Interaction Between Ischemic Time and Donor Age Under the New Donor Heart Allocation System: Effect on Post‐Transplant Survival

2022 ◽  
Author(s):  
Taylor Nordan ◽  
Shant H. Mahrokhian ◽  
Caroline J. Liang ◽  
Jamel P. Ortoleva ◽  
Andre C. Critsinelis ◽  
...  
Keyword(s):  
Donor Heart ◽  
Donor Age ◽  
System Effect ◽  
Ischemic Time ◽  
Transplant Survival ◽  
Allocation System ◽  
Post Transplant

Impact of the 2018 Donor Heart Allocation System on Post Transplant Morbidity and Mortality

2020 ◽  
Vol 26 (10) ◽  
pp. S149
Author(s):  
Lily K. Stern ◽  
Angela Velleca ◽  
Keith Nishihara ◽  
Adriana Shen ◽  
Michael Zaliznyak ◽  
...  
Keyword(s):  
Morbidity And Mortality ◽  
Donor Heart ◽  
Allocation System ◽  
Post Transplant

scholarly journals Impact of the new MELD‐based allocation system on waiting list and post‐transplant survival—a cohort analysis using the French national CRISTAL database

2019 ◽  
Vol 32 (10) ◽  
pp. 1061-1073 ◽  
Author(s):  
Carine Jasseron ◽  
Claire Francoz ◽  
Corinne Antoine ◽  
Camille Legeai ◽  
François Durand ◽  
...  
Keyword(s):  
Cohort Analysis ◽  
Waiting List ◽  
Transplant Survival ◽  
Allocation System ◽  
Post Transplant

Evaluation of the Effect of the New French Allocation System on Waitlist and Post-Transplant Survival

2020 ◽  
Vol 39 (4) ◽  
pp. S269
Author(s):  
C. Jasseron ◽  
B. Audry ◽  
C. Legeai ◽  
C. Cantrelle ◽  
C. Jacquelinet ◽  
...  
Keyword(s):  
Transplant Survival ◽  
Allocation System ◽  
Post Transplant

An updated estimate of post‐transplant survival after implementation of the new donor heart allocation policy

2021 ◽  
Author(s):  
Kevin A. Lazenby ◽  
Nikhil Narang ◽  
Kenley M. Pelzer ◽  
Gege Ran ◽  
William F. Parker
Keyword(s):  
Donor Heart ◽  
Allocation Policy ◽  
Transplant Survival ◽  
Post Transplant

Ischemic Time Greater Than Four Hours is Associated with Increased Mortality among Candidates Listed and Transplanted under the New Donor Heart Allocation System

2021 ◽  
Vol 40 (4) ◽  
pp. S267-S268
Author(s):  
T. Nordan ◽  
A.C. Critsinelis ◽  
C.E. Hironaka ◽  
Y. Zhan ◽  
F.Y. Chen ◽  
...  
Keyword(s):  
Donor Heart ◽  
Ischemic Time ◽  
Allocation System

scholarly journals Systematic Assessment of Safety Threshold for Donor Age in Cadaveric Liver Transplantation

2021 ◽  
Vol 8 ◽  
Author(s):  
Wenchao Wang ◽  
Zhengtao Liu ◽  
Junjie Qian ◽  
Jun Xu ◽  
Shuping Que ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Dependent Manner ◽  
Donor Age ◽  
Ischemic Time ◽  
Quantitative Evidence ◽  
Systematic Assessment ◽  
Post Transplant ◽  
Transplant Outcomes ◽  
Cold Ischemic Time ◽  
Age Related

Background: Donor age affects allograft quality and the prognosis of recipients after liver transplantation (LT). Clinicians have assessed the quality of grafts from older donors based on their appearance and texture, with no reliable quantitative evidence. Our study aimed to assess the quantitative impact of donor age on post-transplant outcomes and its safety threshold for LT, based on the published literature.Methods: Relevant studies were retrieved from the Embase, PubMed, and ISI Web of Science databases. Pooled dichotomous relative risks (RRs) were calculated using metan. Continuous RRs were calculated using a two-stage random-effects model.Results: Eleven studies including 30,691 LT cases were included for further analysis. For categorical comparison, the RR of death within the first post-transplant year was significantly higher among patients who received grafts from older donors. Similarly, the RR of graft failure (GF) was increased within the 3 years after transplantation. For continuous comparison, advanced donor age affected transplant outcomes in a linear manner (P > 0.05). A 10-year increment in donor age was associated with RRs 1.10, 1.12, 1.15, 1.10, and 1.08 for 90-day, 180-day, 1-year, 3-year, and 5-year patient mortality and 1.08, 1.06, 1.10, 1.11, and 1.12, for 90-day, 180-day, 1-year, 2-year, and 3-year GF, respectively (all P < 0.05). A spline model showed that transplants using grafts from donors <43 years old were not associated with age-related risks (P > 0.05). The risk of GF was increased in subgroups with fewer LT cases, longer cold ischemic time, fewer male donors, and recipients with viral hepatitis (P < 0.05).Conclusion: Donor age might affect post-LT outcomes in a dose-dependent manner. The safety threshold for donor age in terms of GF should be lowered to 43 years as an early warning for the guarantee of satisfactory outcomes. Clinicians should weigh the benefits against the risks carefully for patients receiving grafts from older donors. Further studies are warranted to investigate the mechanisms responsible for the relationship between donor age and graft quality.

87: Influence of the New Heart Allocation System on Pediatric Waitlist and Post-Transplant Survival

2010 ◽  
Vol 29 (2) ◽  
pp. S34-S35
Author(s):  
A. Iribarne ◽  
M.J. Russo ◽  
R.R. Davies ◽  
H. Takayama ◽  
J.M. Quaegebeur ◽  
...  
Keyword(s):  
Transplant Survival ◽  
Allocation System ◽  
Post Transplant
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