Terminal ileitis and multiple strictures in Crohn’s disease: technical notes for a side‐to‐side strictureplasty over the ileocaecal valve – a video vignette

2020 ◽  
Vol 22 (12) ◽  
pp. 2343-2343
Author(s):  
Sébastien Frey ◽  
Alexandre Maubert ◽  
Xavier Hebuterne ◽  
Emmanuel Benizri ◽  
Amine Rahili
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Terminal Ileitis ◽  
Ileocaecal Valve ◽  
Video Vignette

ISOLATED TERMINAL ILEITIS AT COLONOSCOPY – DOES ULCERATION PREDICT CROHN’S DISEASE?

2020 ◽  
Author(s):  
R Patel ◽  
KM Ang ◽  
S Modelina ◽  
R Canda ◽  
S Musa ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Terminal Ileitis

P058 ISOLATED TERMINAL ILEITIS AT COLONOSCOPY – WHAT FACTORS PREDICT A NEW DIAGNOSIS OF CROHN’S DISEASE?

2020 ◽  
Vol 158 (3) ◽  
pp. S23
Author(s):  
Rajan Patel ◽  
Kar Mun Ang ◽  
Saadiq Moledina ◽  
Saif Musa ◽  
Akeel Alisa ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Terminal Ileitis ◽  
New Diagnosis

Injection of freshly collected autologous adipose tissue for treatment of perianal fistula in a patient with Crohn's disease – a video vignette

2019 ◽  
Vol 21 (8) ◽  
pp. 981-982 ◽  
Author(s):  
H. Elfeki ◽  
H. T. Hougaard ◽  
J. Duelund‐Jakobsen ◽  
L. Lundby
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Perianal Fistula ◽  
Video Vignette

P058 ISOLATED TERMINAL ILEITIS AT COLONOSCOPY – WHAT FACTORS PREDICT A NEW DIAGNOSIS OF CROHN’S DISEASE?

2020 ◽  
Vol 26 (Supplement_1) ◽  
pp. S14-S14
Author(s):  
Rajan Patel ◽  
Kar Mun Ang ◽  
Saadiq Moledina ◽  
Saif Musa ◽  
Akeel Alisa ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Terminal Ileum ◽  
Binary Logistic Regression ◽  
Poor Correlation ◽  
Colonic Disease ◽  
Chi Square ◽  
Terminal Ileitis ◽  
Faecal Calprotectin ◽  
New Diagnosis

Abstract Background Faecal calprotectin (FC) is a biomarker elevated in active inflammatory bowel disease (IBD). FC is more sensitive in colonic than small bowel IBD. Ileo-colonoscopy is usually performed to confirm a diagnosis of IBD. Isolated non-specific terminal ileitis is often inconclusive despite biopsy. We aimed to assess the factors that predict terminal ileal Crohn’s disease after ileitis is seen at colonoscopy. Methods A single centre retrospective study of all endoscopic cases of isolated terminal ileitis diagnosed at colonoscopy over a 4 year period (January 2015 – December 2018) was performed. Data was obtained from the Unisoft Endoscopy reporting software. Statistical analyses included chi-square, student t-test and binary logistic regression. Faecal calprotectin, CRP and histology were noted. >150μg/mg was used as a cut off for elevated FC. Results 139 cases were identified and exclusion criteria were applied (known Crohn’s disease, colonic disease). 74 cases were included for analysis. The mean age was 43.9. 44 (59.5%) of the cases were women. 38 (51.4%) had FC performed of which 27 (71.1%) had a FC >150μg/mg. 60 (81.1%) cases had macroscopic terminal ileum ulcers, 9 (15%) of these had histological evidence of ulceration. Subsequent diagnoses of Crohn’s disease were made in 15 (20.3%) patients. Odds ratio of 1.28 (p = 0.016, Cl 0.45-0.047) in the TI ulcers + FC >150μg/mg vs. no TI ulcers + FC <150μg/mg. Conclusion 1 in 5 patients with isolated terminal ileitis were subsequently diagnosed with Crohn’s disease. Almost 90% of these new cases had a faecal calprotectin >150μg/mg. There is poor correlation between endoscopic and histological terminal ileum ulceration. We conclude that terminal ileal ulceration in combination with faecal calprotectin >150μg/mg increases the likelihood of a new diagnosis of Crohn’s disease.

scholarly journals AB007. Near-infrared bowel perfusion angiography during laparoscopic ileocolic resection for Crohn’s disease—video vignette

2020 ◽  
Vol 4 ◽  
pp. AB007-AB007
Author(s):  
Alan Martin Keyes ◽  
Mohammad Faraz Khan ◽  
Michael Eamon Kelly ◽  
Ronan Cahill
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Near Infrared ◽  
Ileocolic Resection ◽  
Bowel Perfusion ◽  
Video Vignette

scholarly journals Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn’s Disease

2020 ◽  
Vol 27 (1) ◽  
pp. 12-24
Author(s):  
Maya Olaisen ◽  
Arnar Flatberg ◽  
Atle van Beelen Granlund ◽  
Elin Synnøve Røyset ◽  
Tom Christian Martinsen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Beta Diversity ◽  
Ileocecal Valve ◽  
Alpha Diversity ◽  
Normal Mucosa ◽  
Ileocecal Resection ◽  
Ileal Mucosa ◽  
Terminal Ileitis ◽  
Endoscopic Recurrence

Abstract Background Microbiota is most likely essential in the pathogenesis of Crohn’s disease (CD). Fecal diversion after ileocecal resection (ICR) protects against CD recurrence, whereas infusion of fecal content triggers inflammation. After ICR, the majority of patients experience endoscopic recurrence in the neoterminal ileum, and the ileal microbiome is of particular interest. We have assessed the mucosa-associated microbiome in the inflamed and noninflamed ileum in patients with CD. Methods Mucosa-associated microbiome was assessed by 16S rRNA sequencing of biopsies sampled 5 and 15 cm orally of the ileocecal valve or ileocolic anastomosis. Results Fifty-one CD patients and forty healthy controls (HCs) were included in the study. Twenty CD patients had terminal ileitis, with endoscopic inflammation at 5 cm, normal mucosa at 15 cm, and no history of upper CD involvement. Crohn’s disease patients (n = 51) had lower alpha diversity and separated clearly from HC on beta diversity plots. Twenty-three bacterial taxa were differentially represented in CD patients vs HC; among these, Tyzzerella 4 was profoundly overrepresented in CD. The microbiome in the inflamed and proximal noninflamed ileal mucosa did not differ according to alpha diversity or beta diversity. Additionally, no bacterial taxa were differentially represented. Conclusions The microbiome is similar in the inflamed and proximal noninflamed ileal mucosa within the same patients. Our results support the concept of CD-specific microbiota alterations and demonstrate that neither ileal sublocation nor endoscopic inflammation influence the mucosa-associated microbiome.

Accuracy of retrograde ileoscopy in the evaluation of Crohn's disease terminal ileitis. A perspective study

2001 ◽  
Vol 120 (5) ◽  
pp. A275
Author(s):  
Andrea Cocco ◽  
Paola Cosimo ◽  
Gabriede Capurso ◽  
Giancarlo D'Ambra ◽  
Adriana Marcheggiano ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Terminal Ileitis
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