scholarly journals Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

2018 ◽  
Vol 175 (12) ◽  
pp. 2204-2218 ◽  
Author(s):  
Jia Yu Peppermint Lee ◽  
Natalie J Saez ◽  
Ben Cristofori-Armstrong ◽  
Raveendra Anangi ◽  
Glenn F King ◽  
...  
Keyword(s):  
Ion Channels ◽  
Rat Model ◽  
Inflammatory Pain ◽  
Acid Sensing Ion Channels

Acid-sensing ion channels

2006 ◽  
pp. S100-S101
Author(s):  
S P H Alexander ◽  
A Mathie ◽  
J A Peters
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid Sensing Ion Channels (ASICs) und 5-HT-Rezeptoren bei GERD. Untersuchungen zur Genexpression im pharmakologischen Modell

2015 ◽  
Vol 53 (08) ◽  
Author(s):  
A Shcherbokova ◽  
H Abdel-Aziz ◽  
O Kelber ◽  
K Nieber ◽  
G Ulrich-Merzenich
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid-Sensing Ion Channels

2020 ◽  
Author(s):  
Stefan Gründer
Keyword(s):  
Nervous System ◽  
Ion Channels ◽  
Excitatory Synapses ◽  
Detailed Characterization ◽  
High Affinity ◽  
Acid Sensing Ion Channels ◽  
Long Time ◽  
Pathological Pain

Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. Being almost ubiquitously present in neurons of the vertebrate nervous system, their precise function remained obscure for a long time. Various animal toxins that bind to ASICs with high affinity and specificity have been tremendously helpful in uncovering the role of ASICs. We now know that they contribute to synaptic transmission at excitatory synapses as well as to sensing metabolic acidosis and nociception. Moreover, detailed characterization of mouse models uncovered an unanticipated role of ASICs in disorders of the nervous system like stroke, multiple sclerosis, and pathological pain. This review provides an overview on the expression, structure, and pharmacology of ASICs plus a summary of what is known and what is still unknown about their physiological functions and their roles in diseases.

Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain

2021 ◽  
Vol 899 ◽  
pp. 174029
Author(s):  
Sang Wan Ryu ◽  
Yeo Ok Kim ◽  
Han-Byul Kim ◽  
Seog Bae Oh ◽  
Jeong Il Choi ◽  
...  
Keyword(s):  
Rat Model ◽  
Inflammatory Pain ◽  
Antinociceptive Effect
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