Melanoma Mimicking Atypical Fibroxanthoma: Report of an Unusual Case

2021 ◽

pp. 106689692110447

Author(s):

Juan J. Ríos-Martín ◽

Manuel Pérez-Pérez ◽

Sebastián Umbría-Jiménez ◽

David Moreno-Ramírez ◽

Ana Vallejo-Benítez

Keyword(s):

Cyclin D1 ◽

Copy Number ◽

Poor Prognosis ◽

Unusual Case ◽

Prognostic Significance ◽

Mutation Status ◽

Atypical Fibroxanthoma ◽

Desmoplastic Melanoma ◽

Aggressive Tumor

Numerous cells with very large and irregular nuclei (“monster” cells) have not hitherto been reported in desmoplastic melanoma (DM). Their prognostic significance in melanomas is a matter of debate, although some authors have associated them with more aggressive tumor behavior. We report a mixed DM on the scalp of an 88-year-old woman imitating an atypical fibroxanthoma. Tumor cells stained positive for SOX10, S100, and cyclin D1; BRAF mutation status was negative, and fluorescence in situ hybridization analysis showed copy number gains in 11q13 (cyclin D1) and 6p25 (RREB1), and loss in 6q23 (MYB). Cyclin D1 amplification is associated with poor prognosis in melanoma.

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Clear-cell atypical fibroxanthoma: An unusual case in an unusual place

Journal of Cutaneous Pathology ◽

10.1111/cup.13015 ◽

2017 ◽

Vol 44 (11) ◽

pp. 951-953

Author(s):

Zachary Goldstein ◽

George Sarantopoulos ◽

Chandra Smart

Keyword(s):

Unusual Case ◽

Clear Cell ◽

Atypical Fibroxanthoma

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Atypical fibroxanthoma in a young woman: An unusual case presentation

Plastic Surgery ◽

10.4172/plastic-surgery.1000517 ◽

2007 ◽

Vol 15 (3) ◽

Cited By ~ 1

Author(s):

Mark M Melendez ◽

Xiaoti Xu ◽

Steve A McClain

Keyword(s):

Young Woman ◽

Unusual Case ◽

Case Presentation ◽

Atypical Fibroxanthoma

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An Unusual Case of Pinna Squamous Cell Carcinoma Arising Shortly after Resection of Atypical Fibroxanthoma

Case Reports in Otolaryngology ◽

10.1155/2018/6092169 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7

Author(s):

Eugene Omakobia ◽

Ahmad Orabi ◽

Richard Knights

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Unusual Case ◽

English Literature ◽

Sun Exposure ◽

Scar Tissue ◽

Unique Case ◽

Atypical Fibroxanthoma ◽

Common Cancer

Objective. To report a unique case of pinna squamous cell carcinoma (SCC) arising shortly after resection of atypical fibroxanthoma (AFX) at the same site. Case report. An 81-year-old gentleman presented with a nodular right pinna lesion. This was excised, and histology confirmed AFX. Ten weeks later, an ulcerative lesion appeared at the resection site. This was confirmed to be SCC. Comparative analysis revealed no morphological resemblance between the initial AFX and new SCC lesion, and there was no evidence of initial misdiagnosis. Conclusion. SCC is the most common cancer involving the pinna. Whilst prolonged sun exposure is an important risk factor for SCC, chronic inflammation and wounds are other potential sources. We postulate whether SCC could have arisen from the previous scar tissue in a manner similar to Marjolin’s ulcer. This would be a highly unusual finding in the pinna and to our knowledge unprecedented in the English literature.

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