Presence or absence of intestinal metaplasia but not its burden is associated with prevalent high-grade dysplasia and cancer in Barrett's esophagus

2013 ◽  
Vol 27 (8) ◽  
pp. 751-756 ◽  
Author(s):  
A. Bansal ◽  
D. H. McGregor ◽  
O. Anand ◽  
M. Singh ◽  
D. Rao ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
High Grade Dysplasia ◽  
High Grade

scholarly journals Outcomes of Radiofrequency Ablation for Dysplastic Barrett’s Esophagus: A Comprehensive Review

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Carmelo Luigiano ◽  
Giuseppe Iabichino ◽  
Leonardo Henry Eusebi ◽  
Monica Arena ◽  
Pierluigi Consolo ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Intestinal Metaplasia ◽  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
High Grade Dysplasia ◽  
Endoscopic Management ◽  
Low Grade ◽  
High Grade ◽  
Neoplastic Progression

Barrett’s esophagus is a condition in which the normal squamous lining of the esophagus has been replaced by columnar epithelium containing intestinal metaplasia induced by recurrent mucosal injury related to gastroesophageal reflux disease. Barrett’s esophagus is a premalignant condition that can progress through a dysplasia-carcinoma sequence to esophageal adenocarcinoma. Multiple endoscopic ablative techniques have been developed with the goal of eradicating Barrett’s esophagus and preventing neoplastic progression to esophageal adenocarcinoma. For patients with high-grade dysplasia or intramucosal neoplasia, radiofrequency ablation with or without endoscopic resection for visible lesions is currently the most effective and safe treatment available. Recent data demonstrate that, in patients with Barrett’s esophagus and low-grade dysplasia confirmed by a second pathologist, ablative therapy results in a statistically significant reduction in progression to high-grade dysplasia and esophageal adenocarcinoma. Treatment of dysplastic Barrett’s esophagus with radiofrequency ablation results in complete eradication of both dysplasia and of intestinal metaplasia in a high proportion of patients with a low incidence of adverse events. A high proportion of treated patients maintain the neosquamous epithelium after successful treatment without recurrence of intestinal metaplasia. Following successful endoscopic treatment, endoscopic surveillance should be continued to detect any recurrent intestinal metaplasia and/or dysplasia. This paper reviews all relevant publications on the endoscopic management of Barrett’s esophagus using radiofrequency ablation.

Argon beam plasma coagulation as therapy for high-grade dysplasia in Barrett's esophagus

2003 ◽  
Vol 1 (4) ◽  
pp. 258-263 ◽  
Author(s):  
Stephen E. A. Attwood ◽  
Christopher J. Lewis ◽  
Scott Caplin ◽  
Karla Hemming ◽  
Gordon Armstrong
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Plasma Coagulation ◽  
Beam Plasma

Barrett's esophagus with high-grade dysplasia: An indication for esophagectomy?

1992 ◽  
Vol 54 (2) ◽  
pp. 199-204 ◽  
Author(s):  
Manuel Pera ◽  
Victor F. Trastek ◽  
Herschel A. Carpenter ◽  
Mark S. Allen ◽  
Claude Deschamps ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
High Grade Dysplasia ◽  
High Grade
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