Folliculotropic mycosis fungoides presenting with a solitary lesion: Clinicopathological features and long-term follow-up data in a series of 9 cases

Background: Granulomatous mastitis also known as granulomatous inflammatory lesionsof the breast can be divided into idiopathic granulomatous mastitis and granulomatousmastitis occurring as a rare secondary complication of a great variety of other conditions.Treatment is radically different for idiopathic granulomatous mastitis and other granulomatouslesions of the breast, the precise diagnosis is therefore very important. Objectives: The purpose of this study was to find the clinicopathological features ofidiopathic granulomatous mastitis, as well as the authors' experience with surgicaltreatment of these patients. Methods and Materials: A hospital based retrospective study done with twenty diagnosedpatients of idiopathic granulomatous mastitis enrolled from department of surgery, Ad-dinwomen's.medical college hospital, Dhaka in the period between July 2012- July 2015. Results: Mean age of presentation was 38.1 years. All patients had a history of childbirthand breastfeeding. Sixteen (80%) patients were premenopausal. The main clinical featurewas a mass in the breast in all patients and clinical findings suggesting an infection accompaniedthe mass in seven patients (35%). Surgery was the definitive procedure in allpatients. Wide local excision done in all patients. None of the patients received steroids.Median follow-up time was 12 months. During follow-up, two patients (10%) presented withrecurrence. All patients with recurrence had a mass in their breasts on the same side ofprevious disease. Conclusion: Increased recognition of this disease will improve its understanding andmanagement. Long-term follow-up is necessary. Journal of Surgical Sciences (2016) Vol. 20 (2) :51-54

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Long-term follow-up and secondary malignancy in mycosis fungoides patients treated by electron beam irradiation.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e18511 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e18511-e18511

Author(s):

Miroslav Lutsyk ◽

Orit Kaidar-Person ◽

Micha Bar-Hanna ◽

Yoram Cohen ◽

Abraham Kuten

Keyword(s):

Electron Beam ◽

Mycosis Fungoides ◽

Electron Beam Irradiation ◽

Secondary Malignancy ◽

Secondary Malignancies ◽

Beam Irradiation ◽

Photon Irradiation ◽

Long Term Follow Up

e18511 Background: Mycosis fungoides (MF) and Sezary's syndrome are the most common subgroup of cutaneous T-cell lymphoma. Total or partial skin electron beam irradiation (TSEI, PSEI) is an accepted treatment option in cases of disease that is limited to the skin and as palliative treatment in advanced disease. Consequently, long term follow-up of these patients and detection of secondary malignancies after TSEI/PSEI is crucial. The aim of this study was to summarize long term follow-up of MF patients treated by TSEI or PSEI and to evaluate the rates of secondary malignancies. Methods: A retrospective review of the medical charts of all consecutive patients diagnosed with MF who was treated from January 1960 to June 2010 at our hospital was conducted. Data collected included demographics, date of diagnosis, staging, treatment, and secondary malignancies. Results: One hundred ninety six patients were included (132 M, 64 F). The median age at diagnosis was 67.3 years. The mean follow-up was 109.4±89.4 months (range 1-566). One hundred patients received TSEI, 45 patients received PSEI, and one patient was treated by low dose total body photon irradiation combined with TSEI. Fifty patients (50/196, 25.5%) developed a second malignancy, 16 patients (16/196, 8%) had a third malignancy, and 4 (2%) patients developed a fourth malignancy. Conclusions: MF is associated with development of sequential malignancies. The contribution of TSEI or PSEI to the development of secondary malignancies is yet to be determined. Long term follow-up in this group of patients is essential.

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