Myocardial deformation and acute cellular rejection after heart transplantation: Impact of inter‐vendor variability in diagnostic effectiveness

2019 ◽  
Vol 36 (12) ◽  
pp. 2185-2194 ◽  
Author(s):  
Martín Ruiz‐Ortiz ◽  
Sara Rodriguez‐Diego ◽  
Mónica Delgado ◽  
Jiwon Kim ◽  
Jonathan W. Weinsaft ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Acute Cellular Rejection ◽  
Myocardial Deformation ◽  
Cellular Rejection

scholarly journals Correction to: Usefulness of speckle tracking echocardiography and biomarkers for detecting acute cellular rejection after heart transplantation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Cecilia Beatriz Bittencourt Viana Cruz ◽  
Ludhmila A. Hajjar ◽  
Fernando Bacal ◽  
Marco S. Lofrano-Alves ◽  
Márcio S. M. Lima ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Acute Cellular Rejection ◽  
Cellular Rejection

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Usefulness of Speckle Tracking Echocardiography and Biomarkers for Detecting Acute Cellular Rejection After Heart Transplantation

2020 ◽  
Author(s):  
Cecília Beatriz Bittencourt Viana Cruz ◽  
Ludhmila A. Hajjar ◽  
Fernando Bacal ◽  
Marco S. Lofrano-Alves ◽  
Márcio S.M. Lima ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Right Ventricular ◽  
Speckle Tracking ◽  
Troponin I ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular ◽  
Acute Cellular Rejection ◽  
Control Group ◽  
Transplant Patients ◽  
Cellular Rejection

Abstract Background: Acute cellular rejection (ACR) is a major complication after heart transplantation. Endomyocardial biopsy (EMB) remains the gold standard for its diagnosis, but it has concerning complications. We evaluated the usefulness of speckle tracking echocardiography (STE) and biomarkers for detecting ACR after heart transplantation.Methods: We prospectively studied 60 transplant patients with normal left and right ventricular systolic function who underwent EMB for surveillance six months after transplantation. Sixty age- and sex-matched healthy individuals constituted the control group. Conventional echocardiographic parameters, left ventricular global longitudinal, radial and circumferential strain (LV-GLS, LV-GRS and LV-GCS, respectively), left ventricular systolic twist (LV-twist) and right ventricular free wall longitudinal strain (RV-FWLS) were analyzed just before the procedure. We also measured biomarkers at the same moment. Results: Among the included 60 patients, 17 (28%) had severe ACR (grade ≥ 2R), and 43 (72%) had no significant ACR (grade 0 – 1R). The absolute values of LV-GLS, LV-twist and RV-FWLS were lower in transplant patients with ACR degree ≥ 2 R than in those without ACR (12.5% ± 2.9% vs 14.8% ± 2.3%, p=0.002; 13.9° ± 4.8° vs 17.1° ± 3.2°, p=0.048; 21.4%± 3.2% vs 16.6% ± 2.9%, p<0.001; respectively), while no differences were observed between the LV-GRS or LV-GCS. All of these parameters were lower in the transplant group without ACR than in the nontransplant control group, except for the LV-twist. Cardiac troponin I levels were significantly higher in patients with significant ACR than in patients without significant ACR [0.19 ng/mL (0.09–1.31) vs. 0.05 ng/mL (0.01–0.18), p=0.007]. The combination of troponin with LV-GLS, RV FWLS and LV-Twist had an AUC (area under curve) for the detection of ACR of 0.80 (0.68 – 0.92), 0.89 (0.81 – 0.93) and 0.79 (0.66 – 0.92), respectively. Conclusion: Heart transplant patients have altered left ventricular dynamics compared with control individuals. The combination of troponin with strain parameters had higher accuracy for the detection of ACR than the isolated variables and this association might select patients with a higher risk for ACR who will benefit from an EMB procedure in the first year after heart transplantation.

scholarly journals Three-Dimensional Self-Navigated T2 Mapping for the Detection of Acute Cellular Rejection After Orthotopic Heart Transplantation

2017 ◽  
Vol 3 (4) ◽  
pp. e149 ◽  
Author(s):  
Ruud B. van Heeswijk ◽  
Davide Piccini ◽  
Piergiorgio Tozzi ◽  
Samuel Rotman ◽  
Philippe Meyer ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
T2 Mapping ◽  
Three Dimensional ◽  
Acute Cellular Rejection ◽  
Orthotopic Heart Transplantation ◽  
Cellular Rejection

High-Sensitivity Cardiac Troponin is not Associated with Acute Cellular Rejection after Heart Transplantation

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sarah J Fitzsimons ◽  
Jonathan D.W. Evans ◽  
Doris M Rassl ◽  
Kuan Ken Lee ◽  
Fiona E Strachan ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Cardiac Troponin ◽  
High Sensitivity ◽  
Acute Cellular Rejection ◽  
Cellular Rejection

The Evaluation of Alterations in Myocardial Deformation during Therapy of Acute Cellular Rejection

2020 ◽  
Vol 39 (4) ◽  
pp. S258
Author(s):  
K. Antonczyk ◽  
R. Antonczyk ◽  
T. Niklewski ◽  
J. Malyszek-Tumidajewicz ◽  
M.O. Zembala ◽  
...  
Keyword(s):  
Acute Cellular Rejection ◽  
Myocardial Deformation ◽  
Cellular Rejection

scholarly journals LONGER BRAIN DEATH DURATION ASSOCIATED WITH INCREASED ACUTE CELLULAR REJECTION AFTER HEART TRANSPLANTATION

2016 ◽  
Vol 67 (13) ◽  
pp. 1367
Author(s):  
Derek Phan ◽  
Tamar Aintablian ◽  
Jignesh Patel ◽  
David Chang ◽  
Jon Kobashigawa
Keyword(s):  
Brain Death ◽  
Heart Transplantation ◽  
Acute Cellular Rejection ◽  
Cellular Rejection

scholarly journals P6030Levels of various microRNAs are altered in endomyocardial biopsies during acute cellular rejection in patients after heart transplantation

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
J. Novak ◽  
T. Machackova ◽  
J. Sana ◽  
T. Kafunkova ◽  
J. Godava ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Acute Cellular Rejection ◽  
Cellular Rejection
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