Spindle Cell Tumors of the Pleura and the Peritoneum: Pathologic Diagnosis and Updates

Apmis ◽  
2021 ◽  
Author(s):  
Baris Boyraz ◽  
Yin P. Hung
Keyword(s):  
Spindle Cell ◽  
Pathologic Diagnosis ◽  
Spindle Cell Tumors

Three Types of Spindle Cell Tumors of the Pleura

1988 ◽  
Vol 12 (10) ◽  
pp. 747-753 ◽  
Author(s):  
Darryl Carter ◽  
Christopher N. Otis
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Tumors

scholarly journals Spindle cell tumors resected from male patients with germ cell tumors. A clinicopathologic study of 14 cases

Cancer ◽  
1990 ◽  
Vol 65 (1) ◽  
pp. 148-156 ◽  
Author(s):  
Thomas M. Ulbright ◽  
Helen Michael ◽  
Patrick J. Loehrer ◽  
John P. Donohue
Keyword(s):  
Germ Cell ◽  
Spindle Cell ◽  
Germ Cell Tumors ◽  
Clinicopathologic Study ◽  
Male Patients ◽  
Spindle Cell Tumors

Solitary Fibrous Tumor of the Prostate

2001 ◽  
Vol 125 (2) ◽  
pp. 274-277
Author(s):  
Michael R. Pins ◽  
Steven C. Campbell ◽  
William B. Laskin ◽  
Karen Steinbronn ◽  
Daniel P. Dalton
Keyword(s):  
Mitotic Activity ◽  
Solitary Fibrous Tumor ◽  
Growth Pattern ◽  
Spindle Cell ◽  
Cytologic Atypia ◽  
Diffuse Growth ◽  
High Mitotic Activity ◽  
Spindle Cell Tumors ◽  
Fibrous Tumor

Abstract We report 2 cases of solitary fibrous tumor of the prostate. Histologically, both tumors demonstrated a multipatterned architecture with varying degrees of collagenization and hemangiopericytoma-like foci, and both were composed of CD34-immunopositive spindled cells that insinuated themselves between strips of collagen. The tumor in case 1 was well circumscribed and showed minimal mitotic activity or pleomorphism, whereas the tumor in case 2 was more cellular, less collagenous, had a more diffuse growth pattern, and exhibited cytologic atypia and high mitotic activity. Prostatic solitary fibrous tumor must be distinguished from other spindle cell tumors reported to occur in the prostate. To our knowledge, these cases represent only the fifth and sixth reported cases of prostatic solitary fibrous tumor.

Pediatric Spindle Cell Tumors

2019 ◽  
pp. 101-134
Author(s):  
Cheryl M. Coffin ◽  
Rita Alaggio
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Tumors

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: A Consensus Statement from the International Mesothelioma Interest Group

2009 ◽  
Vol 133 (8) ◽  
pp. 1317-1331 ◽  
Author(s):  
Aliya N. Husain ◽  
Thomas V. Colby ◽  
Nelson G. Ordóñez ◽  
Thomas Krausz ◽  
Alain Borczuk ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Interest Group ◽  
Malignant Mesothelioma ◽  
Consensus Statement ◽  
Spindle Cell ◽  
Cytologic Diagnosis ◽  
Pathologic Diagnosis ◽  
Practical Guidelines ◽  
Colonic Adenocarcinomas ◽  
Sarcomatoid Mesothelioma

Abstract Context.—Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. Objective.—To develop practical guidelines for the pathologic diagnosis of MM. Data Sources.—A pathology panel was convened at the International Mesothelioma Interest Group biennial meeting (October 2006). Pathologists with an interest in the field also contributed after the meeting. Conclusions.—There was consensus opinion regarding (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid mesothelioma, (7) use of molecular markers in the differential diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM. Immunohistochemical panels are integral to the diagnosis of MM, but the exact makeup of panels used is dependent on the differential diagnosis and on the antibodies available in a given laboratory. Immunohistochemical panels should contain both positive and negative markers. The International Mesothelioma Interest Group recommends that markers have either sensitivity or specificity greater than 80% for the lesions in question. Interpretation of positivity generally should take into account the localization of the stain (eg, nuclear versus cytoplasmic) and the percentage of cells staining (>10% is suggested for cytoplasmic membranous markers). These guidelines are meant to be a practical reference for the pathologist.

Spindle Cell Tumors of Adults

2013 ◽  
pp. 13-93
Author(s):  
Adrián Mariño-Enríquez ◽  
Louis Guillou ◽  
Jason L. Hornick
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Tumors

Spindle cell tumors of bone and soft tissue in infants and children

2013 ◽  
pp. 23-40
Author(s):  
Lester J. Layfield ◽  
Carlos W. Bedrossian ◽  
Julia R. Crim ◽  
Lucio Palombini
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Infants And Children ◽  
Tumors Of Bone ◽  
Spindle Cell Tumors ◽  
In Infants And Children

SMOOTH AND SKELETAL MUSCLE MYOSINS IN SPINDLE CELL TUMORS OF SOFT TISSUE

1985 ◽  
Vol 35 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Takashi Saku ◽  
Nobuo Tsuda ◽  
Masanobu Anami ◽  
Haruo Okabe
Keyword(s):  
Skeletal Muscle ◽  
Soft Tissue ◽  
Spindle Cell ◽  
Spindle Cell Tumors

scholarly journals Immunohistochemical analysis of pigment cell tumors in two cyprinid species

2019 ◽  
Vol 31 (5) ◽  
pp. 788-791
Author(s):  
Wesley C. Siniard ◽  
Matthew F. Sheley ◽  
Brittany N. Stevens ◽  
Christine A. Parker-Graham ◽  
Melissa A. Roy ◽  
...  
Keyword(s):  
Internal Control ◽  
Spindle Cell ◽  
Pigment Cell ◽  
Immunohistochemical Analysis ◽  
Pigment Cells ◽  
Semiquantitative Analysis ◽  
Cellular Origin ◽  
Immunohistochemical Assay ◽  
Cyprinid Species ◽  
Spindle Cell Tumors

Pigment cell tumors, also known as chromatophoromas, are cutaneous spindle cell neoplasms originating from pigment cells (chromatophores) in the dermis of teleosts, amphibians, and reptiles. Chromatophoromas share similar histologic morphology to other spindle cell tumors and are not always pigmented. Therefore, immunohistochemical analysis may be useful in distinguishing these neoplasms from tumors of other cellular origin when poorly pigmented. We performed 3 immunohistochemistry assays (PNL-2, melan A, and SOX10) on 8 cutaneous neoplasms from 8 teleosts diagnosed as chromatophoromas based on histologic morphology. Semiquantitative analysis of immunoreactivity was evaluated on each immunohistochemical assay using a 0–3 scale. PNL-2 exhibited mild-to-moderate (1 or 2) immunoreactivity in 7 of the cases, and resident chromatophores (internal control) were also immunoreactive in these cases. Melan A exhibited mild-to-moderate (1 or 2) immunoreactivity in 4 cases (and with resident chromatophores in these cases); SOX10 was not immunoreactive in any cases. Our results indicate that PNL-2 may be a useful marker in teleosts to distinguish tumors of chromatophore origin. Melan A could also be useful, but appears to be less sensitive, and SOX10 is likely not a useful marker for these neoplasms in teleosts.

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