Pulsed dye laser (FPDL) treatment of a plantar verruca vulgaris and in vivo monitoring of therapy with confocal laser scan microscopy (CLSM)

✓ Laser energy of 480 nm was applied in 1-µsec pulses varying between 2.2 and 10 mJ to in vitro and in vivo models of cerebral vasospasm. First, the pulsed-dye laser was applied intravascularly via a 320-µm fiber to basilar artery segments from six dogs. The segments were mounted in a vessel-perfusion apparatus and constricted to, on average, 70% of resting diameter by superfusion with dog hemolysate. Immediate increase in basilar artery diameter occurred to a mean of 83% of control. In a second model, the basilar artery was exposed transclivally in the rabbit. In three normal animals, superfusion of the artery with rabbit hemolysate resulted in a reduction of mean vessel diameter to 81% of control. Following extravascular application of the laser, vessels returned to an average of 106% of the resting state. In six rabbits, the basilar artery was constricted by two intracisternal injections of autologous blood, 3 days apart. Two to 4 days after the second injection, the basilar artery was exposed. Extravascular laser treatment from a quartz fiber placed perpendicular to the vessel adventitia resulted in an immediate 53% average increase in caliber to an estimated 107% of control. No reconstriction was observed over a period of up to 5 hours. Morphologically, damage to the arterial wall was slight. This preliminary investigation suggests that the 1-µsec pulsed-dye laser may be of benefit in the treatment of cerebral vasospasm.

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In vivo quantification of the structural abnormalities in psoriatic microvessels before and after pulsed dye laser treatment

British Journal of Dermatology ◽

10.1111/j.1365-2133.2005.06435.x ◽

2005 ◽

Vol 152 (3) ◽

pp. 505-511 ◽

Cited By ~ 37

Author(s):

S. Hern ◽

A.W.B. Stanton ◽

R.H. Mellor ◽

C.C. Harland ◽

J.R. Levick ◽

...

Keyword(s):

Laser Treatment ◽

Dye Laser ◽

Pulsed Dye Laser ◽

Structural Abnormalities ◽

Before And After

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Endoscopic pulsed dye laser lithotripsy of gallbladder calculi in vivo

Gastrointestinal Endoscopy ◽

10.1016/s0016-5107(91)70672-x ◽

1991 ◽

Vol 37 (2) ◽

pp. 143-146 ◽

Cited By ~ 3

Author(s):

Daniel P. O’Leary ◽

David R. Cave ◽

Alan Greenfield ◽

Eva Kuligowska ◽

Desmond H. Birkett

Keyword(s):

Laser Lithotripsy ◽

Dye Laser ◽

Pulsed Dye Laser

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Confocal imaging of sebaceous gland hyperplasia in vivo to assess efficacy and mechanism of pulsed dye laser treatment

Lasers in Surgery and Medicine ◽

10.1002/(sici)1096-9101(1999)25:1<8::aid-lsm2>3.0.co;2-8 ◽

1999 ◽

Vol 25 (1) ◽

pp. 8-12 ◽

Cited By ~ 43

Author(s):

Salvador Gonz�lez ◽

W. Matthew White ◽

Milind Rajadhyaksha ◽

R. Rox Anderson ◽

Ernesto Gonz�lez

Keyword(s):

Laser Treatment ◽

Sebaceous Gland ◽

Dye Laser ◽

Confocal Imaging ◽

Pulsed Dye Laser

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Pulsed dye laser lithotripsy of submandibular gland salivary calculus

The Journal of Laryngology & Otology ◽

10.1017/s0022215100135418 ◽

1996 ◽

Vol 110 (10) ◽

pp. 942-946 ◽

Cited By ~ 27

Author(s):

Hirotaka Ito ◽

Shunkichi Baba

Keyword(s):

Submandibular Gland ◽

Pulse Width ◽

Shock Wave Lithotripsy ◽

Salivary Flow ◽

Laser Lithotripsy ◽

Dye Laser ◽

Pulsed Dye Laser ◽

Outpatient Basis ◽

Reflection Spectra

AbstractAn in vivo study was performed to evaluate the use of pulsed-dye laser beam for the fragmentation of salivary calculus. In accordance with the absorption and reflection spectra of sections of salivary stones, optimal fragmentation was achieved with a pulsed-dye laser with a pulse width of 1.4 μm and tuned to a wavelength of 504 nm. Further studies on particle size were conducted, and a new “sialoendoscope” technique was developed. Fifteen patients with sialolithiasis of the submandibular gland were treated. Under continuous endoscopic monitoring laser-induced shock wave lithotripsy was performed. In six patients complete fragmentation and removal of the salivary stones was achieved and in another patient 50 per cent fragmentation was sufficient to restore salivary flow. Laser lithotripsy of salivary stones with endoscopic monitoring permits treatment on an outpatient basis with little inconvenience to the patient, and this is a breakthrough in otolaryngology.

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