An updated estimate of post‐transplant survival after implementation of the new donor heart allocation policy

2021 ◽  
Author(s):  
Kevin A. Lazenby ◽  
Nikhil Narang ◽  
Kenley M. Pelzer ◽  
Gege Ran ◽  
William F. Parker
Keyword(s):  
Donor Heart ◽  
Allocation Policy ◽  
Transplant Survival ◽  
Post Transplant

Interaction Between Ischemic Time and Donor Age Under the New Donor Heart Allocation System: Effect on Post‐Transplant Survival

2022 ◽  
Author(s):  
Taylor Nordan ◽  
Shant H. Mahrokhian ◽  
Caroline J. Liang ◽  
Jamel P. Ortoleva ◽  
Andre C. Critsinelis ◽  
...  
Keyword(s):  
Donor Heart ◽  
Donor Age ◽  
System Effect ◽  
Ischemic Time ◽  
Transplant Survival ◽  
Allocation System ◽  
Post Transplant

scholarly journals Comparison of Six-Month Post-Transplant Survival before and after Implementation of the 2018 UNOS Allocation Policy Change

2021 ◽  
Vol 40 (4) ◽  
pp. S249
Author(s):  
M.M. Saffarian ◽  
A. Sharma ◽  
S. Hashmi ◽  
J.P. Li ◽  
S.R. Miller ◽  
...  
Keyword(s):  
Policy Change ◽  
Allocation Policy ◽  
Transplant Survival ◽  
Post Transplant ◽  
Before And After

Abstract 15953: Impact of Citizenship on Heart Transplantation Outcomes in the United States

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Allison P Levin ◽  
Thomas C Hanff ◽  
Robert S Zhang ◽  
Rhondalyn C McLean ◽  
Joyce W Wald ◽  
...  
Keyword(s):  
United States ◽  
Heart Transplant ◽  
Transplant Rejection ◽  
The United States ◽  
Heart Transplants ◽  
Allocation Policy ◽  
Transplant Survival ◽  
Post Transplant ◽  
Significant Difference ◽  
Face Complex

Background: Non-citizens of the United States face complex social and economic issues, which may impact their post-transplant outcomes compared to US citizens. To this end, we utilized the United Network for Organ Sharing (UNOS) database to examine post-heart transplant (OHT) outcomes, stratified by citizenship status. Methods: UNOS was queried to identify OHT recipients from 03/01/12 (start of new schema for citizenship categorization) through 10/18/18 (start of new heart allocation algorithm). Groups for analysis, were as follows: US Citizen, Non-US Citizen/Resident (NC-R) and Non-US Citizen/Non-US Resident (NC-NR). Post-transplant survival and rate of post-transplant rejection were assessed via Kaplan-Meier analysis and tests of proportions. Results: Of the 16,211 OHT recipients identified, 15,677 (96.7%) were US citizens and 534 (3.3%) were Non-Citizens. Among Non-Citizens, 430 were NC-R and 104 were NC-NR, representing 2.7% and 0.6% of the total transplants. Notably, NC-NR were younger than either Citizens or NC-R, and had the shortest median time from listing to transplant (NC-R 80 days vs. Citizens 107 days vs. NC-NR 76 days, p=0.001). The proportion of transplants received by non-citizens varied widely by region, ranging from 0.59% in region 8 (6/1018) to 8.31% (84/1011) in region 9. There was no significant difference in post-transplant survival estimates in citizens vs. non-citizens (logrank p = 0.542), nor in the proportion of patients treated for rejection by one year (15.0% vs. 16.1%, p= 0.504) Conclusion: Non-US Citizens receive three percent of heart transplants performed in the US each year. Post-heart transplant survival and rate of rejection are similar in US citizens and non-citizens. These data may be relevant in the context of evolving UNOS policies. Additional studies are needed are to further inform organ allocation policy.

scholarly journals Waitlist mortality and post-transplant survival in patients with cholestatic liver disease – Impact of changes in allocation policy

HPB ◽  
2018 ◽  
Vol 20 (10) ◽  
pp. 916-924 ◽  
Author(s):  
Katharina Staufer ◽  
Danijel Kivaranovic ◽  
Susanne Rasoul-Rockenschaub ◽  
Thomas Soliman ◽  
Michael Trauner ◽  
...  
Keyword(s):  
Liver Disease ◽  
Cholestatic Liver Disease ◽  
Allocation Policy ◽  
Transplant Survival ◽  
Post Transplant ◽  
Disease Impact ◽  
Waitlist Mortality

Clinical stabilization of ACLF patients before orthotopic liver transplantation predicts post-transplant survival

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
P Huebener ◽  
M Sterneck ◽  
K Bangert ◽  
A Lohse ◽  
S Kluge ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Transplant Survival ◽  
Post Transplant ◽  
Clinical Stabilization

scholarly journals Suppressing Pyroptosis Augments Post-Transplant Survival of Stem Cells and Cardiac Function Following Ischemic Injury

2021 ◽  
Vol 22 (15) ◽  
pp. 7946
Author(s):  
Chang Youn Lee ◽  
Seahyoung Lee ◽  
Seongtae Jeong ◽  
Jiyun Lee ◽  
Hyang-Hee Seo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Stem Cell ◽  
Cardiac Fibrosis ◽  
Ischemia Reperfusion ◽  
Cardiac Cells ◽  
Transplant Survival ◽  
Post Transplant ◽  
Heart Functions ◽  
Cell Death Mechanisms

The acute demise of stem cells following transplantation significantly compromises the efficacy of stem cell-based cell therapeutics for infarcted hearts. As the stem cells transplanted into the damaged heart are readily exposed to the hostile environment, it can be assumed that the acute death of the transplanted stem cells is also inflicted by the same environmental cues that caused massive death of the host cardiac cells. Pyroptosis, a highly inflammatory form of programmed cell death, has been added to the list of important cell death mechanisms in the damaged heart. However, unlike the well-established cell death mechanisms such as necrosis or apoptosis, the exact role and significance of pyroptosis in the acute death of transplanted stem cells have not been explored in depth. In the present study, we found that M1 macrophages mediate the pyroptosis in the ischemia/reperfusion (I/R) injured hearts and identified miRNA-762 as an important regulator of interleukin 1b production and subsequent pyroptosis. Delivery of exogenous miRNA-762 prior to transplantation significantly increased the post-transplant survival of stem cells and also significantly ameliorated cardiac fibrosis and heart functions following I/R injury. Our data strongly suggest that suppressing pyroptosis can be an effective adjuvant strategy to enhance the efficacy of stem cell-based therapeutics for diseased hearts.

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