scholarly journals Pharmacogenomics of celiprolol – evidence for a role of P‐glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics

2021 ◽  
Author(s):  
Päivi Hirvensalo ◽  
Aleksi Tornio ◽  
Tuija Tapaninen ◽  
Maria Paile‐Hyvärinen ◽  
Mikko Neuvonen ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporting Polypeptide ◽  
P Glycoprotein

scholarly journals Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

2011 ◽  
Vol 25 (1) ◽  
pp. 1-14 ◽  
Author(s):  
W. Edward Visser ◽  
Edith C. H. Friesema ◽  
Theo J. Visser
Keyword(s):  
Thyroid Hormone ◽  
Organic Anion ◽  
Psychomotor Retardation ◽  
Cellular Level ◽  
Monocarboxylate Transporter ◽  
Causative Role ◽  
Organic Anion Transporting Polypeptide ◽  
Neurological Abnormalities ◽  
Knockout Animals

The effects of thyroid hormone (TH) on development and metabolism are exerted at the cellular level. Metabolism and action of TH take place intracellularly, which require transport of the hormone across the plasma membrane. This process is mediated by TH transporter proteins. Many TH transporters have been identified at the molecular level, although a few are classified as specific TH transporters, including monocarboxylate transporter (MCT)8, MCT10, and organic anion-transporting polypeptide 1C1. The importance of TH transporters for physiology has been illustrated dramatically by the causative role of MCT8 mutations in males with psychomotor retardation and abnormal serum TH concentrations. Although Mct8 knockout animals have provided insight in the mechanisms underlying parts of the endocrine phenotype, they lack obvious neurological abnormalities. Thus, the pathogenesis of the neurological abnormalities in males with MCT8 mutations is not fully understood. The prospects of identifying other transporters and transporter-based syndromes promise an exciting future in the TH transporter field.

Concentration-Dependent Effect of Naringin on Intestinal Absorption of β1-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)

2008 ◽  
Vol 26 (3) ◽  
pp. 560-567 ◽  
Author(s):  
Yoshiyuki Shirasaka ◽  
Yan Li ◽  
Yuta Shibue ◽  
Erika Kuraoka ◽  
Hildegard Spahn-Langguth ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Organic Anion ◽  
Dependent Effect ◽  
Organic Anion Transporting Polypeptide ◽  
Adrenoceptor Antagonist ◽  
P Glycoprotein

The Role of P-Glycoprotein and Canalicular Multispecific Organic Anion Transporter in the Hepatobiliary Excretion of Drugs

1998 ◽  
Vol 87 (9) ◽  
pp. 1025-1040 ◽  
Author(s):  
Hiroyuki Kusuhara ◽  
Hiroshi Suzuki ◽  
Yuichi Sugiyama
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
P Glycoprotein ◽  
Anion Transporter

scholarly journals P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions

2014 ◽  
pp. 475 ◽  
Author(s):  
Xin He ◽  
Sheng Liang ◽  
Fengchun Deng ◽  
Haiyan Xing ◽  
He Wen ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Organic Anion ◽  
Organic Anion Transporting Polypeptide ◽  
P Glycoprotein

scholarly journals Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1

2009 ◽  
Vol 18 (11) ◽  
pp. 2298-2306 ◽  
Author(s):  
Chunshan Gui ◽  
Bruno Hagenbuch
Keyword(s):  
Transmembrane Domain ◽  
Organic Anion ◽  
Organic Anion Transporting Polypeptide

scholarly journals Important role of organic anion transporting polypeptide in disposition of flavonoid

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO2-14-16
Author(s):  
Jianqing Ruan ◽  
Hui Zhi ◽  
Linghua Kong
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporting Polypeptide

Relationship between biliary lipid and protoporphyrin secretion; potential role of mdr2 P-glycoprotein in hepatobiliary organic anion transport

1996 ◽  
Vol 24 (3) ◽  
pp. 343-352 ◽  
Author(s):  
Gerard J.J. Beukeveld ◽  
Gerda In't Veld ◽  
Rick Havinga ◽  
Albert K. Groen ◽  
Bert G. Wolthers ◽  
...  
Keyword(s):  
Potential Role ◽  
Organic Anion ◽  
Anion Transport ◽  
Biliary Lipid ◽  
Organic Anion Transport ◽  
P Glycoprotein

scholarly journals Potential role of organic anion transporting polypeptide 1B1 (OATP1B1) in the selective hepatic uptake of hematoporphyrin monomethyl ether isomers

2014 ◽  
Vol 36 (2) ◽  
pp. 268-280 ◽  
Author(s):  
Xiu-li Li ◽  
Zi-tao Guo ◽  
Ye-dong Wang ◽  
Xiao-yan Chen ◽  
Jia Liu ◽  
...  
Keyword(s):  
Potential Role ◽  
Organic Anion ◽  
Monomethyl Ether ◽  
Hepatic Uptake ◽  
Organic Anion Transporting Polypeptide ◽  
Hematoporphyrin Monomethyl Ether
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