scholarly journals Commentary: fibroblast growth factor 19 in patients with bile acid diarrhoea

2013 ◽  
Vol 38 (10) ◽  
pp. 1320-1321 ◽  
Author(s):  
M. Camilleri ◽  
A. Acosta
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

scholarly journals OC-036 Stimulated expression of ileal fibroblast growth factor 19 by bile acids is impaired in patients with primary and secondary bile acid diarrhoea

Gut ◽  
2015 ◽  
Vol 64 (Suppl 1) ◽  
pp. A19.1-A19
Author(s):  
JD Nolan ◽  
RN Appleby ◽  
GK Madhan ◽  
IM Johnston ◽  
K Sarah ◽  
...  
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Secondary Bile Acid ◽  
Fibroblast Growth Factor 19

scholarly journals 770 Evaluation of Fibroblast Growth Factor 19 and 7α-Hydroxy-4-Cholesten-3-One in the Diagnosis of Bile Acid Diarrhea

2010 ◽  
Vol 138 (5) ◽  
pp. S-107
Author(s):  
Sanjeev S. Pattni ◽  
Gordon Brydon ◽  
Tracy Dew ◽  
Julian R. Walters
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

Chenodeoxycholic acid stimulated fibroblast growth factor 19 response - a potential biochemical test for bile acid diarrhoea.

2017 ◽  
Vol 45 (11) ◽  
pp. 1433-1442 ◽  
Author(s):  
C. Borup ◽  
S. Wildt ◽  
J. J. Rumessen ◽  
P. N. Bouchelouche ◽  
J. Graff ◽  
...  
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Chenodeoxycholic Acid ◽  
Biochemical Test ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

scholarly journals The role of fibroblast growth factor 19 in pathogenesis of bile acid diarrhea of the patients who underwent cholecystectomy

2021 ◽  
Vol 93 (2) ◽  
pp. 174-178
Author(s):  
L. Кh. Indeykina ◽  
Е. А. Sabelnikova ◽  
G. G. Varvanina ◽  
S. U. Silvestrova ◽  
А. V. Smirnova ◽  
...  
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Blood Serum ◽  
Fibroblast Growth Factor ◽  
Chronic Diarrhea ◽  
Control Group ◽  
Fibroblast Growth ◽  
Daily Excretion ◽  
Fibroblast Growth Factor 19

The occurrence of chronic diarrhea after cholecystectomy (CCY) has been described by many researchers. However, the main mechanisms of the development of this diarrhea are not fully understood. Supposed that dysregulation of the bile acids (ВA) absorption in the ileum is played a significant role in the development of diarrhea syndrome. Aim. To determine the role of the fibroblast growth factor 19 (FGF19) level in the serum and BA concentration in feces in pathogenesis of bile acid diarrhea (ВАD) in patients after CCY. Materials and methods. Sixty-one patients were examined at various times after CCY: 30 patients with chronic diarrhea that appeared after CCY (group 1) and 31 patients with normal stools (group 2). In all patients, the level of FGF19 in the blood serum, and the daily excretion of BA in the feces were studied. The control group consisted of 28 healthy individuals. Results. In the 1st group we found lower concentrations of FGF19 in the blood serum 86.2 ng/ml (67.8; 117.8) compared with concentrations in the 2nd group 259 ng/ml (170.6; 318.8), p0.001. The daily excretion of bile acids with feces in the 1st group was 657.4 mg/day (524.6; 830.1), which was twice more than in the 2nd group and the control group. It was established an inverse correlation between serum concentration of the FGF19 and the BA excretion in the feces in all examined patients. It indicates a possible relationship between the low concentration of FGF19 in blood serum and malabsorption of the BA. Conclusion. Low level of FGF19 in the blood serum and a high excretion of BA in the feces may be one of the causes of BAD in patients undergoing cholecystectomy. Our results indicate the important role of FGF19 in the development of chronic diarrhea, which can be considered as one of the variants of postcholecystectomy syndrome.

scholarly journals Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids

2013 ◽  
Vol 304 (10) ◽  
pp. G940-G948 ◽  
Author(s):  
Justine H. Zhang ◽  
Jonathan D. Nolan ◽  
Sarah L. Kennie ◽  
Ian M. Johnston ◽  
Tracy Dew ◽  
...  
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Culture Fluid ◽  
Farnesoid X Receptor ◽  
Transcript Expression ◽  
Fibroblast Growth ◽  
Primary Explants ◽  
Fgf19 Expression ◽  
Fibroblast Growth Factor 19

