Bevacizumab and Bleomycin combination for treatment of orbital lymphatico-venous malformation recalcitrant to sclerosing therapy alone

2018 ◽  
Vol 46 (7) ◽  
pp. 815-816 ◽  
Author(s):  
Hamzah Mustak ◽  
Shoaib Ugradar ◽  
Robert Goldberg ◽  
Daniel Rootman
Keyword(s):  
Venous Malformation ◽  
Sclerosing Therapy

scholarly journals Predictive Factors for Successful Percutaneous Sclerotherapy of Venous and Lymphatic Malformations

2013 ◽  
Vol 19 (1) ◽  
pp. 29-42
Author(s):  
Anchalee Churojana ◽  
Laksanawadee Mahiwan ◽  
Dittapong Songsaeng ◽  
Rujimas Khumtong ◽  
Saowanee Homsud
Keyword(s):  
Treatment Outcome ◽  
Predictive Factors ◽  
Venous Malformation ◽  
Treatment Result ◽  
Focal Lesions ◽  
Lymphatic Malformations ◽  
Sclerosing Agents ◽  
Percutaneous Sclerotherapy ◽  
Good Treatment Outcome ◽  
Sclerosing Therapy

Objectives: To determine the predictive factors for good response outcome of venous (VMs) and lymphatic malformations (LMs) by percutaneous sclerosing therapy and to compare the complications associated with bleomycin versus alcohol treatment. Methods: A retrospective analysis of 225 patients with lymphatic and venous malformation who had treated by percutaneous sclerotherapy using alcohol and/or bleomycin was performed The treatment outcome was graded from 0-3, in orderly of clinical responsiveness by using visual assessment of changing in size and subjective improvement of symptoms. Predictive factors of good treatment outcome were determined by uni- and multivariate analysis which were conducted on sex, age, onset of disease, location, type, characteristic of lesion and sclerosant usage. Results: Of 225 patients, 87.6% were VMs and 12.4% were LMs. VMs were predominating in female (6.2:3.8). Between ethanol and bleomycin, there was no statistical significant of treatment sessions, dose and treatment outcome. (p= .42) Sclerosing therapy provided better response on VMs than LMs. (49.2% and 21.4% respectively, p=.002), and had more effective on focal lesions than diffuse patterns (64.9% and 26.1% respectively p<.001) The gender, onset of disease, locations, characteristic on venography and preceding treatment showed no correlation with treatment result. Major complications of ethanol occurred in 38.6%,including hematuria, gangrene, facial paralysis, pulmonary embolism and death. Minor adverse reactions of bleomycin encountered in 19.8% with hyperpigmentation, flu-like symptom and localized fibrosis. Conclusion: Both absolute alcohol and bleomycin were effective sclerosing agents for percutaneous treatment of venous malformations, but no serious complications encountered with bleomycin. The characteristic of focal single lesion, at any region of body part, can be a predictor for good response.

Percutaneous sclerotherapy for spongiform venous malformations – analysis of patient-evaluated outcome and satisfaction

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 477-483
Author(s):  
Robert Karl Clemens ◽  
Frederic Baumann ◽  
Marc Husmann ◽  
Thomas Oleg Meier ◽  
Christoph Thalhammer ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Medical Records ◽  
Venous Malformation ◽  
Primary Treatment ◽  
Venous Malformations ◽  
Treated Area ◽  
Item Questionnaire ◽  
Percutaneous Sclerotherapy ◽  
Multiple Treatments ◽  
Pain Improvement

Abstract. Background: Congenital venous malformations are frequently treated with sclerotherapy. Primary treatment goal is to control the often size-related symptoms. Functional impairment and aesthetical aspects as well as satisfaction have rarely been evaluated. Patients and methods: Medical records of patients who underwent sclerotherapy of spongiform venous malformations were reviewed and included in this retrospective study. The outcome of sclerotherapy as self-reported by patients was assessed in a 21 item questionnaire. Results: Questionnaires were sent to 166 patients with a total of 327 procedures. Seventy-seven patients (48 %) with a total of 159 procedures (50 %) responded to the survey. Fifty-seven percent of patients were male. The age ranged from 1 to 38.1 years with a median age of 16.4 years. The lower extremities were the most common treated area. Limitations caused by the venous malformation improved in the majority of patients (e.g. pain improvement 87 %, improvement of swelling 83 %) but also worsening of symptoms occurred in a minority of cases. Seventy-seven per cent would undergo sclerotherapy again. Conclusions: Sclerotherapy for treatment of venous malformations results in significant reduction of symptoms. Multiple treatments are often needed, but patients are willing to undergo them.

