Discovery of novel 5-methyl-1H -pyrazole derivatives as potential antiprostate cancer agents: Design, synthesis, molecular modeling, and biological evaluation

Chemical Biology & Drug Design ◽

10.1111/cbdd.13173 ◽

2018 ◽

Vol 91 (6) ◽

pp. 1113-1124 ◽

Author(s):

Daoguang Zhang ◽

Solomon Asnake ◽

Jingya Zhang ◽

Per-Erik Olsson ◽

Guisen Zhao

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Pyrazole Derivatives ◽

Design Synthesis

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Design, synthesis and biological evaluation of novel 1,3,4-trisubstituted pyrazole derivatives as potential chemotherapeutic agents for hepatocellular carcinoma

Bioorganic Chemistry ◽

10.1016/j.bioorg.2018.03.014 ◽

2018 ◽

Vol 78 ◽

pp. 149-157 ◽

Author(s):

Marwa F. Harras ◽

Rehab Sabour

Keyword(s):

Hepatocellular Carcinoma ◽

Biological Evaluation ◽

Chemotherapeutic Agents ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Novel 4,5-dihydro-1H-pyrazole derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity and molecular modeling

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.131537 ◽

2021 ◽

pp. 131537

Author(s):

Tingting Zhang ◽

Hui Liu ◽

Tong Lu ◽

Guilan Zhang ◽

Tingting Xiao ◽

...

Keyword(s):

Crystal Structure ◽

Biological Activity ◽

Molecular Modeling ◽

Succinate Dehydrogenase ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Succinate Dehydrogenase Inhibitors

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Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: Comparative molecular modeling study of three distinct families of hybrids

Steroids ◽

10.1016/j.steroids.2010.09.004 ◽

2011 ◽

Vol 76 (1-2) ◽

pp. 94-103 ◽

Author(s):

Josée Provencher-Mandeville ◽

Chhanda Debnath ◽

Sanat K. Mandal ◽

Valérie Leblanc ◽

Sophie Parent ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Design Synthesis ◽

Molecular Modeling Study ◽

Hybrid Molecules ◽

Synthesis And Biological Evaluation ◽

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Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAFV600E inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.08.029 ◽

2014 ◽

Vol 22 (21) ◽

pp. 6201-6208 ◽

Author(s):

Shu-Fu Wang ◽

Yin-Ling Zhu ◽

Ping-Ting Zhu ◽

Jigar A. Makawana ◽

Ya-Liang Zhang ◽

...

Keyword(s):

Biological Evaluation ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling

Bioorganic Chemistry ◽

10.1016/j.bioorg.2018.09.001 ◽

2018 ◽

Vol 81 ◽

pp. 612-629 ◽

Author(s):

Mai Adel ◽

Rabah A.T. Serya ◽

Deena S. Lasheen ◽

Khaled A.M. Abouzid

Keyword(s):

Molecular Modeling ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis

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Arylamide as Potential Selective Inhibitor for Matrix Metalloproteinase 9 (MMP9): Design, Synthesis, Biological Evaluation, and Molecular Modeling

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.9b00630 ◽

2019 ◽

Vol 60 (1) ◽

pp. 349-359 ◽

Author(s):

Maywan Hariono ◽

Rina F. Nuwarda ◽

Muhammad Yusuf ◽

Rollando Rollando ◽

Riris I. Jenie ◽

...

Keyword(s):

Molecular Modeling ◽

Matrix Metalloproteinase ◽

Biological Evaluation ◽

Selective Inhibitor ◽

Matrix Metalloproteinase 9 ◽

Design Synthesis ◽

Metalloproteinase 9

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Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAF V600E inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2018.06.028 ◽

2018 ◽

Vol 28 (14) ◽

pp. 2382-2390 ◽

Author(s):

Chen-Ru Wang ◽

Ze-Feng Wang ◽

Lu Shi ◽

Zhong-Chang Wang ◽

Hai-Liang Zhu

Keyword(s):

Biological Evaluation ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Pyrazole Derivatives

Chemical Biology & Drug Design ◽

10.1111/cbdd.12699 ◽

2016 ◽

Vol 87 (5) ◽

pp. 673-679 ◽

Author(s):

Chunqi Hu ◽

Yali Gao ◽

Wenting Du

Keyword(s):

Biological Evaluation ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRAFV600E and VEGFR-2 dual inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.05.054 ◽

2018 ◽

Vol 155 ◽

pp. 210-228 ◽

Author(s):

Yuanyuan Wang ◽

Shanhe Wan ◽

Zhonghuang Li ◽

Yu Fu ◽

Guangfa Wang ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Dual Inhibitors

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Design, synthesis, biological evaluation and molecular modeling of novel 2-amino-4-(1-phenylethoxy) pyridine derivatives as potential ROS1 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.11.002 ◽

2018 ◽

Vol 143 ◽

pp. 182-199 ◽

Author(s):

Yuanxin Tian ◽

Tingting Zhang ◽

Lifan Long ◽

Zhonghuang Li ◽

Shanhe Wan ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Pyridine Derivatives ◽

Design Synthesis

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