Systematic review with meta‐analysis: neoplasia detection rate and post‐endoscopy Barrett's neoplasia in Barrett's oesophagus

2021 ◽  
Author(s):  
Nour Hamade ◽  
Amrit K. Kamboj ◽  
Rajesh Krishnamoorthi ◽  
Siddharth Singh ◽  
Leslie C. Hassett ◽  
...  
Keyword(s):  
Systematic Review ◽  
Detection Rate ◽  
Meta Analysis ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

Estimating neoplasia detection rate (NDR) in patients with Barrett’s oesophagus based on index endoscopy: a systematic review and meta-analysis

Gut ◽  
2019 ◽  
Vol 68 (12) ◽  
pp. 2122-2128 ◽  
Author(s):  
Sravanthi Parasa ◽  
Madhav Desai ◽  
Anusha Vittal ◽  
Viveksandeep T Chandrasekar ◽  
Asad Pervez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Detection Rate ◽  
Data Extraction ◽  
Meta Analysis ◽  
Quality Measure ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Cochrane Library ◽  
Barrett's Oesophagus ◽  
Pooled Prevalence

BackgroundBiopsies are obtained to confirm intestinal metaplasia and rule out prevalent dysplasia and cancer when Barrett’s oesophagus (BE) is detected at index upper endoscopy (oesophagogastroduodenoscopy [EGD]).AimThe purpose of this systematic review was to obtain summary estimates of the prevalence of high-grade dysplasia (HGD) and oesophageal adenocarcinoma (EAC) associated with BE during index EGD for chronic GERD symptoms, defined as neoplasia detection rate (NDR) which could be used as a quality measure.MethodsAn extensive search was performed within PUBMED, EMBASE and the Cochrane Library databases to identify studies in which patients underwent index endoscopy for the evaluation of the presence of BE. Two reviewers independently evaluated both the study eligibility and methodological quality and data extraction. A random-effects model (REM) based on the binomial distribution was used to calculate the pooled effects of the prevalence of BE-associated dysplasia and EAC.ResultsFor the calculation of dysplasia and EAC prevalence rates, a total of 11 studies with 10 632 patients met the inclusion criteria including 80.4% men with a mean age of 58.7 years and average BE length of 3.5 cm. The pooled prevalence of EAC, HGD and LGD was 3%(95% CI 2 to 5, 9 studies: 396/10 539 patients), 3%(95% CI 2 to 5 [REM], 9 studies: 388/10 539 patients) and 10%(95% CI 7 to 15 [REM], 10 studies: 907/8945 patients), respectively. For NDR, that is, the pooled prevalence of HGD/EAC was 7%(95% CI 4 to 10 [REM], 10 studies: 795/10 632 patients).ConclusionNDR is approximately 4% and could be used as a quality measure.

scholarly journals PTH-043 The accuracy of ultrathin endoscopy in the diagnosis of barrett’s oesophagus: systematic review and meta-analysis

2019 ◽  
Author(s):  
John McGoran ◽  
Jacobo Ortiz Fernández-Sordo ◽  
John SDe Caestecker ◽  
Rehan Haidry ◽  
Laurence B Lovat ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

scholarly journals Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis

Gut ◽  
2020 ◽  
pp. gutjnl-2020-321365 ◽  
Author(s):  
Leonardo Henry Eusebi ◽  
Giovanna Grazia Cirota ◽  
Rocco Maurizio Zagari ◽  
Alexander Charles Ford
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Barrett’S Oesophagus ◽  
Oesophageal Reflux ◽  
Oesophageal Adenocarcinoma ◽  
Low Grade ◽  
Barrett's Oesophagus ◽  
Global Prevalence ◽  
Pooled Prevalence ◽  
Geographical Regions

