Autoimmune regulator gene, Aire, and its relevance to central tolerance against myelin proteins

2014 ◽  
Vol 5 (3) ◽  
pp. 279-280
Author(s):  
Hirofumi Ochi
Keyword(s):  
Myelin Proteins ◽  
Regulator Gene ◽  
Central Tolerance ◽  
Autoimmune Regulator

scholarly journals NKT cell development in the absence of the autoimmune regulator gene (Aire)

2008 ◽  
Vol 38 (10) ◽  
pp. 2689-2696 ◽  
Author(s):  
Lauren A. Pitt ◽  
Francois-Xavier Hubert ◽  
Hamish S. Scott ◽  
Dale I. Godfrey ◽  
Stuart P. Berzins
Keyword(s):  
Cell Development ◽  
Regulator Gene ◽  
Nkt Cell ◽  
Autoimmune Regulator

Transcriptional programs that control expression of the autoimmune regulator gene Aire

2016 ◽  
Vol 18 (2) ◽  
pp. 161-172 ◽  
Author(s):  
Yonatan Herzig ◽  
Shir Nevo ◽  
Chamutal Bornstein ◽  
Miriam R Brezis ◽  
Sharon Ben-Hur ◽  
...  
Keyword(s):  
Regulator Gene ◽  
Autoimmune Regulator

Association of autoimmune regulator gene polymorphism with susceptibility to rheumatoid arthritis in Egyptian population

2020 ◽  
Vol 68 (2) ◽  
pp. 90-96
Author(s):  
Nermeen Hassan A.Moneim ◽  
Mona Farouk Mansour ◽  
Hanan Hassan Omar ◽  
Marwa Mohamed Fouad ◽  
Lobna Metwally ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphism ◽  
Regulator Gene ◽  
Autoimmune Regulator ◽  
Egyptian Population

scholarly journals Expression of the Autoimmune Regulator Gene and Its Relevance to the Mechanisms of Central and Peripheral Tolerance

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Roberto Perniola
Keyword(s):  
Peripheral Tolerance ◽  
Thymic Epithelial Cells ◽  
Monogenic Disease ◽  
Central Tolerance ◽  
Autoimmune Regulator ◽  
Pathogenic Variants ◽  
Autoimmune Polyendocrine Syndrome ◽  
Murine Homolog ◽  
Genes Encoding ◽  
Medullary Thymic Epithelial Cells

The autoimmune polyendocrine syndrome type 1 (APS-1) is a monogenic disease due to pathogenic variants occurring in the autoimmune regulator (AIRE) gene. Its related protein, AIRE, activates the transcription of genes encoding for tissue-specific antigens (TsAgs) in a subset of medullary thymic epithelial cells: the presentation of TsAgs to the maturating thymocytes induces the apoptosis of the autoreactive clones and constitutes the main form of central tolerance. Dysregulation of thymicAIREexpression in genetically transmitted and acquired diseases other than APS-1 may contribute to further forms of autoimmunity. AsAIREand its murine homolog are also expressed in the secondary lymphoid organs, the extent and relevance of AIRE participation in the mechanisms of peripheral tolerance need to be thoroughly defined.

scholarly journals Lymphotoxin Pathway-Directed, Autoimmune Regulator-Independent Central Tolerance to Arthritogenic Collagen

2006 ◽  
Vol 177 (1) ◽  
pp. 290-297 ◽  
Author(s):  
Robert K. Chin ◽  
Mingzhao Zhu ◽  
Peter A. Christiansen ◽  
Wenhua Liu ◽  
Carl Ware ◽  
...  
Keyword(s):  
Central Tolerance ◽  
Autoimmune Regulator

Peculiar Genotypes of the Autoimmune Regulator Gene in Italian Patients with Autoimmune Polyendocrinopathy-Candidiasis- Ectodermal Dystrophy Syndrome

2013 ◽  
Vol 59 (05+06/2013) ◽  
Author(s):  
Alessia Palma ◽  
Antonino Crinó ◽  
Melania Palombi ◽  
Marco Cappa ◽  
Alessandra Fierabracci
Keyword(s):  
Regulator Gene ◽  
Autoimmune Regulator ◽  
Autoimmune Polyendocrinopathy

scholarly journals Central tolerance to self revealed by the autoimmune regulator

2015 ◽  
Vol 1356 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Alice Y. Chan ◽  
Mark S. Anderson
Keyword(s):  
Central Tolerance ◽  
Autoimmune Regulator
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