scholarly journals Methionine down-regulates TLR4/MyD88/NF-κB signalling in osteoclast precursors to reduce bone loss during osteoporosis

2013 ◽  
Vol 171 (1) ◽  
pp. 107-121 ◽  
Author(s):  
V Vijayan ◽  
M Khandelwal ◽  
K Manglani ◽  
S Gupta ◽  
A Surolia
Keyword(s):  
Bone Loss ◽  
Osteoclast Precursors ◽  
Reduce Bone Loss

Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat

1998 ◽  
Vol 274 (2) ◽  
pp. E328-E335 ◽  
Author(s):  
C. K. Lea ◽  
A. M. Flanagan
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Protective Effect ◽  
Cancellous Bone ◽  
Plasma Levels ◽  
Slow Release ◽  
Bone Volume ◽  
Ovariectomized Rat ◽  
Ovx Rats ◽  
Reduce Bone Loss

The effect of androstenedione (ADIONE) slow-release pellets on cancellous bone volume (BV/TV) at the tibial metaphysis was investigated in ovariectomized (OVX) rats at various times from 21 to 180 days. Plasma levels of ADIONE and testosterone (T) in OVX rats were significantly reduced at 21 days and were restored close to levels in the sham rats with the 1.5-mg ADIONE pellet. OVX animals with and without ADIONE pellets resulted in close to a 50% reduction in BV/TV by day 21. By day 180, OVX rats had only ∼5% BV/TV, whereas that in ADIONE-treated OVX rats was significantly greater at ∼12%. The reduced BV/TV was associated with increased bone resorption and formation. In a separate 90-day experiment, we found that the antiandrogen, Casodex, abrogated the ADIONE-induced skeletal-protective effect in OVX rats, whereas the antiaromatase, Arimidex, had no effect. This provides evidence that ADIONE protects against the development of osteopenia in the estrogen-deficient rat and mediates its effect through androgens and not estrogens.

scholarly journals IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis

2014 ◽  
Vol 74 (6) ◽  
pp. 1284-1292 ◽  
Author(s):  
Iannis E Adamopoulos ◽  
Erika Suzuki ◽  
Cheng-Chi Chao ◽  
Dan Gorman ◽  
Sarvesh Adda ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Gene Transfer ◽  
Bone Resorption ◽  
Bone Loss ◽  
Bone Destruction ◽  
Chronic Inflammatory Disease ◽  
Epidermal Hyperplasia ◽  
Osteoclast Precursors

BackgroundPsoriatic arthritis (PsA) is a chronic inflammatory disease characterised by clinical features that include bone loss and epidermal hyperplasia. Aberrant cytokine expression has been linked to joint and skin pathology; however, it is unclear which cytokines are critical for disease initiation. Interleukin 17A (IL-17A) participates in many pathological immune responses; however, its role in PsA has not been fully elucidated.ObjectiveTo determine the role of IL-17A in epidermal hyperplasia and bone destruction associated with psoriatic arthritis.DesignAn in vivo gene transfer approach was used to investigate the role of IL-17A in animal models of inflammatory (collagen-induced arthritis) and non-inflammatory (receptor activator of NF-κB ligand (RANKL)-gene transfer) bone loss.ResultsIL-17A gene transfer induced the expansion of IL-17RA+CD11b+Gr1low osteoclast precursors and a concomitant elevation of biomarkers indicative of bone resorption. This occurred at a time preceding noticeable joint inflammation, suggesting that IL-17A is critical for the induction of pathological bone resorption through direct activation of osteoclast precursors. Moreover, IL-17A induced a second myeloid population CD11b+Gr1high neutrophil-like cells, which was associated with cutaneous pathology including epidermal hyperplasia, parakeratosis and Munro's microabscesses formation.ConclusionsCollectively, these data support that IL-17A can play a key role in the pathogenesis of inflammation-associated arthritis and/or skin disease, as observed in PsA.

Do Progestogens and Progesterone Reduce Bone Loss?

1996 ◽  
Vol 3 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Nicholas Panay ◽  
John Studd
Keyword(s):  
Bone Loss ◽  
Reduce Bone Loss

Strategy of Aggressive Steroid Weaning and Routine Alendronate Therapy to Reduce Bone Loss After Cardiac Transplantation

2007 ◽  
Vol 39 (10) ◽  
pp. 3340-3343 ◽  
Author(s):  
G. Yong ◽  
H. Hayes ◽  
G. O’Driscoll
Keyword(s):  
Bone Loss ◽  
Cardiac Transplantation ◽  
Reduce Bone Loss

scholarly journals Phytoestrogens Reduce Bone Loss and Bone Resorption in Oophorectomized Rats

1997 ◽  
Vol 127 (9) ◽  
pp. 1795-1799 ◽  
Author(s):  
Christine R. Draper ◽  
Michael J. Edel ◽  
Ian M. Dick ◽  
Andrew G. Randall ◽  
Graeme B. Martin ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Reduce Bone Loss

The Cooperative Role of CCR1 and CCR5 in the Migration of Osteoclast Precursors and RANKL+ Cells Throughout Inflammatory Bone Loss after Periodontal Infection

2010 ◽  
Vol 135 ◽  
pp. S141
Author(s):  
Carlos Repeke ◽  
Samuel Fereira Jr ◽  
Ana Paula Trombone ◽  
Priscila Colavite ◽  
Francine Raimundo ◽  
...  
Keyword(s):  
Bone Loss ◽  
Osteoclast Precursors ◽  
Periodontal Infection
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