Early aspirin initiation following heart transplantation is associated with reduced risk of allograft vasculopathy during long-term follow-up

2017 ◽  
Vol 31 (12) ◽  
pp. e13133 ◽  
Author(s):  
Yael Peled ◽  
Jacob Lavee ◽  
Eugenia Raichlin ◽  
Moshe Katz ◽  
Michael Arad ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Allograft Vasculopathy ◽  
Long Term Follow Up ◽  
Reduced Risk

Early Aspirin Initiation Following Heart Transplantation Decreases the Risk of Allograft Vasculopathy During Long-Term Follow-Up

2017 ◽  
Vol 36 (4) ◽  
pp. S142
Author(s):  
Y. Peled ◽  
J. Lavee ◽  
E. Raichlin ◽  
M. Katz ◽  
Y. Shemesh ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Allograft Vasculopathy ◽  
Long Term Follow Up

De Novo Anti-HLA Antibodies After Heart Transplantation Are Associated With Adverse Events in the Long-term Follow-up of Cardiac Transplant Recipients

2016 ◽  
Vol 48 (9) ◽  
pp. 3030-3032 ◽  
Author(s):  
E. Solé-González ◽  
S. Mirabet ◽  
V. Brossa ◽  
L. López-López ◽  
M. Rivas-Lasarte ◽  
...  
Keyword(s):  
Adverse Events ◽  
Heart Transplantation ◽  
De Novo ◽  
Cardiac Transplant ◽  
Transplant Recipients ◽  
Hla Antibodies ◽  
Long Term Follow Up

scholarly journals The Predictive Value of Depression in the Years After Heart Transplantation for Mortality During Long-Term Follow-Up

2019 ◽  
Vol 81 (6) ◽  
pp. 513-520 ◽  
Author(s):  
Britta S. Bürker ◽  
Lars Gullestad ◽  
Einar Gude ◽  
Odd E. Havik ◽  
Anne Relbo Authen ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Predictive Value ◽  
Long Term Follow Up

scholarly journals Three decades of heart transplantation in Scandinavia: long-term follow-up

2013 ◽  
Vol 15 (3) ◽  
pp. 308-315 ◽  
Author(s):  
Göran Dellgren ◽  
Odd Geiran ◽  
Karl Lemström ◽  
Finn Gustafsson ◽  
Hans Eiskjaer ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Long Term Follow Up

scholarly journals Long-term follow-up after heart transplantation in very young children

2013 ◽  
Vol 106 (8-9) ◽  
pp. 463
Author(s):  
M. Veyrier ◽  
C. Ducreux ◽  
R. Henaine ◽  
A. Bozio ◽  
F. Sassolas ◽  
...  
Keyword(s):  
Young Children ◽  
Heart Transplantation ◽  
Very Young Children ◽  
Long Term Follow Up

Atrioventricular orthotopic heart transplantation: long term follow up of a prospective randomised clinical trial

2003 ◽  
Vol 22 (1) ◽  
pp. S171
Author(s):  
P.C Jansz ◽  
J.I Ferguson ◽  
K.K Dhital ◽  
J Wallwork ◽  
S.R Large
Keyword(s):  
Clinical Trial ◽  
Heart Transplantation ◽  
Randomised Clinical Trial ◽  
Orthotopic Heart Transplantation ◽  
Long Term Follow Up

Long-term follow-up of patients with tetralogy of Fallot and implantable cardioverter defibrillator

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
V Waldmann ◽  
A Bouzeman ◽  
G Duthoit ◽  
R Koutbi ◽  
F Bessiere ◽  
...  
Keyword(s):  
Primary Prevention ◽  
Secondary Prevention ◽  
Heart Transplantation ◽  
Implantable Cardioverter Defibrillator ◽  
Tetralogy Of Fallot ◽  
Icd Therapy ◽  
Cardioverter Defibrillator ◽  
Long Term Follow Up

