scholarly journals Change in the developmental fate of the chick optic vesicle from the neural retina to the telencephalon

2019 ◽  
Vol 61 (3) ◽  
pp. 252-262
Author(s):  
Misaki Shirahama ◽  
Ichie Steinfeld ◽  
Akari Karaiwa ◽  
Shigeru Taketani ◽  
Astrid Vogel‐Höpker ◽  
...  
Keyword(s):  
Neural Retina ◽  
Optic Vesicle ◽  
Developmental Fate

The Msh-like homeobox genes define domains in the developing vertebrate eye

Development ◽  
1991 ◽  
Vol 112 (4) ◽  
pp. 1053-1061 ◽  
Author(s):  
A.P. Monaghan ◽  
D.R. Davidson ◽  
C. Sime ◽  
E. Graham ◽  
R. Baldock ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Ciliary Body ◽  
Cellular Differentiation ◽  
Temporal Relationship ◽  
Chromosomal Location ◽  
Neural Retina ◽  
Optic Vesicle ◽  
Surface Ectoderm ◽  
Optic Cup ◽  
Vertebrate Eye

The mouse Hox-7.1 gene has previously been shown to be related to the Drosophila Msh homeobox-containing gene. Here we report the isolation of a new member of this family which resides at an unlinked chromosomal location and has been designated Hox-8.1. Both Hox-7.1 and Hox-8.1 are expressed in the mouse embryo during the early stages of eye development in a distinct spatial and temporal relationship. Hox-8.1 is expressed in the surface ectoderm and in the optic vesicle before invagination occurs in regions corresponding to the prospective corneal epithelium and neural retina, respectively. Hox-7.1 is expressed after formation of the optic cup, marking the domain that will give rise to the ciliary body. The activity of these genes indicates that the inner layer of the optic cup is differentiated into three distinct compartments before overt cellular differentiation occurs. Our results suggest that these genes are involved in defining the region that gives rise to the inner layer of the optic cup and in patterning this tissue to define the iris, ciliary body and retina.

Induction of scleral cartilage in the chorioallantois of the chick embryo

1969 ◽  
Vol 47 (1) ◽  
pp. 142-143 ◽  
Author(s):  
D. E. Wedlock ◽  
D. J. McCallion
Keyword(s):  
Chick Embryo ◽  
Neural Retina ◽  
Optic Vesicle ◽  
Young Chick ◽  
Cartilage Formation

The optic vesicle of the young chick embryo explanted to the chorioallantois of host embryos induces the formation of scleral cartilage in the chorioallantoic mesenchyme. The part of the optic vesicle responsible for the induction of cartilage is the pigmented retina. Neural retina does not induce cartilage formation.

Patterning the optic neuroepithelium by FGF signaling and Ras activation

Development ◽  
2001 ◽  
Vol 128 (24) ◽  
pp. 5051-5060 ◽  
Author(s):  
Shulei Zhao ◽  
Fang-Cheng Hung ◽  
Jennifer S. Colvin ◽  
Andrew White ◽  
Weilie Dai ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Neural Differentiation ◽  
Molecular Mechanisms ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Ectopic Expression ◽  
Neural Retina ◽  
Proximal Region ◽  
Optic Vesicle ◽  
Neural Tissues

During vertebrate embryogenesis, the neuroectoderm differentiates into neural tissues and also into non-neural tissues such as the choroid plexus in the brain and the retinal pigment epithelium in the eye. The molecular mechanisms that pattern neural and non-neural tissues within the neuroectoderm remain unknown. We report that FGF9 is normally expressed in the distal region of the optic vesicle that is destined to become the neural retina, suggesting a role in neural patterning in the optic neuroepithelium. Ectopic expression of FGF9 in the proximal region of the optic vesicle extends neural differentiation into the presumptive retinal pigment epithelium, resulting in a duplicate neural retina in transgenic mice. Ectopic expression of constitutively active Ras is also sufficient to convert the retinal pigment epithelium to neural retina, suggesting that Ras-mediated signaling may be involved in neural differentiation in the immature optic vesicle. The original and the duplicate neural retinae differentiate and laminate with mirror-image polarity in the absence of an RPE, suggesting that the program of neuronal differentiation in the retina is autonomously regulated. In mouse embryos lacking FGF9, the retinal pigment epithelium extends into the presumptive neural retina, indicating a role of FGF9 in defining the boundary of the neural retina.

scholarly journals Extraocular dorsal signal affects the developmental fate of the optic vesicle and patterns the optic neuroepithelium

2005 ◽  
Vol 47 (8) ◽  
pp. 523-536 ◽  
Author(s):  
Yuka Kagiyama ◽  
Nanaka Gotouda ◽  
Kiyo Sakagami ◽  
Kunio Yasuda ◽  
Makoto Mochii ◽  
...  
Keyword(s):  
Optic Vesicle ◽  
Developmental Fate

Lens differentiation in vitro in the absence of optic vesicle in the epiblast of chick blastoderm under the influence of skin dermis

Development ◽  
1972 ◽  
Vol 28 (1) ◽  
pp. 117-132
Author(s):  
Takeo Mizuno
Keyword(s):  
Neural Retina ◽  
Cephalic Region ◽  
Optic Vesicle ◽  
Dorsal Skin ◽  
Chick Blastoderm ◽  
Tissue Interactions ◽  
Two Factors ◽  
Recombination Experiments ◽  
Specific Influence

