Restrictive versus Liberal Transfusion in Patients with Diabetes Undergoing Cardiac Surgery: An Open‐Label Randomized, Blinded Outcome Evaluation Trial

2021 ◽  
Author(s):  
Nikhil Mistry ◽  
Nadine Shehata ◽  
Paula Carmona ◽  
Daniel Bolliger ◽  
Raymond Hu ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Outcome Evaluation ◽  
Open Label ◽  
Patients With Diabetes ◽  
Evaluation Trial ◽  
Liberal Transfusion

Restrictive or liberal transfusion for cardiac surgery: Spanish results of a randomized multicenter international parallel open-label clinical trial

2020 ◽  
Author(s):  
J. Galan ◽  
E. Mateo ◽  
P. Carmona ◽  
L. Gajate ◽  
C.D. Mazer ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cardiac Surgery ◽  
Open Label ◽  
Liberal Transfusion

Restrictive or liberal transfusion for cardiac surgery: Spanish results of a randomized multicenter international parallel open-label clinical trial

2022 ◽  
Vol 46 (1) ◽  
pp. 53-57
Author(s):  
J. Galan ◽  
E. Mateo ◽  
P. Carmona ◽  
L. Gajate ◽  
C.D. Mazer ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cardiac Surgery ◽  
Open Label ◽  
Liberal Transfusion

scholarly journals Effect of perioperative β blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial

BMJ ◽  
2006 ◽  
Vol 332 (7556) ◽  
pp. 1482 ◽  
Author(s):  
Anne Benedicte Juul ◽  
J⊘rn Wetterslev ◽  
Christian Gluud ◽  
Allan Kofoed-Enevoldsen ◽  
Gorm Jensen ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Multicentre Trial ◽  
Patients With Diabetes

scholarly journals Clinical Outcome Evaluation of Primary Total Knee Arthroplasty in Patients with Diabetes Mellitus

2017 ◽  
Vol 23 ◽  
pp. 2198-2202 ◽  
Author(s):  
Pengcheng Liu ◽  
Junfeng Liu ◽  
Kuo Xia ◽  
Liyang Chen ◽  
Xing Wu
Keyword(s):  
Diabetes Mellitus ◽  
Total Knee Arthroplasty ◽  
Clinical Outcome ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Outcome Evaluation ◽  
Patients With Diabetes ◽  
Total Knee ◽  
Primary Total Knee

scholarly journals Multicentre, open-label, randomised, controlled clinical trial comparing 2% chlorhexidine–70% isopropanol and 5% povidone iodine–69% ethanol for skin antisepsis in reducing surgical-site infection after cardiac surgery: the CLEAN 2 study protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e026929
Author(s):  
Matthieu Boisson ◽  
Pierre Corbi ◽  
Thomas Kerforne ◽  
Lionel Camilleri ◽  
Mathieu Debauchez ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cardiac Surgery ◽  
Povidone Iodine ◽  
Controlled Clinical Trial ◽  
Site Infection ◽  
Open Label ◽  
Initial Surgery ◽  
Randomised Controlled Clinical Trial ◽  
Skin Antisepsis ◽  
Randomised Controlled

Introduction Surgical-site infection (SSI) is the second most frequent cause of healthcare-associated infection worldwide and is associated with increased morbidity, mortality and healthcare costs. Cardiac surgery is clean surgery with low incidence of SSI, ranging from 2% to 5%, but with potentially severe consequences. Perioperative skin antisepsis with an alcohol-based antiseptic solution is recommended to prevent SSI, but the superiority of chlorhexidine (CHG)–alcohol over povidone iodine (PVI)–alcohol, the two most common alcohol-based antiseptic solutions used worldwide, is controversial. We aim to evaluate whether 2% CHG–70% isopropanol is more effective than 5% PVI–69% ethanol in reducing the incidence of reoperation after cardiac surgery. Methods and analysis The CLEAN 2 study is a multicentre, open-label, randomised, controlled clinical trial of 4100 patients undergoing cardiac surgery. Patients will be randomised in 1:1 ratio to receive either 2% CHG–70% isopropanol or 5% PVI–69% ethanol for perioperative skin preparation. The primary endpoint is the proportion of patients undergoing any re-sternotomy between day 0 and day 90 after initial surgery and/or any reoperation on saphenous vein/radial artery surgical site between day 0 and day 30 after initial surgery. Data will be analysed on the intention-to-treat principle. Ethics and dissemination This protocol has been approved by an independent ethics committee and will be carried out according to the principles of the Declaration of Helsinki and the Good Clinical Practice guidelines. The results of this study will be disseminated through presentation at scientific conferences and publication in peer-reviewed journals. Trial registration number EudraCT 2017-005169-33 and NCT03560193.

scholarly journals Six‐month outcomes after restrictive or liberal transfusion for cardiac surgery (TRICS III trial)

2019 ◽  
Vol 29 (2) ◽  
pp. 77-79 ◽  
Author(s):  
L. J. Estcourt ◽  
D. J. Roberts
Keyword(s):  
Cardiac Surgery ◽  
Liberal Transfusion

scholarly journals The effect of restrictive versus liberal transfusion strategies on longer-term outcomes after cardiac surgery: a systematic review and meta-analysis with trial sequential analysis

2020 ◽  
Vol 67 (5) ◽  
pp. 577-587 ◽  
Author(s):  
Hessam H. Kashani ◽  
Carly Lodewyks ◽  
Morvarid S. Kavosh ◽  
Maya M. Jeyaraman ◽  
Christine Neilson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Surgery ◽  
Sequential Analysis ◽  
Meta Analysis ◽  
Trial Sequential Analysis ◽  
Liberal Transfusion

scholarly journals First open label study to investigate the use, safety and tolerability of octaplaslg® in patient blood management in two cardiac surgery centres in France

2020 ◽  
Vol 34 ◽  
pp. S44-S45
Author(s):  
A. Aouifi ◽  
J.-F. Charbonnel ◽  
E. Lapeyre ◽  
V. Frebault ◽  
M. Pasquié ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Patient Blood Management ◽  
Blood Management ◽  
Open Label ◽  
Open Label Study ◽  
Label Study
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