ObjectivesChronic gastro-oesophageal reflux might lead to the development of Barrett’s oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal reflux.DesignWe searched MEDLINE, Embase and Embase Classic to identify cross-sectional surveys that reported prevalence of BO or oesophageal adenocarcinoma in adults with gastro-oesophageal reflux. We extracted prevalence for all studies, both for endoscopically suspected and histologically confirmed cases. We calculated pooled prevalence according to study location, symptom frequency and sex, as well as ORs with 95% CIs.ResultsOf the 4963 citations evaluated, 44 reported prevalence of endoscopically suspected and/or histologically confirmed BO. Prevalence of BO among individuals with gastro-oesophageal reflux varied according to different geographical regions ranging from 3% to 14% for histologically confirmed BO with a pooled prevalence of 7.2% (95% CI 5.4% to 9.3%), whereas pooled prevalence for endoscopically suspected BO was 12.0% (95% CI 5.5% to 20.3%). There was heterogeneity in many of our analyses. Prevalence of BO was significantly higher in men, both for endoscopically suspected (OR=2.1; 95% CI 1.6 to 2.8) and histologically confirmed BO (OR=2.3; 95% CI 1.7 to 3.2). Dysplasia was present in 13.9% (95% CI 8.9% to 19.8%) of cases of histologically confirmed BO, 80.7% of which was low-grade.ConclusionThe prevalence of Barrett’s oesophagus among individuals with gastro-oesophageal reflux varied strikingly among countries, broadly resembling the geographical distribution of gastro-oesophageal reflux itself. Prevalence of BO was significantly higher in men.

scholarly journals Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis

Gut ◽  
2013 ◽  
Vol 63 (8) ◽  
pp. 1229-1237 ◽  
Author(s):  
Siddharth Singh ◽  
Sushil Kumar Garg ◽  
Preet Paul Singh ◽  
Prasad G Iyer ◽  
Hashem B El-Serag
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Barrett's Oesophagus

scholarly journals Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186305 ◽  
Author(s):  
Vincent T. Janmaat ◽  
Sophie H. van Olphen ◽  
Katharina E. Biermann ◽  
Leendert H. J. Looijenga ◽  
Marco B. Bruno ◽  
...  
Keyword(s):  
Systematic Review ◽  
Independent Predictor ◽  
Meta Analysis ◽  
Barrett’S Oesophagus ◽  
Neoplastic Progression ◽  
Barrett's Oesophagus

scholarly journals Wide-area transepithelial sampling in adjunct to forceps biopsy increases the absolute detection rates of Barrett’s oesophagus and oesophageal dysplasia: a meta-analysis and systematic review

2020 ◽  
Vol 7 (1) ◽  
pp. e000494
Author(s):  
Vishnu Charan Suresh Kumar ◽  
Prateek Harne ◽  
Venkata Suresh Patthipati ◽  
Abinash Subedi ◽  
Umair Masood ◽  
...  
Keyword(s):  
Systematic Review ◽  
Detection Rate ◽  
Meta Analysis ◽  
Relative Increase ◽  
Wide Area ◽  
Detection Rates ◽  
Absolute Increase ◽  
Forceps Biopsy ◽  
Barrett's Oesophagus ◽  
The Absolute

BackgroundWide-area transepithelial sampling (WATS) is a new technique that uses an abrasive brush to obtain samples from a larger surface area of the oesophagus. Studies have shown promising results that WATS in adjunct to forceps biopsy (FB) increases the detection rate of Barrett’s oesophagus (BE) as well as oesophageal dysplasia (ED). We conducted a systematic review and meta-analysis to compare the detection rates of BE and ED between FB and WATS in adjunct to FB.MethodsA Literature search was done using electronic databases, including PubMed, Embase, Scopus, Cochrane and CINAHL from inception to 26 April 2020. A meta-analysis comparing detection rates of WATS in adjunct to FB versus FB using the random-effects model was done using RevMan V.5.3.ResultsPooled data from 20 392 endoscopies across 11 studies showed an absolute increase in detection of 16% (95% CI 0.10% to 0.22%, p<0.00001). A relative increase of 1.62 was seen in detection rates of BE (95% CI 1.28 to 2.05, p<0.0001) when WATS was used with FB with the number needed to test (NNT) of 6.1 patients. For ED, a 2% absolute increase (95% CI 0.01 to 0.03, p=0.001) in additional diagnostic yield from WATS. A relative increase of 2.05 was seen in the detection rate of ED (95% CI 1.42 to 2.98, p=0.0001) yielding an NNT of 50 patients.ConclusionOur study shows that WATS, as an adjunct to FB, improves both the absolute detection rate and relative detection rate of both BE and ED as compared to FB alone.

scholarly journals Systematic review with meta-analysis: prevalence of prior and concurrent Barrett's oesophagus in oesophageal adenocarcinoma patients

2020 ◽  
Vol 52 (1) ◽  
pp. 20-36 ◽  
Author(s):  
Mimi C. Tan ◽  
Nabil Mansour ◽  
Donna L. White ◽  
Amy Sisson ◽  
Hashem B. El-Serag ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Barrett's Oesophagus
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