Factors affecting sensitization following kidney allograft failure

2021 ◽  
Author(s):  
Neetika Garg ◽  
Kelley Viney ◽  
John Burger ◽  
Luis Hidalgo ◽  
Sandesh Parajuli ◽  
...  
Keyword(s):  
Kidney Allograft ◽  
Factors Affecting ◽  
Allograft Failure

scholarly journals Returning to dialysis after kidney allograft failure: the experience of the Italian Registry of Paediatric Chronic Dialysis

2021 ◽  
Author(s):  
Edoardo La Porta ◽  
Ester Conversano ◽  
Daniela Zugna ◽  
Roberta Camilla ◽  
Raffaella Labbadia ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Chronic Dialysis ◽  
Supplementary Information ◽  
Dialysis Modality ◽  
Specific Population ◽  
Kidney Allograft ◽  
Allograft Failure ◽  
Younger Age ◽  
Complicated Course ◽  
Significant Mortality

Abstract Background The need for dialysis after kidney allograft failure (DAGF) is among the top five reasons for dialysis initiation, making this an important topic in clinical nephrology. However, data are scarce on dialysis choice after transplantation and clinical outcomes for DAGF in children. Methods Patients receiving chronic dialysis < 18 years were recorded from January 1991 to January 2019 by the Italian Registry of Pediatric Chronic Dialysis (IRPCD). We investigated factors influencing choice of dialysis modality, patient outcome in terms of mortality, switching dialysis modality, and kidney transplantation. Results Among 118 patients receiving DAGF, 41 (35%) were treated with peritoneal dialysis (PD), and 77 (65%) with haemodialysis (HD). Significant predictors for treatment with PD were younger age at dialysis start (OR 0.85 per year increase [95%CI 0.72–1.00]) and PD use before kidney transplantation (OR 8.20 [95%CI 1.82–37.01]). Patients entering DAGF in more recent eras (OR 0.87 per year increase [95%CI 0.80–0.94]) and with more than one dialysis modality before kidney transplantation (OR 0.56 for being treated with PD [0.12–2.59]) were more likely to be initiated on HD. As compared to patients on HD, those treated with PD exhibited increased but non-significant mortality risk (HR 2.15 [95%CI 0.54–8.6]; p = 0.28) and higher prevalence of dialysis-related complications during DAGF (p = 0.002) Conclusions Patients entering DAGF in more recent years are more likely to be initiated on HD. In this specific population of children, use of PD seems associated with a more complicated course. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information

scholarly journals Characteristics of Circulating Donor Human Leukocyte Antigen-specific Immunoglobulin G Antibodies Predictive of Acute Antibody-mediated Rejection and Kidney Allograft Failure

2015 ◽  
Vol 99 (6) ◽  
pp. 1156-1164 ◽  
Author(s):  
Dinesh Kannabhiran ◽  
John Lee ◽  
Joseph E. Schwartz ◽  
Rex Friedlander ◽  
Meredith Aull ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Immunoglobulin G ◽  
Human Leukocyte ◽  
Kidney Allograft ◽  
Leukocyte Antigen ◽  
Antibody Mediated Rejection ◽  
Allograft Failure ◽  
Specific Immunoglobulin

600 Association of early kidney allograft failure with preformed IgA antibodies to β2-glycoprotein I

2016 ◽  
Vol 15 (3) ◽  
pp. e600
Author(s):  
F. De La Rosa Kehrmann ◽  
L. García González ◽  
J.A. Martínez-Flores ◽  
J.M. Duarte Ojeda ◽  
M. Pamplona Casamayor ◽  
...  
Keyword(s):  
Kidney Allograft ◽  
Glycoprotein I ◽  
Allograft Failure ◽  
Iga Antibodies

scholarly journals Kidney allograft failure due to acute phosphate nephropathy associated with severe secondary hyperparathyroidism

2011 ◽  
Vol 4 (5) ◽  
pp. 324-326
Author(s):  
P.-N. Wong ◽  
A. N. H. Chan ◽  
K.-Y. Lo ◽  
Y.-Y. Wong ◽  
S.-K. Mak ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Kidney Allograft ◽  
Allograft Failure ◽  
Phosphate Nephropathy

Returning to haemodialysis after kidney allograft failure: a survival study with propensity score matching

