scholarly journals Trimetazidine does not alter metabolic substrate oxidation in cardiac mitochondria of target patient population

2016 ◽  
Vol 173 (9) ◽  
pp. 1529-1540 ◽  
Author(s):  
M Cavar ◽  
M Ljubkovic ◽  
C Bulat ◽  
D Bakovic ◽  
D Fabijanic ◽  
...  
Keyword(s):  
Patient Population ◽  
Substrate Oxidation ◽  
Cardiac Mitochondria ◽  
Metabolic Substrate ◽  
Target Patient Population

scholarly journals PMD28 USING A WEB-PANEL TO AID DEFINITION OF A TARGET PATIENT POPULATION TO ASSIST RISK MANAGEMENT

2004 ◽  
Vol 7 (3) ◽  
pp. 309
Author(s):  
SC Eaton ◽  
SF Cook ◽  
EB Andrews ◽  
KA Hollis ◽  
VZ Ameen ◽  
...  
Keyword(s):  
Risk Management ◽  
Patient Population ◽  
Target Patient Population ◽  
Definition Of

scholarly journals First-in-human trial design for W0101: A first-in-class antibody-drug conjugate targeting IGF-1R and identification of the target patient population

2018 ◽  
Vol 29 ◽  
pp. viii145-viii146
Author(s):  
C.A. Gomez-Roca ◽  
E. Garralda-Cabanas ◽  
F. Cruzalegui ◽  
F. Ausseil ◽  
G. Zorza ◽  
...  
Keyword(s):  
Patient Population ◽  
Trial Design ◽  
Antibody Drug Conjugate ◽  
Human Trial ◽  
Drug Conjugate ◽  
Target Patient Population ◽  
Class Antibody ◽  
Antibody Drug

Patient involvement in relative effectiveness assessments in the European Network for Health Technology Assessment

2021 ◽  
Vol 37 ◽  
Author(s):  
Ida Kristin Ørjasæter Elvsaas ◽  
Sabine Ettinger ◽  
Anne Willemsen
Keyword(s):  
Health Technology Assessment ◽  
Technology Assessment ◽  
Patient Population ◽  
Patient Involvement ◽  
Relative Effectiveness ◽  
Health Technology ◽  
European Network ◽  
Target Patient Population

Abstract Patient involvement in the process of producing health technology assessments has become increasingly important. In the European Network for Health Technology Assessment (EUnetHTA), several approaches to patient involvement were explored. The outcome was a document on “Patient Input in Relative Effectiveness Assessments” that is available for access and was published in 2019. The aim of this article is to analyze the experience gained by EUnetHTA in patient involvement for EUnetHTA assessment production, describe and quantify the approaches used, and outline the challenges and avenues for the improvement of current processes. Patients were involved in twenty-three of thirty-six pharmaceutical and other technology EUnetHTA assessments from June 2016 until the end of November 2019. Approaches to patient involvement included using a patient input template, one-on-one conversations, group conversations, scoping meeting with patients, and other approaches. Although it is recognized that patient involvement is important to understand the needs of the target patient population, challenges remain with timely patient involvement. Additionally, further efforts are needed to guide assessment teams on how to implement and enhance the visibility of patient input in assessments.

scholarly journals A cell culture platform for quantifying metabolic substrate oxidation in bicarbonate-buffered medium

2021 ◽  
pp. 101547
Author(s):  
James R. Krycer ◽  
Mary Lor ◽  
Rebecca L. Fitzsimmons ◽  
James E. Hudson
Keyword(s):  
Cell Culture ◽  
Substrate Oxidation ◽  
Metabolic Substrate ◽  
A Cell

Redox regulation of endogenous substrate oxidation by cardiac mitochondria

2006 ◽  
Vol 291 (3) ◽  
pp. H1436-H1445 ◽  
Author(s):  
Paavo Korge ◽  
James N. Weiss
Keyword(s):  
Fatty Acids ◽  
Redox Regulation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Substrate Oxidation ◽  
Cardiac Mitochondria ◽  
The Matrix ◽  
Endogenous Substrate ◽  
Exogenous Substrates