Fibroblast growth factor 19 (FGF19) is proposed to be a negative feedback regulator of hepatic bile acid (BA) synthesis. We aimed to clarify the distribution of FGF19 expression in human intestine and to investigate induction in a novel explant system. Ileal and colonic mucosal biopsies were obtained at endoscopy and analyzed for FGF19 transcript expression. Primary explants were incubated with physiological concentrations of various BA for up to 6 h, and expression of FGF19 and other genes was determined. FGF19 transcripts were detected in ileum but were unquantifiable in colon. No loss of FGF19 mRNA occurred as a consequence of the explant system. Ileal FGF19 transcript expression was induced 350-fold by 50 μM chenodeoxycholate (CDCA, n = 24, P < 0.0001) and 161-fold by 50 μM glycochenodeoxycholate (GCDCA, n = 12, P = 0.0005). The responses of other genes to CDCA or GCDCA (50 μM) were smaller: median increases of ileal bile acid binding protein, organic solute transporter-α and -β, and short heterodimer partner were 2.4- to 4.0-fold; apical membrane sodium bile acid transporter and farnesoid X receptor (FXR) showed little change. The EC50 for FGF19 transcript induction by CDCA was 20 μM. FGF19 protein concentrations were significantly higher in the culture fluid from BA-stimulated explants. FGF19 induction with cholate was 81% of that found with CDCA, but deoxycholate (40%) and lithocholate (4%) were significantly less potent. The synthetic FXR agonist obeticholic acid was much more potent than CDCA with a 70-fold FGF19 stimulation at 1 μM. We concluded that FGF19 expression in human ileum is very highly responsive to BA. Changes in FGF19 induction are a potential mechanism involved in disorders of BA homeostasis.

M1725 Reduced Serum Fibroblast Growth Factor 19 (FGF19) in Patients with Idiopathic Bile Acid Malabsorption

2008 ◽  
Vol 134 (4) ◽  
pp. A-405-A-406 ◽  
Author(s):  
Ali M. Tasleem ◽  
Tracy Dew ◽  
Sara Balesaria ◽  
Gordon W. Brydon ◽  
Carel W. Le Roux ◽  
...  
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Bile Acid Malabsorption ◽  
Fibroblast Growth Factor 19

scholarly journals Developmental regulation of the intestinal FGF19 system in domestic pigs

2018 ◽  
Vol 314 (6) ◽  
pp. G647-G654 ◽  
Author(s):  
Aleix Gavaldà-Navarro ◽  
Jose J. Pastor ◽  
Alessandro Mereu ◽  
Francesc Villarroya ◽  
Ignacio R. Ipharraguerre
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Enteral Feeding ◽  
Developmental Regulation ◽  
Fibroblast Growth ◽  
Specific Manner ◽  
Endocrine Factor ◽  
Fibroblast Growth Factor 19 ◽  
Maximal Expression

Fibroblast growth factor-19 (FGF19) is an emerging endocrine factor involved in the regulation of bile acid homeostasis and energy metabolism in rodents and humans. In pigs, however, the FGF19 system remains largely unexplored. This study was designed to investigate the developmental regulation of the FGF19 system in domestic pigs. Samples of intestinal sections, liver, and plasma were collected from 24 pigs ( n = 6) at four developmental stages (birth, preweaning, postweaning, and adulthood). In the intestine, expression of the farnesoid X receptor (FXR) and FGF19 showed a congruent time- and region-dependent regulation, beginning soon after birth to achieve maximal expression in ileum during adulthood. The same temporal pattern was followed by the circulating concentration of FGF19, and these changes were accompanied by a time-related increase in the ileal proportion of bile acids that potently activate FXR. Conversely, genes belonging to the FGF19 signaling machinery achieved maximal expression in the small intestine at birth to decrease sharply afterward. In the liver, gene expression of FGF19 receptors and enzymes involved in bile acid biosynthesis paralleled after-birth changes in plasma concentration of this enterokine and attained a maximum during postweaning when plasma FGF19 was the lowest. Although detectable at birth, the hepatic expression of genes belonging to the bile acid-FXR-FGF19 pathway was low before the onset of enteral feeding. In summary, the porcine FGF19 system is present from birth, operative before the onset of enteral feeding, and regulated in a temporal and section-specific manner. NEW & NOTEWORTHY Fibroblast growth factor-19 (FGF19) is an emerging endocrine factor. The domestic pig is a translational model of value in biomedical research. We show for the first time that in pigs the intestinal FGF19 system is present from birth, operative before the onset of enteral feeding, and regulated in a temporal and section-specific manner. This work identifies pigs as a suitable model for investigating the implications of FGF19 signaling within and beyond the gut-liver axis.

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