Arterio-venous malformation in the chest wall: a case report

1991 ◽  
Vol 27 (6) ◽  
pp. 796
Author(s):  
Yun Young Choi ◽  
Kyo Nam Kim ◽  
Heung Suk Seo
Keyword(s):  
Case Report ◽  
Chest Wall ◽  
Venous Malformation ◽  
Arterio Venous Malformation

Intraosseous venous malformation in the anterior mandible: Report of a rare case

2016 ◽  
Vol 3 ◽  
pp. 1-4
Author(s):  
Asha R. Iyengar ◽  
B. V. Subash ◽  
Shalini Dina Simon ◽  
M. H. Vani
Keyword(s):  
Rare Case ◽  
Venous Malformation ◽  
Anterior Mandible

Laryngoscopic KTP Laser Surgery for Adult Hypopharyngolaryngeal Venous Malformation

2013 ◽  
Vol 64 (3) ◽  
pp. 212-218
Author(s):  
Kenichi Watanabe ◽  
Yuuri Okumura ◽  
Koji Hozawa
Keyword(s):  
Laser Surgery ◽  
Venous Malformation ◽  
Ktp Laser

Utility of Sodium Tetradecyl Sulphate for the Management of Oral Venous Malformation

2020 ◽  
Vol 4 (7) ◽  
pp. 127-132
Author(s):  
Krishna Kishor ◽  
Shiv Kishor ◽  
Heera , ◽  
Hiralal Ash ◽  
Kumar Arunesh ◽  
...  
Keyword(s):  
Venous Malformation ◽  
Sodium Tetradecyl Sulphate

Rare Germline GLMN Variants Identified from Blue Rubber Bleb Nevus Syndrome Might Impact mTOR Signaling

2020 ◽  
Vol 22 (10) ◽  
pp. 675-682 ◽  
Author(s):  
Jie Yin ◽  
Zhongping Qin ◽  
Kai Wu ◽  
Yufei Zhu ◽  
Landian Hu ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Sanger Sequencing ◽  
Somatic Mutations ◽  
Venous Malformation ◽  
Underlying Disease ◽  
Mtor Signaling ◽  
Functional Effect ◽  
Germline Variants ◽  
Whole Exome

Backgrounds and Objective: Blue rubber bleb nevus syndrome (BRBN) or Bean syndrome is a rare Venous Malformation (VM)-associated disorder, which mostly affects the skin and gastrointestinal tract in early childhood. Somatic mutations in TEK have been identified from BRBN patients; however, the etiology of TEK mutation-negative patients of BRBN need further investigation. Method: Two unrelated sporadic BRBNs and one sporadic VM were firstly screened for any rare nonsilent mutation in TEK by Sanger sequencing and subsequently applied to whole-exome sequencing to identify underlying disease causative variants. Overexpression assay and immunoblotting were used to evaluate the functional effect of the candidate disease causative variants. Results: In the VM case, we identified the known causative somatic mutation in the TEK gene c.2740C>T (p.Leu914Phe). In the BRBN patients, we identified two rare germline variants in GLMN gene c.761C>G (p.Pro254Arg) and c.1630G>T(p.Glu544*). The GLMN-P254R-expressing and GLMN-E544X-expressing HUVECs exhibited increased phosphorylation of mTOR-Ser-2448 in comparison with GLMN-WTexpressing HUVECs in vitro. Conclusion: Our results demonstrated that rare germline variants in GLMN might contribute to the pathogenesis of BRBN. Moreover, abnormal mTOR signaling might be the pathogenesis mechanism underlying the dysfunction of GLMN protein.

scholarly journals Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

2015 ◽  
Vol 125 (9) ◽  
pp. 3491-3504 ◽  
Author(s):  
Elisa Boscolo ◽  
Nisha Limaye ◽  
Lan Huang ◽  
Kyu-Tae Kang ◽  
Julie Soblet ◽  
...  
Keyword(s):  
Murine Model ◽  
Human Subjects ◽  
Venous Malformation

Cavernous venous malformation of the lacrimal gland

2021 ◽  
Author(s):  
T. Mace ◽  
N. Baldini ◽  
A. Rousseau ◽  
D. Haution ◽  
J.-D. Kün-Darbois
Keyword(s):  
Lacrimal Gland ◽  
Venous Malformation
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