scholarly journals Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase‐3β‐mediated activation of autophagy

2020 ◽  
Vol 177 (6) ◽  
pp. 1434-1452 ◽  
Author(s):  
Jianmei Gao ◽  
Long Long ◽  
Fan Xu ◽  
Linying Feng ◽  
Yuangui Liu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Ischaemia Reperfusion Injury ◽  
Phosphodiesterase 5 Inhibitor ◽  
Ischaemia Reperfusion ◽  
Icariside Ii ◽  
Phosphodiesterase 5

Glycogen synthase kinase-3β inhibition attenuates the development of ischaemia/reperfusion injury of the gut

2007 ◽  
Vol 33 (5) ◽  
pp. 880-893 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Emanuela Mazzon ◽  
Emanuela Esposito ◽  
Carmelo Muià ◽  
Maha Abdelrahman ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Protective effect of dl-3n-butylphthalide preconditioning on focal cerebral ischaemia-reperfusion injury in rats

2013 ◽  
Vol 25 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Pei-Lei Zhang ◽  
Hai-Tao Lu ◽  
Jun-Gong Zhao ◽  
Ming-Hua Li
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Neurological Deficit ◽  
Cerebral Ischaemia ◽  
Sham Operation ◽  
Focal Cerebral Ischaemia ◽  
Vegf Expression ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Infarction Volume

ObjectiveTo investigate the effect of dl-3n-butylphthalide (NBP) on the protection of cerebral tissue and possible mechanism on ischaemia-reperfusion injury, and to find out whether NBP therapy can extend the reperfusion window in an experimental stroke model in rats.MethodsSeventy-two Sprague-Dawley rats were randomly divided into sham operation, ischaemia-reperfusion and ischaemia-reperfusion with NBP groups. Focal cerebral ischaemia was induced using the modified intraluminal thread method and maintained for 2, 3 or 4 h. The ischaemia-reperfusion group received reperfusion immediately after ischaemia-reperfusion. The NBP group received intraperitoneal injection of NBP immediately after ischaemia, followed by reperfusion. The sham operation group received only injection of physiological saline. The cerebral infarction volume and neurological deficit were analysed, and vascular endothelial growth factor (VEGF) expression in brain tissues was visualised by immunohistochemistry.ResultsNBP treatment caused a significant decrease in both infarction volume and neurological deficit compared with the ischaemia-reperfusion group at corresponding time points in each (p < 0.05). In the NBP group, the infarction volume and neurological deficit did not change with different ischaemia times. The expression of VEGF was significantly decreased in the ischaemia-reperfusion group compared with the sham group (p < 0.01), while this change was partly prevented in the NBP group (p < 0.01). The expression of VEGF in brain tissue in both the NBP and ischaemia-reperfusion groups gradually decreased when the ischaemic period was prolonged.ConclusionNBP treatment has a protective effect against cerebral ischaemia; this possible mechanism maybe related to the VEGF expression and may extend the reperfusion window for subsequent salvage of cerebral ischaemia by reperfusion.

Effect of focal mild hypothermia on expression of MMP-9, TIMP-1, Tau-1 and β-APP in rats with cerebral ischaemia/reperfusion injury

Brain Injury ◽  
2013 ◽  
Vol 27 (10) ◽  
pp. 1190-1198 ◽  
Author(s):  
Jing-kun Zhao ◽  
Fu-lin Guan ◽  
Shu-rong Duan ◽  
Ji-wei Zhao ◽  
Rui-hong Sun ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Mild Hypothermia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling

2020 ◽  
Vol 11 ◽  
Author(s):  
Hailong Yu ◽  
Lilong Song ◽  
Xiang Cao ◽  
Wei Li ◽  
Yuanyuan Zhao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Ventricular Hypertrophy Abrogates Intralipid-Induced Cardioprotection by Alteration of Reperfusion Injury Salvage Kinase/Glycogen Synthase Kinase 3β Signal

Shock ◽  
2014 ◽  
Vol 41 (5) ◽  
pp. 435-442 ◽  
Author(s):  
Lei-Lei Ma ◽  
Hong-Wei Ge ◽  
Fei-Juan Kong ◽  
Ling-Bo Qian ◽  
Bang-Chuan Hu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ventricular Hypertrophy ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Reperfusion Injury Salvage Kinase
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