Crucial role of the orexin-B C-terminus in the induction of OX1receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis

Pascal Nicole; Pierre Couvineau; Nadege Jamin; Thierry Voisin; Alain Couvineau

doi:10.1111/bph.13287

Crucial role of the orexin-B C-terminus in the induction of OX1receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis

British Journal of Pharmacology ◽

10.1111/bph.13287 ◽

2015 ◽

Vol 172 (21) ◽

pp. 5211-5223 ◽

Cited By ~ 6

Author(s):

Pascal Nicole ◽

Pierre Couvineau ◽

Nadege Jamin ◽

Thierry Voisin ◽

Alain Couvineau

Keyword(s):

Molecular Modelling ◽

Crucial Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Alanine Scanning ◽

C Terminus

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The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ◽

10.1016/s0167-4838(97)00095-2 ◽

1997 ◽

Vol 1342 (1) ◽

pp. 90-102 ◽

Cited By ~ 5

Author(s):

Joseph A Rafferty ◽

Jane E.A Wibley ◽

Peter Speers ◽

Ian Hickson ◽

Geoffrey P Margison ◽

...

Keyword(s):

Molecular Modelling ◽

Potential Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Dna Alkyltransferase

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Site-directed mutagenesis reveals a conservation of the copper-binding site and the crucial role of His24 in CopH from Cupriavidus metallidurans CH34

Journal of Inorganic Biochemistry ◽

10.1016/j.jinorgbio.2009.09.022 ◽

2009 ◽

Vol 103 (12) ◽

pp. 1721-1728 ◽

Cited By ~ 7

Author(s):

Véronique Sendra ◽

Serge Gambarelli ◽

Beate Bersch ◽

Jacques Covès

Keyword(s):

Binding Site ◽

Crucial Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Copper Binding ◽

Cupriavidus Metallidurans Ch34 ◽

Cupriavidus Metallidurans

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Functional characterization of an anti-estradiol antibody by site-directed mutagenesis and molecular modelling: modulation of binding properties and prominent role of the VLdomain in estradiol recognition

Journal of Molecular Recognition ◽

10.1002/jmr.553 ◽

2002 ◽

Vol 15 (1) ◽

pp. 6-18 ◽

Cited By ~ 7

Author(s):

Stéphane Coulon ◽

Jean-Luc Pellequer ◽

Thierry Blachère ◽

Martine Chartier ◽

Elisabeth Mappus ◽

...

Keyword(s):

Molecular Modelling ◽

Functional Characterization ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Binding Properties

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Site-directed mutagenesis and molecular modelling studies show the role of Asp82 and cysteines in rat acylase 1, a member of the M20 family

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2005.03.019 ◽

2005 ◽

Vol 330 (2) ◽

pp. 540-546

Author(s):

Sameh Herga ◽

Alexandre Brutus ◽

Rosa Maria Vitale ◽

Hélène Miche ◽

Josette Perrier ◽

...

Keyword(s):

Molecular Modelling ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Molecular Modelling Studies ◽

Modelling Studies

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Crucial Role of Asp408 in the Proton Translocation Pathway of Multidrug Transporter AcrB: Evidence from Site-Directed Mutagenesis and Carbodiimide Labeling

Biochemistry ◽

10.1021/bi900446j ◽

2009 ◽

Vol 48 (25) ◽

pp. 5801-5812 ◽

Cited By ~ 49

Author(s):

Markus A. Seeger ◽

Christoph von Ballmoos ◽

François Verrey ◽

Klaas M. Pos

Keyword(s):

Crucial Role ◽

Proton Translocation ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Multidrug Transporter ◽

Translocation Pathway

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Cys Site-Directed Mutagenesis of the Human SLC1A5 (ASCT2) Transporter: Structure/Function Relationships and Crucial Role of Cys467 for Redox Sensing and Glutamine Transport

International Journal of Molecular Sciences ◽

10.3390/ijms19030648 ◽

2018 ◽

Vol 19 (3) ◽

pp. 648 ◽

Cited By ~ 9

Author(s):

Mariafrancesca Scalise ◽

Lorena Pochini ◽

Lara Console ◽

Gilda Pappacoda ◽

Piero Pingitore ◽

...

Keyword(s):

Structure Function ◽

Crucial Role ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Glutamine Transport ◽

Redox Sensing ◽

Transporter Structure

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Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

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The role of cysteine 206 in allosteric inhibition of Escherichia coli citrate synthase. Studies by chemical modification, site-directed mutagenesis, and 19F NMR.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54766-9 ◽

1991 ◽

Vol 266 (31) ◽

pp. 20709-20713

Author(s):

L.J. Donald ◽

B.R. Crane ◽

D.H. Anderson ◽

H.W. Duckworth

Keyword(s):

Escherichia Coli ◽

Chemical Modification ◽

Citrate Synthase ◽

Site Directed Mutagenesis ◽

19F Nmr ◽

Directed Mutagenesis ◽

Allosteric Inhibition

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Role of Cysteine Residues in the N-Terminal Extracellular Domain of the Human VIP 1 Receptor for Ligand Binding A Site-directed Mutagenesis Studya

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1996.tb17524.x ◽

2006 ◽

Vol 805 (1) ◽

pp. 585-589 ◽

Cited By ~ 4

Author(s):

PASCALE GAUDIN ◽

ALAIN COUVINEAU ◽

JEAN-JOSÉ MAORET ◽

CHRISTIANE ROUYER-FESSARD ◽

MARC LABURTHE

Keyword(s):

Ligand Binding ◽

Extracellular Domain ◽

Site Directed Mutagenesis ◽

Cysteine Residues ◽

Directed Mutagenesis ◽

A Site

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Site-directed mutagenesis of tyrosine hydroxylase. Role of serine 40 in catalysis.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)35673-4 ◽

1992 ◽

Vol 267 (36) ◽

pp. 25754-25758

Author(s):

J Wu ◽

D Filer ◽

A.J. Friedhoff ◽

M Goldstein

Keyword(s):

Tyrosine Hydroxylase ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis

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