Diffuse cutaneous bullous mastocytosis with IgM deposits at dermo-epidermal junction

2015 ◽  
Vol 43 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Kinga Cristina Slavescu ◽  
Roxana Chiorean ◽  
Sorina Danescu ◽  
Madalina Bota ◽  
Liliana Rogojan ◽  
...  
Keyword(s):  
Bullous Mastocytosis ◽  
Igm Deposits

Bullous mastocytosis

1970 ◽  
Vol 101 (5) ◽  
pp. 547-564 ◽  
Author(s):  
M. Orkin
Keyword(s):  
Bullous Mastocytosis

A rare case of bullous mastocytosis in a child associated with bathing trunk nevus

2014 ◽  
Vol 53 (6) ◽  
pp. 761-763 ◽  
Author(s):  
Rajesh Verma ◽  
Biju Vasudevan ◽  
Pragasam Vijendran ◽  
Debdeep Mitra
Keyword(s):  
Rare Case ◽  
Bullous Mastocytosis

scholarly journals Glomerulonephritis in schistosomiasis with mesangial IgM deposits

1981 ◽  
Vol 76 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Ageu Godoy Magalhães Filho ◽  
Antônio Victoriano Barbosa ◽  
Teresa Cristina Ferreira
Keyword(s):  
Cell Proliferation ◽  
Light Microscopy ◽  
Immunofluorescence Microscopy ◽  
The Other ◽  
Proliferative Glomerulonephritis ◽  
Mesangial Proliferative Glomerulonephritis ◽  
Normal Pattern ◽  
Glomerular Lesions ◽  
Capillary Walls ◽  
Igm Deposits

Twenty one cases of hepatoesplenic schistosomiasis patients without clinical and laboratory evidence of renal disease, were studied by surgical biopsies using light microscopy and immunofluorescence. The cases were classified histologically as: normal pattern (6 cases); minimal changes (6 cases); and mesangial proliferative glomerulonephritis (9 cases). By the immunofluorescence microscopy using anti IgM, IgG, IgA and C3, the predominant finding in all biopsies, except the normal cases, was granular deposits of IgM in the mesangium along with C3. On the other hand, IgG was present in all cases including normal biopsies along the capillary walls. However IgG was also present in the mesangium only in cases with glomerular lesions. This finding may well be similar to that recently described as IgM mesangial nephropathy. According to our cases a mesangial proliferative glomerulonephritis, characterized by segmental cell proliferation and deposition of IgM in the mesangium, is probably the entity found in the early stages of mansonic schistosomiasis.

scholarly journals Immunofluorescent microscopy in patients with IgA nephropathy

2019 ◽  
Vol 16 (3) ◽  
pp. 317-323
Author(s):  
K. S. Komissarov ◽  
M. V. Dmitrieva ◽  
T. A. Letkovskaya ◽  
V. S. Pilotovich ◽  
O. V. Krasko
Keyword(s):  
Gradual Increase ◽  
Pathological Findings ◽  
Positive Relation ◽  
Oxford Classification ◽  
Exclusion Criteria ◽  
Negative Relation ◽  
Endothelial Proliferation ◽  
The Oxford Classification ◽  
Acute Reaction ◽  
Igm Deposits

The aim of the study was to evaluate relations between the deposition of IgA, IgG, IgM, C3, C1q and baseline clinical features and pathological findings.According to exclusion criteria, 72 patients with diagnosed primary IgAN who were biopsied from 2015 to 2017 in the district of the Minsk city, Belarus were included for retrospective analysis. All biopsy had to be reviewed according to the Oxford classification (MEST-C). We examined the immunofluorescence staining with antibodies against IgG, IgA, IgM, C3, C1q.Mean age was 32 (26; 42.5) years, 72.2% was men, 48.6% of the patients had arterial hypertension. Median of proteinuria was 870 (355; 1420) mg/day, 8.4% of the patients had isolated hematuria, serum creatinine – 104 (89; 126.5) µmol/l.The patients with 3+ IgA deposits showed a significantly higher percentage of crescents (C1-2) than those with 2+ IgA deposits (p = 0.028). The presence of C3 deposits showed a gradual increase in the percentage of endothelial proliferation (E1) (p = 0.007). The degree of IgA deposits showed a significant negative relation to the IgM deposits (p = 0.01) and a positive relation to the C3 deposits (p = 0.001).We found that the intensity of IgA and C3 deposits is associated with histopathology markers of the acute reaction (C1-2 and E1) according to the Oxford classification. At the same time, the appearance of the IgM deposits testifies the acute phase of the disease as well as the advanced sclerotic stage in some patients.

scholarly journals Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma

2019 ◽  
Vol 9 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Taisuke Irifuku ◽  
Ayaka Satoh ◽  
Hiroki Tani ◽  
Kouichi Mandai ◽  
Takao Masaki
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Function ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tubulointerstitial Nephritis ◽  
Basement Membranes ◽  
High Dose ◽  
Close Monitoring ◽  
Acute Tubulointerstitial Nephritis ◽  
Igm Deposits

Abstract Nivolumab is an anti-programmed cell death-1 antibody that is utilized as an immune checkpoint inhibitor for several malignancies. However, this agent is associated with immune-related adverse events (irAEs), mainly in the spectrum of autoimmune disease including interstitial pneumonia, colitis, type 1 diabetes, and renal impairment. We herein present the case of a 59-year-old man with renal cell carcinoma who developed worsening renal function approximately 4 months after initiation of nivolumab. Urinalysis showed proteinuria and microscopic hematuria along with increase levels of N-acetyl-β-d-glucosaminidase. Renal biopsy revealed acute tubulointerstitial nephritis and thickening of the glomerular basement membranes. Immunofluorescence showed granular IgM deposits in capillary loops. We initiated high-dose prednisolone therapy with nivolumab, which improved renal function and achieved complete remission of proteinuria. Although renal irAEs are considered to be rare and glomerulonephropathy is not typical presentation, physicians need the close monitoring of renal function and urinalysis in patients under immunotherapy with this agents. In addition, our case provides a possible link between nivolumab and immune-mediated glomerulonephropathy.

P085 A case of extremely widespread and severe bullous mastocytosis

1997 ◽  
Vol 9 ◽  
pp. S173 ◽  
Author(s):  
N MARTINOVIC ◽  
S VESIC ◽  
K MARTINOVIC
Keyword(s):  
Bullous Mastocytosis

scholarly journals B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions

2011 ◽  
Vol 109 (8) ◽  
pp. 830-840 ◽  
Author(s):  
Tin Kyaw ◽  
Christopher Tay ◽  
Surendran Krishnamurthi ◽  
Peter Kanellakis ◽  
Alex Agrotis ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Atherosclerotic Lesions ◽  
Natural Igm ◽  
Igm Deposits

Recurring Staphylococcal Scalded Skin Syndrome‐like Bullous Mastocytosis: The Utility of Cytodiagnosis and the Rapid Regression with Steroids

2002 ◽  
Vol 19 (3) ◽  
pp. 220-223 ◽  
Author(s):  
Cristina Has ◽  
Laurent Misery ◽  
Louis David ◽  
Frédéric Cambazard
Keyword(s):  
Staphylococcal Scalded Skin Syndrome ◽  
Bullous Mastocytosis ◽  
Rapid Regression

The Significance of Linear IgM Deposits in the Basement Membrane Zone-Reply

1992 ◽  
Vol 128 (12) ◽  
pp. 1653
Author(s):  
CDR Mark W. Cobb
Keyword(s):  
Basement Membrane ◽  
Basement Membrane Zone ◽  
Igm Deposits
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