1. Dissociation and recombination experiments in vitro were found useful for analysing inductive tissue interactions involved in lens differentiation in the chick.2. When the presumptive cephalic region (epiblast plus hypoblast) of the embryo at predefinitive streak to one-somite stage is cultivated in vitro combined with the dermis isolated either from the dorsal skin of 6·5-day embryo or from the 13·5-day tarsometatarsal skin, a lens with fibres or lentoid is produced in the epiblast. In no case is there an optic vesicle present in the explant. 3. When the presumptive cephalic region (epiblast plus hypoblast) is cultivated without dermis, the lens is no longer formed. 4. If the epiblast alone, dissociated from the hypoblast of the presumptive cephalic region, is recombined with the dermis of the 6·5-day dorsal skin, lenses or lentoids fail to develop. 5. Cultivation of the epiblast alone cannot cause differentiation of the lens or lentoid. 6. The dermis can be replaced by other mesenchymes or embryonic organs: gizzard mesenchyme, mesonephros, sclerotome, liver and neural retina, though they are less effective than the dermis in producing lenses or lentoids in the epiblast. 7. It may therefore be concluded that the lens is induced in vitro by the actions of at least two factors: the epiblast first becomes competent under the specific influence of the hypoblast of the cephalic region. The lens will then differentiate from the competent epiblast by the non-specific action of various tissues such as the skin dermis, mesonephros, or sclerotome. 8. The primary stage of lens induction (action of the hypoblast on the epiblast) seems not yet completed by streak stage.

scholarly journals Lhx1 in the proximal region of the optic vesicle permits neural retina development in the chicken

Biology Open ◽  
2012 ◽  
Vol 1 (11) ◽  
pp. 1083-1093 ◽  
Author(s):  
T. Kawaue ◽  
M. Okamoto ◽  
A. Matsuyo ◽  
J. Inoue ◽  
Y. Ueda ◽  
...  
Keyword(s):  
Neural Retina ◽  
Proximal Region ◽  
Optic Vesicle ◽  
Retina Development

FGF1 patterns the optic vesicle by directing the placement of the neural retina domain

Development ◽  
1998 ◽  
Vol 125 (5) ◽  
pp. 869-877 ◽  
Author(s):  
J. Hyer ◽  
T. Mima ◽  
T. Mikawa
Keyword(s):  
Neural Retina ◽  
Expression Vectors ◽  
Expression Data ◽  
Optic Vesicle ◽  
Surface Ectoderm ◽  
Pigmented Epithelium ◽  
Optic Vesicles ◽  
Cell Phenotypes

Patterning of the bipotential retinal primordia (the optic vesicles) into neural retina and retinal pigmented epithelium depends on its interaction with overlaying surface ectoderm. The surface ectoderm expresses FGFs and the optic vesicles express FGF receptors. Previous FGF-expression data and in vitro analyses support the hypothesis that FGF signaling plays a significant role in patterning the optic vesicle. To test this hypothesis in vivo we removed surface ectoderm, a rich source of FGFs. This ablation generated retinas in which neural and pigmented cell phenotypes were co-mingled. Two in vivo protocols were used to replace FGF secretion by surface ectoderm: (1) implantation of FGF-secreting fibroblasts, and (2) injection of replication-incompetent FGF retroviral expression vectors. The retinas in such embryos exhibited segregated neural and pigmented epithelial domains. The neural retina domains were always close to a source of FGF secretion. These results indicate that, in the absense of surface ectoderm, cells of the optic vesicles display both neural and pigmented retinal phenotypes, and that positional cues provided by FGF organize the bipotential optic vesicle into specific neural retina and pigmented epithelium domains. We conclude that FGF can mimic one of the earliest functions of surface ectoderm during eye development, namely the demarcation of neural retina from pigmented epithelium.

Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick

Development ◽  
2000 ◽  
Vol 127 (21) ◽  
pp. 4599-4609 ◽  
Author(s):  
S. Fuhrmann ◽  
E.M. Levine ◽  
T.A. Reh
Keyword(s):  
Matrix Protein ◽  
Eye Development ◽  
Neural Retina ◽  
Optic Vesicle ◽  
Lateral Plate ◽  
Surface Ectoderm ◽  
Eye Growth ◽  
Pigmented Epithelium ◽  
Optic Vesicles ◽  
Vertebrate Eye

The vertebrate eye develops from the neuroepithelium of the ventral forebrain by the evagination and formation of the optic vesicle. Classical embryological studies have shown that the surrounding extraocular tissues - the surface ectoderm and extraocular mesenchyme - are necessary for normal eye growth and differentiation. We have used explant cultures of chick optic vesicles to study the regulation of retinal pigmented epithelium (RPE) patterning and differentiation during early eye development. Our results show that extraocular mesenchyme is required for the induction and maintenance of expression of the RPE-specific genes Mitf and Wnt13 and the melanosomal matrix protein MMP115. In the absence of extraocular tissues, RPE development did not occur. Replacement of the extraocular mesenchyme with cranial mesenchyme, but not lateral plate mesoderm, could rescue expression of the RPE-marker Mitf. In addition to activating expression of RPE-specific genes, the extraocular mesenchyme inhibits the expression of the neural retina-specific transcription factor Chx10 and downregulates the eye-specific transcription factors Pax6 and Optx2. The TGF(β) family member activin can substitute for the extraocular mesenchyme by promoting expression of the RPE-specific genes and downregulating expression of the neural retina-specific markers. These data indicate that extraocular mesenchyme, and possibly an activin-like signal, pattern the domains of the optic vesicle into RPE and neural retina.

Incredibly detailed embryo maps chart each cell’s developmental fate

Nature ◽  
2018 ◽  
Author(s):  
Heidi Ledford
Keyword(s):  
Developmental Fate
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