scholarly journals Efficacy of indoor air purification in the treatment of Artemisia pollen‐allergic rhinitis: A randomised, double‐blind, clinical controlled trial

2020 ◽  
Vol 45 (3) ◽  
pp. 394-401 ◽  
Author(s):  
Li Li ◽  
Li Zhang ◽  
Jin‐Han Mo ◽  
Yun‐Ying Li ◽  
Ji‐Yan Xia ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Indoor Air ◽  
Controlled Trial ◽  
Air Purification ◽  
Double Blind ◽  
Artemisia Pollen ◽  
Indoor Air Purification

scholarly journals Efficacy of indoor air purification in treating Artemisia (mugwort) pollen allergic rhinitis: study protocol for a randomised controlled trial

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Qiao-yan Chen ◽  
Li Li ◽  
Li Zhang ◽  
Jin-han Mo ◽  
Zi-feng Yang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Randomised Controlled Trial ◽  
Study Protocol ◽  
Indoor Air ◽  
Controlled Trial ◽  
Air Purification ◽  
Randomised Controlled ◽  
Indoor Air Purification

scholarly journals Intralymphatic immunotherapy with tyrosine-adsorbed allergens: a double-blind, placebo-controlled trial

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Hye Jung Park ◽  
Sae-Hoon Kim ◽  
Yoo Seob Shin ◽  
Chul Hwan Park ◽  
Eun-Suk Cho ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Injection Site ◽  
Symptom Score ◽  
Therapeutic Efficacy ◽  
Controlled Trial ◽  
Life Questionnaire ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Medication Score ◽  
Allergen Extracts

Abstract Background Most previous studies used aluminum hydroxide-absorbed allergen extracts in evaluating the potential therapeutic roles of intralymphatic allergen-specific immunotherapy (ILAIT). In this study, we evaluated the therapeutic efficacy and safety of ILAIT with L-tyrosine-adsorbed allergen extracts of Dermatophagoides farinae, D. pteronyssinus, cat, dog, or mixtures thereof, in patients with allergic rhinitis induced by these allergens. Methods In this randomized, double-blind, placebo-controlled trial, study subjects received three intralymphatic injections of L-tyrosine-adsorbed allergen extracts (active group) or saline (placebo group) at 4-week intervals. Results Although ILAIT reduced daily medication use and skin reactivity to HDM and cat allergens at 4 months after treatment, overall symptom score on a visual analog scale (VAS), sinonasal outcome test-20 (SNOT-20), rhinoconjunctivitis quality of life questionnaire (RQLQ), daily symptom score (dSS), daily medication score (dMS), daily symptom medication score (dSMS), nasal reactivity to HDM allergen, and basophil activity to HDM, cat, and dog allergens at 4 months and 1 year after treatment were similar between the treatment and control groups. Intralymphatic injection was more painful than a venous puncture, and pain at the injection site was the most frequent local adverse event (12.8%); dyspnea and wheezing were the most common systemic adverse events (5.3%). Conclusions ILAIT with L-tyrosine-adsorbed allergen extracts does not exhibit profound therapeutic efficacy in allergic rhinitis and can provoke moderate-to-severe systemic reactions and cause pain at the injection site. Trial registration: clinicaltrials.gov: NCT02665754; date of registration: 28 January 2016

Highly Efficient Ru/CeO2 Catalyst for Formaldehyde Oxidation at Low Temperature and Mechanistic Study

2021 ◽  
Author(s):  
Xiaoxiao Qin ◽  
Xueyan Chen ◽  
Min Chen ◽  
Jiangho Zhang ◽  
Hong He ◽  
...  
Keyword(s):  
Low Temperature ◽  
Indoor Air ◽  
Air Purification ◽  
Mechanistic Study ◽  
Highly Efficient ◽  
Formaldehyde Oxidation ◽  
Indoor Air Purification

Formaldehyde (HCHO) elimination at low temperature is of great interest for indoor air purification. In this work, 1 wt. % Ru supported on CeO2 and Al2O3 catalysts were prepared by...

scholarly journals House-plant placement for indoor air purification and health benefits on asthmatics

2014 ◽  
Vol 29 ◽  
pp. e2014014 ◽  
Author(s):  
Ho-Hyun Kim ◽  
Ji-Yeon Yang ◽  
Jae-Young Lee ◽  
Jung-Won Park ◽  
Kwang-Jin Kim ◽  
...  
Keyword(s):  
Indoor Air ◽  
Health Benefits ◽  
Air Purification ◽  
Indoor Air Purification

Double-Blind, Placebo-Controlled Trial of Reformulated Azelastine Nasal Spray in Patients with Seasonal Allergic Rhinitis

2009 ◽  
Vol 23 (5) ◽  
pp. 512-517 ◽  
Author(s):  
Jonathan A. Bernstein ◽  
Bruce Prenner ◽  
Berrylin J. Ferguson ◽  
Jay Portnoy ◽  
William J. Wheeler ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Spray ◽  
Dose Response ◽  
Seasonal Allergic Rhinitis ◽  
Nasal Congestion ◽  
Controlled Trial ◽  
Taste Masking ◽  
Comparable Efficacy ◽  
Original Formulation ◽  
Double Blind

Background Azelastine nasal spray is a topical antihistamine with a distinctive taste that may be objectionable to some patients. The primary objectives of this clinical trial were (1) to determine if a reformulated azelastine nasal spray (Astepro) with sucralose as a taste-masking agent provides comparable efficacy to the original formulation (Astelin) and (2) to evaluate dose–response relationships between groups. Methods Eight hundred thirty-five patients with seasonal allergic rhinitis were randomized to six treatment groups: (1) original azelastine nasal spray, 1 spray/nostril b.i.d.; (2) reformulated azelastine, 1 spray/nostril b.i.d.; (3) placebo, 1 spray/nostril b.i.d.; (4) original azelastine nasal spray, 2 sprays/nostril b.i.d., (5) reformulated, 2 sprays/nostril b.i.d.; and (6) placebo, 2 sprays/nostril b.i.d. The primary efficacy variable was the change from baseline to day 14 in total nasal symptom score (TNSS) consisting of runny nose, sneezing, itchy nose, and nasal congestion. Results Original azelastine nasal spray and the reformulated spray produced comparable improvements in the TNSS at both dosages. There was a dose-related difference in TNSS comparing the 1- and 2-spray dosages. The percentage changes from baseline in the TNSS in the 2-sprays/nostril dosage groups were 27.9% (p < 0.001) with the reformulated nasal spray, 23.5% (p < 0.01) with the original formulation, and 15.4% with placebo. The incidence of bitter taste was 7% with the reformulated spray and 8% with the original at the 2-sprays/nostril dosage. Conclusion The results of this study showed efficacy both with original azelastine nasal spray and with the reformulated nasal spray and a clear dose–response difference between the 1- and 2-spray dosages.

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