Background: The standard irradiation dose to the elective lymph node area (ELNA) in locally patients with advanced head and neck squamous cell carcinoma (LA-HNSCC) to control lymph node micrometastases (LN-MM) has not changed since it was empirically determined in the 1950s. We investigated the optimal irradiation dose for controlling LN-MM in ELNAs. Patients and Methods: The pattern of recurrence of LA-HNSCC was retrospectively evaluated in patients who underwent concurrent chemoradiotherapy with cisplatin or radiation therapy alone. Results: In total, 162 patients were enrolled. The median observation period was 34 months. No recurrence was found in ELNAs. After propensity score matching, a cisplatin dose of ≥200 mg/m2 yielded a significantly higher overall survival rate (p≤0.001) and locoregional control rate (p=0.034) than did a dose of <100 mg/m2. Conclusion: CCRT with a cisplatin dose of ≥200 mg/m2 can reduce the irradiation dose to 40-44 Gy at 2 Gy per fraction to control LN-MM.
A Phase Ii Study of Concurrent Chemoradiotherapy with Weekly Low-Dose Cisplatin and Docetaxel in Locally Advanced Unresectable Head and Neck Carcinoma