scholarly journals Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease

2020 ◽  
Author(s):  
Wenrui Qu ◽  
Baoming Yuan ◽  
Jun Liu ◽  
Qianqian Liu ◽  
Xi Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Receptor Subunit ◽  
Ampa Receptor Subunit

scholarly journals Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease

2021 ◽  
Vol 22 (15) ◽  
pp. 7887
Author(s):  
Carmen Nanclares ◽  
Andres Mateo Baraibar ◽  
Alfonso Araque ◽  
Paulo Kofuji
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Synaptic Plasticity ◽  
Neuronal Excitability ◽  
Active Role ◽  
Ionic Homeostasis ◽  
Neuronal Communication ◽  
Structural Support

Recent studies implicate astrocytes in Alzheimer’s disease (AD); however, their role in pathogenesis is poorly understood. Astrocytes have well-established functions in supportive functions such as extracellular ionic homeostasis, structural support, and neurovascular coupling. However, emerging research on astrocytic function in the healthy brain also indicates their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters. Here, we review how this “active” role of astrocytes at synapses could contribute to synaptic and neuronal network dysfunction and cognitive impairment in AD.

scholarly journals Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression

2017 ◽  
Vol 37 (24) ◽  
pp. 5809-5821 ◽  
Author(s):  
Amber L. LaCrosse ◽  
Sinead M. O'Donovan ◽  
Marian T. Sepulveda-Orengo ◽  
Robert E. McCullumsmith ◽  
Kathryn J. Reissner ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Subunit ◽  
Cocaine Seeking ◽  
Ampa Receptor Subunit ◽  
Subunit Expression

scholarly journals Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex

2012 ◽  
Vol 1435 ◽  
pp. 1-7 ◽  
Author(s):  
Tomoyuki Miyazaki ◽  
Misako Kunii ◽  
Hirobumi Tada ◽  
Akane Sano ◽  
Yoshiyuki Kuroiwa ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Barrel Cortex ◽  
Receptor Subunit ◽  
Ampa Receptor Subunit
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