Reactive oxygen species (ROS) play important roles in regulating mitochondrial function, as well as in ischemia-reperfusion injury and cardioprotection. Here we show that, in the absence of exogenous substrates, cardiac mitochondria have a surprisingly large capacity to phosphorylate ADP by oxidizing endogenous substrates, provided that H2O2 is removed from the extramitochondrial environment and a reduced environment is maintained in the matrix. In isolated mitochondria without exogenous substrates, addition of catalase and the membrane-permeant reducing agent N-acetylcysteine (Nac) or the ROS scavenger mercaptopropionyl glycine significantly increased the ability to phosphorylate added ADP, as demonstrated by 1) full recovery of membrane potential (Δψ) and matrix volume from ADP-induced dissipation and shrinkage, 2) ADP-dependent increase in O2 consumption, and 3) enhanced rate of ATP synthesis. Removal of extramitochondrial H2O2 by catalase was required to stimulate endogenous substrate oxidation, as shown by the increase in O2 consumption and Δψ. This effect was greatly enhanced by addition of Nac or mercaptopropionyl glycine to suppress oxidation-induced ROS increases in the matrix. Theoretical considerations, as well as reversible inhibition of O2 consumption with 3-mercaptopropionic acid and pyruvate in state 3, indicate that these substrates are fatty acids. Under in vivo conditions in which powerful antioxidant conditions are maintained, this mechanism may be important in stimulation of β-oxidation and ATP production at low levels of extramitochondrial fatty acids. Incapacitation of this mechanism may potentially contribute to mitochondrial dysfunction during oxidative stress.

A sequential enriched design for target patient population in psychiatric clinical trials

2014 ◽  
Vol 33 (17) ◽  
pp. 2953-2967 ◽  
Author(s):  
Yeh-Fong Chen ◽  
Xiangmin Zhang ◽  
Roy N. Tamura ◽  
Chiung M. Chen
Keyword(s):  
Clinical Trials ◽  
Patient Population ◽  
Target Patient Population

Ambient temperature influences metabolic substrate oxidation curves during running and cycling in healthy men

2019 ◽  
Vol 20 (1) ◽  
pp. 90-99 ◽  
Author(s):  
Dominique D. Gagnon ◽  
Lina Perrier ◽  
Sandra C. Dorman ◽  
Bruce Oddson ◽  
Céline Larivière ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Substrate Oxidation ◽  
Healthy Men ◽  
Metabolic Substrate

Arrangement of Mitochondria in Spermatozoa of the Mexican Axolotl, Ambystoma Mexicanum

1973 ◽  
Vol 31 ◽  
pp. 626-627
Author(s):  
Ezzatollah Keyhani ◽  
Larry F. Lemanski ◽  
Sharon L. Lemanski
Keyword(s):  
Plasma Membrane ◽  
Sperm Motility ◽  
Substrate Oxidation ◽  
Ambystoma Mexicanum ◽  
Axial Filament ◽  
Mexican Axolotl ◽  
Middle Piece

Energy for sperm motility is provided by both glycolytic and respiratory pathways. Mitochondria are involved in the latter pathway and conserve energy of substrate oxidation by coupling to phosphorylation. During spermatogenesis, the mitochondria undergo extensive transformation which in many species leads to the formation of a nebemkem. The nebemkem subsequently forms into a helix around the axial filament complex in the middle piece of spermatozoa.Immature spermatozoa of axolotls contain numerous small spherical mitochondria which are randomly distributed throughout the cytoplasm (Fig. 1). As maturation progresses, the mitochondria appear to migrate to the middle piece region where they become tightly packed to form a crystalline-like sheath. The cytoplasm in this region is no longer abundant (Fig. 2) and the plasma membrane is now closely apposed to the outside of the mitochondrial layer.

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