scholarly journals Dental pulp stem cell‐derived exosomes alleviate cerebral ischaemia‐reperfusion injury through suppressing inflammatory response

2021 ◽  
Author(s):  
Song Li ◽  
Lihua Luo ◽  
Yan He ◽  
Ruohan Li ◽  
Yangfan Xiang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Inflammatory Response ◽  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Dental Pulp ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Dental Pulp Stem Cell

scholarly journals XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition

2019 ◽  
Vol 58 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Yue-Ming Zhang ◽  
Xiao-Yu Qu ◽  
Li-Na Tao ◽  
Jing-Hui Zhai ◽  
Huan Gao ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Reperfusion Injury ◽  
Response Inhibition ◽  
Cerebral Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Xingnaojing Injection

Protective effect of dl-3n-butylphthalide preconditioning on focal cerebral ischaemia-reperfusion injury in rats

2013 ◽  
Vol 25 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Pei-Lei Zhang ◽  
Hai-Tao Lu ◽  
Jun-Gong Zhao ◽  
Ming-Hua Li
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Neurological Deficit ◽  
Cerebral Ischaemia ◽  
Sham Operation ◽  
Focal Cerebral Ischaemia ◽  
Vegf Expression ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Infarction Volume

ObjectiveTo investigate the effect of dl-3n-butylphthalide (NBP) on the protection of cerebral tissue and possible mechanism on ischaemia-reperfusion injury, and to find out whether NBP therapy can extend the reperfusion window in an experimental stroke model in rats.MethodsSeventy-two Sprague-Dawley rats were randomly divided into sham operation, ischaemia-reperfusion and ischaemia-reperfusion with NBP groups. Focal cerebral ischaemia was induced using the modified intraluminal thread method and maintained for 2, 3 or 4 h. The ischaemia-reperfusion group received reperfusion immediately after ischaemia-reperfusion. The NBP group received intraperitoneal injection of NBP immediately after ischaemia, followed by reperfusion. The sham operation group received only injection of physiological saline. The cerebral infarction volume and neurological deficit were analysed, and vascular endothelial growth factor (VEGF) expression in brain tissues was visualised by immunohistochemistry.ResultsNBP treatment caused a significant decrease in both infarction volume and neurological deficit compared with the ischaemia-reperfusion group at corresponding time points in each (p < 0.05). In the NBP group, the infarction volume and neurological deficit did not change with different ischaemia times. The expression of VEGF was significantly decreased in the ischaemia-reperfusion group compared with the sham group (p < 0.01), while this change was partly prevented in the NBP group (p < 0.01). The expression of VEGF in brain tissue in both the NBP and ischaemia-reperfusion groups gradually decreased when the ischaemic period was prolonged.ConclusionNBP treatment has a protective effect against cerebral ischaemia; this possible mechanism maybe related to the VEGF expression and may extend the reperfusion window for subsequent salvage of cerebral ischaemia by reperfusion.

The lncRNA ROR/miR-124-3p/TRAF6 axis regulated the ischaemia reperfusion injury-induced inflammatory response in human cardiac myocytes

2019 ◽  
Vol 51 (6) ◽  
pp. 381-392 ◽  
Author(s):  
Ying-Ping Liang ◽  
Qin Liu ◽  
Guo-Hai Xu ◽  
Jing Zhang ◽  
Yong Chen ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Reperfusion Injury ◽  
Cardiac Myocytes ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Effect of focal mild hypothermia on expression of MMP-9, TIMP-1, Tau-1 and β-APP in rats with cerebral ischaemia/reperfusion injury

Brain Injury ◽  
2013 ◽  
Vol 27 (10) ◽  
pp. 1190-1198 ◽  
Author(s):  
Jing-kun Zhao ◽  
Fu-lin Guan ◽  
Shu-rong Duan ◽  
Ji-wei Zhao ◽  
Rui-hong Sun ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Mild Hypothermia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling

2020 ◽  
Vol 11 ◽  
Author(s):  
Hailong Yu ◽  
Lilong Song ◽  
Xiang Cao ◽  
Wei Li ◽  
Yuanyuan Zhao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals HDAC 9 exacerbates endothelial injury in cerebral ischaemia/reperfusion injury

2016 ◽  
Vol 20 (6) ◽  
pp. 1139-1149 ◽  
Author(s):  
Weichen Shi ◽  
Xinbing Wei ◽  
Ziying Wang ◽  
Huirong Han ◽  
Yi Fu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Endothelial Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats

2017 ◽  
Vol 293 ◽  
pp. 115-123 ◽  
Author(s):  
X.D. Ma ◽  
L.H. Hang ◽  
D.H. Shao ◽  
W.W. Shu ◽  
X.L. Hu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion
Sign in / Sign up

Export Citation Format

Share Document