran
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Primary Closure ◽  
Ductus Arteriosus ◽  
Randomized Study ◽  
Inclusion Criteria ◽  
Short Term ◽  
Significant Difference ◽  
Oral Ibuprofen ◽  
Patent Ductus

Objective This study was performed to investigate the safety and efficacy of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods Premature infants with PDA with a gestational age of ≤32 weeks or birth weight of ≤1500 g were included in this randomized study. Results A total of 120 premature infants fulfilled the inclusion criteria. Of these 120 infants, 34 fulfilled the treatment criteria and 22 were finally randomized. We found no significant difference in the mortality or primary closure rates between the two groups. We also found no significant difference in the short-term neonatal outcomes. Conclusions Either oral paracetamol or oral ibuprofen can be used safely and effectively to treat PDA in premature infants.

scholarly journals Effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus in premature infants

Medicine ◽  
2018 ◽  
Vol 97 (37) ◽  
pp. e12206 ◽  
Author(s):  
Yanjie Ding ◽  
Xuan Wang ◽  
Yanqiu Wu ◽  
Hui Li ◽  
Jiaju Xu ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Closure Rate ◽  
Oral Ibuprofen ◽  
Patent Ductus
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