Myeloid sarcoma of the heart: Extramedullary relapse of acute myeloblastic leukemia, presenting with complete heart block and atrial flutter after second allogeneic stem cell transplantation

2021 ◽  
Author(s):  
Kadir Babaoğlu ◽  
Mehmet Azizoğlu ◽  
Eviç Zeynep Başar ◽  
Emine Zengin ◽  
Emre Usta ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Atrial Flutter ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Heart Block ◽  
Complete Heart Block ◽  
Acute Myeloblastic Leukemia ◽  
Myeloid Sarcoma ◽  
Extramedullary Relapse

Characterisation of extramedullary relapse in patients with chronic myeloid leukemia in advanced disease after allogeneic stem cell transplantation

2009 ◽  
Vol 50 (4) ◽  
pp. 551-558 ◽  
Author(s):  
Sunday Ocheni ◽  
Gabriela B. Iwanski ◽  
Philippe Schafhausen ◽  
Axel Rolf Zander ◽  
Francis Ayuk ◽  
...  
Keyword(s):  
Stem Cell ◽  
Chronic Myeloid Leukemia ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Myeloid Leukemia ◽  
Advanced Disease ◽  
Extramedullary Relapse

scholarly journals Isolated Mediastinal Myeloid Sarcoma Successfully Treated with Chemoradiotherapy Followed by Unrelated Allogeneic Stem Cell Transplantation

2011 ◽  
Vol 50 (24) ◽  
pp. 3003-3007 ◽  
Author(s):  
Jeong Mi Lee ◽  
Haa-Na Song ◽  
Yeojin Kang ◽  
Hosu Kim ◽  
Ji Hyun Min ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Myeloid Sarcoma

scholarly journals PS1053 IMPACT OF CYTOMEGALOVIRUS REACTIVATION ON RELAPSE RATE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION IN PATIENTS WITH ACUTE MYELOBLASTIC LEUKEMIA

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 476
Author(s):  
N. Ben Abdeljelil ◽  
M. Ben Hmida ◽  
R. Ouerghi ◽  
A. Lakhal ◽  
R. El Fatmi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Relapse Rate ◽  
Allogeneic Stem Cell Transplantation ◽  
Acute Myeloblastic Leukemia ◽  
Cytomegalovirus Reactivation

Clinical Characteristics and Outcome of Isolated Extramedullary Relapse in Acute Leukemia Following Allogeneic Stem Cell Transplantation: A Single Institutional Analysis

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4211-4211
Author(s):  
Jimin Shi ◽  
Xiaojian Meng ◽  
Yi Luo ◽  
Yamin Tan ◽  
Xiaoli Zhu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Acute Leukemia ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Univariate Analysis ◽  
Bone Marrow Involvement ◽  
Molecular Abnormalities ◽  
Extramedullary Relapse

Abstract Abstract 4211 Isolated extramedullary relapse (EMR) of acute leukemia (AL) is a rare occurrence although it appears to be more common following allogeneic stem cell transplantation (allo-SCT). To characterize what has been observed in isolated EMR, we investigated a total of 287 consecutive AL patients (144 acute myeloid leukemia, 138 acute lymphocytic leukemia and 5 acute mixed lineage leukemia) who underwent allo-SCT. Forty-seven (16.4%) patients experienced relapse after allo-SCT. 12 cases (4.2%) experienced relapse of extramedullary sites without concomitant bone marrow involvement. Isolated EMR accounted for 25.5% of the overall initial relapse. The time to relapse after allo-SCT was longer in the extramedullary sites than in the marrow (median, 10 months vs. 5.5 months, P<0.05,). Sites of EMR varied widely including central nervous system, skin, bone, pelvis and breasts. The variables considered for univariate analysis included donor gender, age, primary disease, disease status, cytogenetics/molecular abnormalities, preconditioning regimen, donor type, HLA match, aGVHD and cGVHD. The variables that showed significant correlation with isolated EMR were the cytogenetics abnormalities at diagnosis. The prognosis for patients who develop EMR remained poor but was relatively better than that after bone marrow (BM) relapse (overall survival, 10 vs. 18 months, P<0.05). Compared with local or single therapy, patients treated with systemic in combination with local treatment could yield favorable prognosis. Three patients survived 63, 55 and 49 months after transplant respectively, of whom two received DLI with subsequent chemotherapy and (or) irradiation and one had surgery with subsequent chemotherapy. In conclusion, we observed a significant number of isolated EMR of AL after allo-SCT and intensive approaches combined of local and systemic therapy can produce favorable response which may cure a percentage of these patients. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Isolated extramedullary relapse of acute lymphocytic leukemia in the maxilla after allogeneic stem cell transplantation

2011 ◽  
Vol 57 (12) ◽  
pp. 675-679
Author(s):  
Keinoshin WADA ◽  
Yumiko OHBAYASHI ◽  
Akinori IWASAKI ◽  
Takaaki OGAWA ◽  
Minoru MIYAKE ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Extramedullary Relapse
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