Abstract Background Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, and sudden cardiac death represents an important mode of death in these patients. Data evaluating the implantable cardioverter defibrillator (ICD) in this patient population remain scarce. Purpose We aimed to describe long-term follow-up of patients with TOF and ICD through a large nationwide registry. Methods Nationwide Registry including all TOF patients with an ICD initiated in 2010. The primary outcome was the first appropriate ICD therapy. Secondary outcomes included ICD-related complications, heart transplantation, and death. Clinical events were centrally adjudicated by a blinded committee. Cox proportional hazard models were used to identify predictors of appropriate ICD therapies and ICD-related complications. Results A total of 165 patients (mean age 42.2±13.3 years, 70.1% males) were included from 40 centers, including 104 (63.0%) in secondary prevention. During a median (IQR) follow-up of 6.8 (2.5–11.4) years, 78 (47.3%) patients received at least one appropriate ICD therapy, giving an annual incidence of 10.5% (7.1% and 12.5% in primary and secondary prevention, respectively, p=0.03). Overall, 71 (43.0%) patients presented with at least one complication, including inappropriate ICD shocks in 42 (25.5%) patients and lead/generator dysfunction in 36 (21.8%) patients. Among 61 (37.0%) primary prevention patients, the annual rate of appropriate ICD therapies was 4.1%, 5.3%, 9.5%, and 13.3% in patients with respectively no, one, two, or ≥ three guideline-recommended risk factors. In our cohort, QRS fragmentation was the only independent predictor of appropriate ICD therapies (HR 4.34, 95% CI 1.42–13.23), and its integration in a model with current criteria increased the area under the curve from 0.61 to 0.72 (p=0.006). No patient with left ventricular ejection fraction (LVEF) ≤35% without at least one other risk factor had appropriate ICD therapy. Patients with congestive heart failure and/or reduced LVEF had a higher risk of non-sudden death or heart transplantation (HR=11.01, 95% CI: 2.96–40.95). Conclusions Our findings demonstrate high rates of appropriate therapies in TOF patients with an ICD, including in primary prevention. The considerable long-term burden of ICD-related complications, however, underlines the need for careful candidate selection. A combination of easy-to-use criteria might improve risk stratification beyond low LVEF. Freedom from appropriate ICD therapy Funding Acknowledgement Type of funding source: None

Body mass index in middle life and future risk of hospital admission for psychoses or depression: findings from the Renfrew/Paisley study

2007 ◽  
Vol 37 (8) ◽  
pp. 1151-1161 ◽  
Author(s):  
DEBBIE A. LAWLOR ◽  
CAROLE L. HART ◽  
DAVID J. HOLE ◽  
DAVID GUNNELL ◽  
GEORGE DAVEY SMITH
Keyword(s):  
Body Mass Index ◽  
Hospital Admission ◽  
Body Mass ◽  
Hospital Admissions ◽  
Long Term Follow Up ◽  
Psychiatric Outcomes ◽  
Future Hospital ◽  
Reduced Risk

ABSTRACTBackgroundThere is evidence that greater body mass index (BMI) protects against depression, schizophrenia and suicide. However, there is a need for prospective studies.MethodWe examined the association of BMI with future hospital admissions for psychoses or depression/anxiety disorders in a large prospective study of 7036 men and 8327 women. Weight and height were measured at baseline (1972–76) when participants were aged 45–64. Follow-up was for a median of 29 years.ResultsGreater BMI and obesity were associated with a reduced risk of hospital admission for psychoses and depression/anxiety in both genders, with the magnitude of these associations being the same for males and females. With adjustment for age, sex, smoking and social class, a 1 standard deviation (s.d.) greater BMI at baseline was associated with a rate ratio of 0·91 [95% confidence interval (CI) 0·82–1·01] for psychoses and 0·87 (95% CI 0·77–0·98) for depression/anxiety. Further adjustment for baseline psychological distress and total cholesterol did not alter these associations.ConclusionsOur findings add to the growing body of evidence that suggests that greater BMI is associated with a reduced risk of major psychiatric outcomes. Long-term follow-up of participants in randomized controlled trials of interventions that effectively result in weight loss and the use of genetic variants that are functionally related to obesity as instrumental variables could help to elucidate whether these associations are causal.

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