Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease
Keyword(s):
Recent studies implicate astrocytes in Alzheimer’s disease (AD); however, their role in pathogenesis is poorly understood. Astrocytes have well-established functions in supportive functions such as extracellular ionic homeostasis, structural support, and neurovascular coupling. However, emerging research on astrocytic function in the healthy brain also indicates their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters. Here, we review how this “active” role of astrocytes at synapses could contribute to synaptic and neuronal network dysfunction and cognitive impairment in AD.
2017 ◽
Vol 12
(4)
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pp. 268-285
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2019 ◽
Vol 48
(1-2)
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pp. 56-67
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2012 ◽
Vol 89
(3-4)
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pp. 144-149
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2008 ◽
Vol 190
(5)
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pp. 1369-1374
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Keyword(s):
2010 ◽
Vol 20
(1)
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pp. 175-183
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