Injection of freshly collected autologous adipose tissue for treatment of perianal fistula in a patient with Crohn's disease – a video vignette

2019 ◽  
Vol 21 (8) ◽  
pp. 981-982 ◽  
Author(s):  
H. Elfeki ◽  
H. T. Hougaard ◽  
J. Duelund‐Jakobsen ◽  
L. Lundby
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Perianal Fistula ◽  
Video Vignette

scholarly journals Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn’s disease: a retrospective observational study

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Min Young Park ◽  
Yong Sik Yoon ◽  
Jong Lyul Lee ◽  
Sang Hyoung Park ◽  
Byong Duk Ye ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Tumor Necrosis ◽  
Perianal Fistula ◽  
Cell Group ◽  
Fistula Closure ◽  
Necrosis Factor ◽  
Seton Placement

Abstract Background Perianal fistula is one of the most common complications in Crohn’s disease, and various medical and surgical treatments are being tried. The aim of this study was to compare the perianal fistula closure rates following treatment with anti-tumor necrosis factor (TNF) agents or autologous adipose tissue-derived stem cell (auto-ASC) transplantation with Crohn’s disease (CD). Methods CD patients who underwent seton placement for perianal fistula from January 2015 to December 2019 at a tertiary referral center were retrospectively reviewed. Patients were divided into two groups, one that received sequential treatments with anti-TNF agents (anti-TNF group) and the other that underwent auto-ASC transplantation (stem cell group). Clinical variables and fistula closure rates were compared in the two groups. Results Of the 69 patients analyzed, 39 were treated with anti-TNF agents and 30 underwent auto-ASC transplantation. Compared with the stem cell group, patients in the anti-TNF group were older (p=0.028), were more frequently male (p=0.019), had fistulas with more penetrating behavior (p=0.002), had undergone surgery more frequently (p=0.010), and had a shorter interval from seton placement to intended treatment (p<0.001). During a median follow-up of 46 months (range, 30–52.5 months), fistula closure rates were significantly faster (83.3% vs. 23.1%, p<0.001), and the mean interval from seton placement to fistula closure significantly shorter (14 vs. 37 months, p<0.001) in the stem cell than in the anti-TNF group. Three patients experienced fistula recurrence, all in the stem cell group. Conclusions Medical treatment using anti-TNF agents and auto-ASC transplantation are feasible treatment options after seton placement for Crohn’s perianal fistula. However, the closure rate was significantly faster and the time to closure significantly shorter in patients who underwent auto-ASC transplantation than medical treatment. Trial registration This study was retrospectively registered and approved by the Institutional Review Board of Asan Medical Center, number 2020-1059.

scholarly journals Fistula-Related Cancer in Crohn’s Disease: A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1445
Author(s):  
Andromachi Kotsafti ◽  
Melania Scarpa ◽  
Imerio Angriman ◽  
Ignazio Castagliuolo ◽  
Antonino Caruso
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Hpv Vaccination ◽  
Perianal Fistula ◽  
Hpv Infection ◽  
Poor Quality ◽  
Colorectal Disease ◽  
Small Series ◽  
Chron's Disease

Perianal fistulizing Crohn’s disease is a very disabling condition with poor quality of life. Patients with perianal fistulizing Crohn’s disease are also at risk of perianal fistula-related squamous cell carcinoma (SCC). Cancer arising at the site of a chronic perianal fistula is rare in patients with Crohn’s disease and there is a paucity of data regarding its incidence, diagnosis and management. A systematic review of the literature was undertaken using Medline, Embase, Pubmed, Cochrane and Web of Science. Several small series have described sporadic cases with perianal cancer in Crohn’s disease. The incidence rate of SCC related to perianal fistula was very low (<1%). Prognosis was poor. Colorectal disease, chronic perianal disease and HPV infection were possible risk factors. Fistula-related carcinoma in CD (Chron’s disease) can be very difficult to diagnose. Examination may be limited by pain, strictures and induration of the perianal tissues. HPV is an important risk factor with a particular carcinogenesis mechanism. MRI can help clinicians in diagnosis. Examination under anesthesia is highly recommended when findings, a change in symptoms, or simply long-standing disease in the perineum are present. Future studies are needed to understand the role of HPV vaccination in preventing fistula-related cancer.

scholarly journals Mucinous adenocarcinoma arising from recurrent perianal fistula in patient with Crohn's disease: case report

2014 ◽  
Vol 34 (3) ◽  
pp. 185-188
Author(s):  
Suelene Suassuna Silvestre de Alencar ◽  
Romualdo da Silva Corrêa ◽  
Cátia de França Bezerra ◽  
Marcelo José Carlos Alencar ◽  
Cristiana Soares Nunes ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Mucinous Adenocarcinoma ◽  
Perianal Fistula ◽  
Disease Case

Sa2018 - Radiomic Texture Analysis Shows Differential Expression within Visceral Adipose Tissue Regions on MRI Reflecting Severity of Pediatric Crohn's Disease

2018 ◽  
Vol 154 (6) ◽  
pp. S-448-S-449 ◽  
Author(s):  
Jacob A. Kurowski ◽  
Iulia Barbur ◽  
Rishi Gupta ◽  
Kaustav Bera ◽  
Rajat Thawani ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Differential Expression ◽  
Texture Analysis ◽  
Visceral Adipose Tissue ◽  
Visceral Adipose

scholarly journals P-052: Accumulation of intra-abdominal adipose tissue in pediatric Crohn’s disease

2014 ◽  
Vol 8 ◽  
pp. S412
Author(s):  
K. Frivolt ◽  
H. Hetterich ◽  
T. Schwerd ◽  
M.S. Hajji ◽  
P. Bufler ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Abdominal Adipose Tissue

Safety of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Complex Perianal Fistulas Not Associated With Crohn’s Disease

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Víctor Manuel Maciel Gutiérrez ◽  
Sergio Giovanni Gutiérrez Guillen ◽  
Manuel Willebaldo Centeno Flores ◽  
Jesús Alonso Valenzuela Pérez ◽  
Francisco Manuel Abarca Rendón ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Perianal Fistulas
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