2018 ◽  
Vol 34 (4) ◽  
pp. 667-672 ◽  
Author(s):  
Javier Varas ◽  
María José Pérez-Sáez ◽  
Rosa Ramos ◽  
Jose Ignacio Merello ◽  
Angel Luis M de Francisco ◽  
...  
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Kidney Allograft ◽  
Survival Study ◽  
Allograft Failure

INFLAMMATION IN AREAS OF TUBULAR ATROPHY (IATR) PREDICTS KIDNEY ALLOGRAFT FAILURE

2010 ◽  
Vol 90 ◽  
pp. 384
Author(s):  
R. B. Mannon ◽  
A. J. Matas ◽  
R. Leduc ◽  
J. M. Cecka ◽  
F. Cosio ◽  
...  
Keyword(s):  
Tubular Atrophy ◽  
Kidney Allograft ◽  
Allograft Failure

scholarly journals Pretransplantation Erythropoiesis-Stimulating Agent Hyporesponsiveness Is Associated with Increased Kidney Allograft Failure and Mortality

2013 ◽  
Vol 96 (9) ◽  
pp. 807-813 ◽  
Author(s):  
Nadiesda A. Costa ◽  
Abhijit V. Kshirsagar ◽  
Lily Wang ◽  
Randal K. Detwiler ◽  
M. Alan Brookhart
Keyword(s):  
Kidney Allograft ◽  
Allograft Failure

A Single-Center Assessment of Delayed Graft Function in Recipients of Simultaneous Liver and Kidney Transplant

2020 ◽  
Vol 30 (4) ◽  
pp. 342-348
Author(s):  
Fahad Aziz ◽  
Ali Gardezi ◽  
Brenda Muth ◽  
Justin Blazel ◽  
Neetika Garg ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Kidney Graft ◽  
Kidney Allograft ◽  
Risk Of Death ◽  
Kidney Recipients ◽  
Allograft Failure ◽  
Liver And Kidney ◽  
Multiple Variables

Background: The effects of delayed graft function on long-term kidney allograft outcomes are poorly defined among simultaneous liver and kidney transplant recipients. Methods: We analyzed data of all simultaneous liver and kidney recipients transplanted at the University of Wisconsin between 2010 and 2017. Risk factors for the development of delayed graft function, kidney graft failure, and patient mortality were outcomes of interest. Results: There were a total of 60 simultaneous liver and kidney recipients; 28 (47%) had delayed graft function. After adjustment for multiple variables, we found that pretransplant dialysis >6 weeks (hazard ratio [HR] = 5.6, 95% CI: 1.23-25.59, P = .02), pretransplant albumin <3 g/dL (HR = 5.75, 95% CI: 1.76-16.94, P = .003), and presence of pretransplant diabetes (HR = 2.5, 95% CI: 0.97-4.77, P = .05) were significantly associated with delayed graft function. Multivariate analysis showed that pretransplant albumin <3 (HR = 4.86, 95% CI: 1.07-22.02, P = .02) was associated with a higher risk of all-cause kidney allograft failure, whereas the duration of delayed graft function (HR = 1.07 per day, 95% CI: 1.01-1.14, P = .01) was associated with a higher risk of death-censored kidney allograft failure. The presence of delayed graft function was not associated with all-cause or death-censored kidney or liver allograft failure. Similarly, the presence of delayed graft function was not associated with patient mortality. Conclusion: The incidence of delayed graft function was high in simultaneous liver and kidney recipients. However, with appropriate management, delayed graft function may not have a negative impact on patient or kidney allograft survival.

scholarly journals Deceased-donor acute kidney injury is not associated with kidney allograft failure

2019 ◽  
Vol 95 (1) ◽  
pp. 199-209 ◽  
Author(s):  
Isaac E. Hall ◽  
Enver Akalin ◽  
Jonathan S. Bromberg ◽  
Mona D. Doshi ◽  
Tom Greene ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Deceased Donor ◽  
Kidney Allograft ◽  
Allograft Failure

scholarly journals The Causes of Kidney Allograft Failure

2020 ◽  
Vol 104 (2) ◽  
pp. e46-e56 ◽  
Author(s):  
Elisabet Van Loon ◽  
Jelle Bernards ◽  
Amaryllis H. Van Craenenbroeck ◽  
Maarten Naesens
Keyword(s):  
Kidney Allograft ◽  
Allograft Failure
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