Myeloma‐associated AL amyloidosis presenting with nail dystrophy and scleroderma‐like skin changes

2021 ◽  
Author(s):  
C. Drumm ◽  
M. O’Reilly ◽  
Y. McCartney ◽  
M. O’Kane
Keyword(s):  
Al Amyloidosis ◽  
Nail Dystrophy ◽  
Skin Changes

scholarly journals Acquired Ulcero-Mutilating Bilateral Acro-Osteopathy (Bureau-Barrière Syndrome)

2017 ◽  
Vol 5 (4) ◽  
pp. 558-560
Author(s):  
Georgi Tchernev ◽  
Hristo Mangarov ◽  
Ilia Lozev ◽  
Ivan Pidakev ◽  
Torello Lotti ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Lower Limb ◽  
Alcohol Intake ◽  
Clinical Presentation ◽  
Interdisciplinary Approach ◽  
Bone Lesions ◽  
Nail Dystrophy ◽  
Skin Changes ◽  
Excessive Alcohol ◽  
Excessive Alcohol Intake

We present a 35-year-old male patient with Bureau-Barrière syndrome. Bureau-Barrière syndrome is an ulcero-mutilating acropathy almost invariably associated with excessive alcohol intake. It presents with a triad of trophic skin changes with recurrent ulcerations, bone lesions and nerve damage. The clinical presentation includes chronic painless plantar ulcerations with periulcerous hyperkeratosis, hyperhidrosis, livedoid skin colour, nail dystrophy, widening and infiltration of the toes and common interdigital mycoses. Other non-specific skin changes related to the alcohol consumption are commonly observed as well. The condition affects mainly middle-aged men suffering from alcoholism. Often a bilateral location at the lower limb of male alcoholics has been described, as in our patient. Successful treatment of the Bureau-Barrière syndrome requires an interdisciplinary approach. Cessation of alcohol intake and smoking is of paramount importance.

scholarly journals Nail Biopsy in the Diagnosis of Systemic Amyloidosis

2018 ◽  
Vol 2 (4) ◽  
pp. 252-255
Author(s):  
Cristopher C Briscoe ◽  
Zachary P Nahmias ◽  
Ilana S Rosman ◽  
Milan J Anadkat
Keyword(s):  
Monoclonal Gammopathy ◽  
Conventional Treatment ◽  
Systemic Amyloidosis ◽  
Al Amyloidosis ◽  
Nail Dystrophy ◽  
Hematopoietic Stem ◽  
Nail Changes ◽  
Unknown Significance ◽  
History Of ◽  
Low Threshold

A 60-year-old woman with a 13-year history of monoclonal gammopathy of unknown significance (MGUS) presented with worsening nail dystrophy. Prior workup for systemic amyloidosis had been unrevealing, and no other signs of cutaneous disease were present. Nail biopsy was consistent with amyloid deposition, and the patient subsequently underwent autologous hematopoietic stem cell transplantation for AL amyloidosis. In light of the growing literature regarding nail changes as a presenting sign of systemic amyloidosis and the promising utility of nail biopsy, we suggest a low threshold for biopsy in appropriate patients when nail changes characteristic of amyloidosis are refractory to conventional treatment.

scholarly journals Nail Dystrophy Associated with AL Amyloidosis

2007 ◽  
Vol 46 (8) ◽  
pp. 525-526 ◽  
Author(s):  
Yoichi Hoshino ◽  
Kimihiko Umezawa ◽  
Moriya Machida ◽  
Shun-ichi Shimano ◽  
Teizo Taya ◽  
...  
Keyword(s):  
Al Amyloidosis ◽  
Nail Dystrophy

Lichen striatus with nail dystrophy

1978 ◽  
Vol 114 (6) ◽  
pp. 964b-965
Author(s):  
M. Meyers
Keyword(s):  
Nail Dystrophy ◽  
Lichen Striatus

Skin Changes Help Identify Scleroderma Mimics

2009 ◽  
Vol 40 (7) ◽  
pp. 37
Author(s):  
PATRICE WENDLING
Keyword(s):  
Skin Changes
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