Potential role of acid sensing ion channels and 5-hydroxytryptamine receptors in a rat model of gastro-esophageal reflux disease

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
A Shcherbokova ◽  
H Abdel Aziz ◽  
O Kelber ◽  
G Ulrich-Merzenich
Keyword(s):  
Ion Channels ◽  
Rat Model ◽  
Reflux Disease ◽  
Potential Role ◽  
Esophageal Reflux ◽  
Hydroxytryptamine Receptors ◽  
Acid Sensing Ion Channels

Sa1719 Potential Role of Acid Sensitive Ion Channels and 5-Hydroxytryptamine Receptors in a Rat Model of Refux Esophagitis

2016 ◽  
Vol 150 (4) ◽  
pp. S356
Author(s):  
Anastasia Shcherbakova ◽  
Heba Abdel-Aziz ◽  
Olaf Kelber ◽  
Gudrun Ulrich-Merzenich
Keyword(s):  
Ion Channels ◽  
Rat Model ◽  
Potential Role ◽  
Hydroxytryptamine Receptors

Acid-Sensing Ion Channels

2020 ◽  
Author(s):  
Stefan Gründer
Keyword(s):  
Nervous System ◽  
Ion Channels ◽  
Excitatory Synapses ◽  
Detailed Characterization ◽  
High Affinity ◽  
Acid Sensing Ion Channels ◽  
Long Time ◽  
Pathological Pain

Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. Being almost ubiquitously present in neurons of the vertebrate nervous system, their precise function remained obscure for a long time. Various animal toxins that bind to ASICs with high affinity and specificity have been tremendously helpful in uncovering the role of ASICs. We now know that they contribute to synaptic transmission at excitatory synapses as well as to sensing metabolic acidosis and nociception. Moreover, detailed characterization of mouse models uncovered an unanticipated role of ASICs in disorders of the nervous system like stroke, multiple sclerosis, and pathological pain. This review provides an overview on the expression, structure, and pharmacology of ASICs plus a summary of what is known and what is still unknown about their physiological functions and their roles in diseases.

scholarly journals Acid-sensing ion channels in sensory signaling

2020 ◽  
Vol 318 (3) ◽  
pp. F531-F543 ◽  
Author(s):  
Marcelo D. Carattino ◽  
Nicolas Montalbetti
Keyword(s):  
Nervous System ◽  
Ion Channels ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Genetically Modified ◽  
Physiological Processes ◽  
Acid Sensing Ion Channels ◽  
Genetically Modified Mice ◽  
Sensory Processes

Acid-sensing ion channels (ASICs) are cation-permeable channels that in the periphery are primarily expressed in sensory neurons that innervate tissues and organs. Soon after the cloning of the ASIC subunits, almost 20 yr ago, investigators began to use genetically modified mice to assess the role of these channels in physiological processes. These studies provide critical insights about the participation of ASICs in sensory processes, including mechanotransduction, chemoreception, and nociception. Here, we provide an extensive assessment of these findings and discuss the current gaps in knowledge with regard to the functions of ASICs in the peripheral nervous system.

PA.10 ROLE OF VIRTUAL CHROMO-ENDOSCOPY (CVC) FOR DETECTION OF PATIENTS WITH COMPLICATED GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD): APILOTSTUDY

2008 ◽  
Vol 40 ◽  
pp. S79
Author(s):  
P. Fedeli ◽  
I.A. Cazzato ◽  
P. Cesaro ◽  
G. Vitale ◽  
G. Ianiro ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Esophageal Reflux

Diabetes-induced impairment of macrophage cytokine release in a rat model: Potential role of serum lipids

Life Sciences ◽  
1998 ◽  
Vol 63 (13) ◽  
pp. 1127-1136 ◽  
Author(s):  
Deborah L. Doxey ◽  
Salvador Nares ◽  
Bina Park ◽  
Chi Trieu ◽  
Christopher W. Cutler ◽  
...  
Keyword(s):  
Rat Model ◽  
Serum Lipids ◽  
Potential Role ◽  
Model Potential ◽  
Cytokine Release ◽  
Macrophage Cytokine

scholarly journals Role of Immediate Release and Delayed Release Omeprazole in Patients with Gastro Esophageal Reflux Disease

2017 ◽  
Vol 11 (2) ◽  
pp. 67-73
Author(s):  
Mahabub Rahman ◽  
Dewan Saifuddin Ahmed ◽  
Syeda Nur E Jannat ◽  
MM Shahin Ul Islam ◽  
Abu Ahmed Abdullah
Keyword(s):  
Reflux Disease ◽  
Immediate Release ◽  
Esophageal Reflux ◽  
Double Blind ◽  
Delayed Release ◽  
End Of Treatment ◽  
Significant Difference ◽  
Group A ◽  
Group B

Proton pump inhibitors are widely used for Gastro Esophageal Reflux Disease (GERD) treatment. This prospective double blind randomized cross over study was carried out in the Department of Gastroenterology, BSMMU from June 2007 to May 2008 to assess the efficacy of Immediate-release omeprazole (IR-OMEP) & Delayed-release Omeprazole (DR-OMEP) in relieving symptoms & healing of oesophagitis in GERD. All patients who fulfilled the inclusion criteria underwent upper gastrointestinal (UGI) endoscopy to be lebelled as nonerosive and erosive GERD. Among total 69 patients, 43 (62.3 %) had nonerosive and 26 (37.7 %) had erosive GERD. Patients were divided into group A (35) and group B (34) who received group A drugs (20 mg IR-OMEP bd) and group B drugs (20 mg DROMEP bd) from day 1-14 respectively. Then drugs were crossed over (group A: 20mg DR-OMEP bd; group B: 20 mg IR-OMEP bd) from day 15-28. Improvement of heartburn, regurgitation in each group were assessed in every week, during drug cross over and at the end and then compared between two groups. There was no significant difference in relieving heartburn and regurgitation between IR-OMEP and DR-OMEP either in erosive or nonerosive GERD (P>0.50). Patients with erosive GERD underwent UGI endoscopy at the end of treatment to see healing of esophagitis. Study showed significant healing of oesophagitis in group A after 4 weeks than group B (14%) (P<0.05) but there is no superiority of IR-OMEP over DR-OMEP in relieving symptoms of GERD.Faridpur Med. Coll. J. Jul 2016;11(2): 67-73

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