scholarly journals A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR

2021 ◽  
Author(s):  
Jia Liu ◽  
Allison P. Berg ◽  
Yiting Wang ◽  
Walailak Jantarajit ◽  
Katy J. Sutcliffe ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Small Molecule ◽  
Channel Gating

scholarly journals Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia

Nature ◽  
2019 ◽  
Vol 567 (7748) ◽  
pp. 405-408 ◽  
Author(s):  
Katrina A. Muraglia ◽  
Rajeev S. Chorghade ◽  
Bo Ram Kim ◽  
Xiao Xiao Tang ◽  
Viral S. Shah ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Ion Channels ◽  
Small Molecule ◽  
Airway Epithelia ◽  
Cystic Fibrosis Airway

scholarly journals Conformational Changes in a Pore-lining Helix Coupled to Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating

2007 ◽  
Vol 283 (8) ◽  
pp. 4957-4966 ◽  
Author(s):  
Edward J. Beck ◽  
Yu Yang ◽  
Sirin Yaemsiri ◽  
Viswanathan Raghuram
Keyword(s):  
Cystic Fibrosis ◽  
Conformational Changes ◽  
Channel Gating ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Cystic Fibrosis Transmembrane ◽  
Pore Lining

New anti-pseudomonal agents for cystic fibrosis- still needed in the era of small molecule CFTR modulators?

2018 ◽  
Vol 19 (12) ◽  
pp. 1327-1336 ◽  
Author(s):  
Jane C. Davies ◽  
Isaac Martin
Keyword(s):  
Cystic Fibrosis ◽  
Small Molecule ◽  
Cftr Modulators

scholarly journals Small molecule‐facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis

2019 ◽  
Vol 176 (11) ◽  
pp. 1764-1779 ◽  
Author(s):  
Michele Fiore ◽  
Claudia Cossu ◽  
Valeria Capurro ◽  
Cristiana Picco ◽  
Alessandra Ludovico ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Small Molecule ◽  
Therapeutic Approach ◽  
Anion Transporters ◽  
Novel Therapeutic ◽  
In Cells

Intracellular Cysteines of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulate Channel Gating

2002 ◽  
Vol 12 (1) ◽  
pp. 1-008 ◽  
Author(s):  
Christian Ketchum ◽  
Hongwen Yue ◽  
Karen Alessi ◽  
Shreenivas Devidas ◽  
William Guggino ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Channel Gating ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Cystic Fibrosis Transmembrane

S138 Inhibition of auto-inflammation in cystic fibrosis using small molecule therapy

2018 ◽  
Author(s):  
H Jarosz-Griffiths ◽  
T Scambler ◽  
J Holbrook ◽  
S Lara Reyna ◽  
C Wong ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Small Molecule
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