Prognostic evaluation of perinephric fat, renal sinus fat, and renal vein invasion for patients with pathological stage T3a clear-cell renal cell carcinoma

2018 ◽  
Vol 123 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Paras H. Shah ◽  
Timothy D. Lyon ◽  
Christine M. Lohse ◽  
John C. Cheville ◽  
Bradley C. Leibovich ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Cell ◽  
Renal Vein ◽  
Clear Cell ◽  
Pathological Stage ◽  
Cell Renal Cell Carcinoma ◽  
Renal Sinus ◽  
Prognostic Evaluation ◽  
Renal Sinus Fat ◽  
Perinephric Fat

Renal Sinus Fat Invasion in pT3a Clear Cell Renal Cell Carcinoma Affects Outcomes of Patients Without Nodal Involvement or Distant Metastases

2009 ◽  
Vol 181 (5) ◽  
pp. 2027-2032 ◽  
Author(s):  
Roberto Bertini ◽  
Marco Roscigno ◽  
Massimo Freschi ◽  
Elena Strada ◽  
Giovanni Petralia ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Distant Metastases ◽  
Nodal Involvement ◽  
Cell Renal Cell Carcinoma ◽  
Renal Sinus ◽  
Renal Sinus Fat

Juxtatumoral perinephric fat analysis in clear cell renal cell carcinoma

2018 ◽  
Vol 44 (4) ◽  
pp. 1470-1480 ◽  
Author(s):  
Tania S. Gill ◽  
Bino A. Varghese ◽  
Darryl H. Hwang ◽  
Steven Y. Cen ◽  
Manju Aron ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Perinephric Fat

Intratumoural heterogeneity may hinder precision medicine strategies in patients with clear cell renal cell carcinoma

2018 ◽  
Vol 71 (5) ◽  
pp. 467-471 ◽  
Author(s):  
Maria Rosaria Raspollini ◽  
Ilaria Montagnani ◽  
Rodolfo Montironi ◽  
Francesca Castiglione ◽  
Guido Martignoni ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Precision Medicine ◽  
Renal Cell ◽  
Clear Cell ◽  
Molecular Heterogeneity ◽  
Precision Oncology ◽  
Cell Renal Cell Carcinoma ◽  
Renal Sinus ◽  
The Moment

Clear cell renal cell carcinoma (ccRCC) is an heterogeneous tumour at architectural, cellular and molecular level, a reason why the 2014 International Society of Urological Pathology consensus recommended wide sampling of RCC masses to include at least 1 block/cm of tumour together with perpendicular sections of the tumour/perinephric fat interface and the tumour/renal sinus interface. Intratumoural molecular heterogeneity may be a limitation at the moment of defining precision medicine strategies based on gene mutation status. This study analyses the presence of any mutation of KRAS, NRAS, BRAF, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET and EGFR genes in 20 tissue blocks from a case of ccRCC and its metastasis. We observed the presence of the mutation at pH1047R of PIK3CA gene in five samples of the tumour, while the remaining 15 samples did not show any mutation at PIK3CA or any other investigated gene. There is a great need to develop novel RCC sampling strategies to overcome tumour heterogeneity prior to define precision oncology strategies.

Clear cell renal cell carcinoma bone metastasis: What should be considered in prognostic evaluation

2019 ◽  
Vol 45 (7) ◽  
pp. 1246-1252 ◽  
Author(s):  
Zixiong Huang ◽  
Yiqing Du ◽  
Xiaopeng Zhang ◽  
Huixin Liu ◽  
Shijun Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Bone Metastasis ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Prognostic Evaluation

scholarly journals The Difference in Prognosis between Renal Sinus Fat and Perinephric Fat Invasion for pT3a Renal Cell Carcinoma: A Meta-Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149420 ◽  
Author(s):  
Zhiling Zhang ◽  
Chunping Yu ◽  
Liliya Velet ◽  
Yonghong Li ◽  
Lijuan Jiang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Meta Analysis ◽  
Renal Sinus ◽  
The Difference ◽  
Renal Sinus Fat ◽  
Perinephric Fat

IS RENAL SINUS FAT INVASION THE SAME AS PERINEPHRIC FAT INVASION FOR pT3a RENAL CELL CARCINOMA?

2005 ◽  
Vol 174 (4 Part 1) ◽  
pp. 1218-1221 ◽  
Author(s):  
R. HOUSTON THOMPSON ◽  
BRADLEY C. LEIBOVICH ◽  
JOHN C. CHEVILLE ◽  
W. SCOTT WEBSTER ◽  
CHRISTINE M. LOHSE ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Sinus ◽  
Renal Sinus Fat ◽  
Perinephric Fat

scholarly journals Contact with renal sinus is associated with poor prognosis in surgically treated pT1 clear cell renal cell carcinoma

2020 ◽  
Vol 27 (8) ◽  
pp. 657-662 ◽  
Author(s):  
Keita Izumi ◽  
Kazutaka Saito ◽  
Takayuki Nakayama ◽  
Shohei Fukuda ◽  
Hiroshi Fukushima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Renal Sinus
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