scholarly journals Endogenous elevation of plasma cholecystokinin does not prevent gallstones

2015 ◽  
Vol 45 (3) ◽  
pp. 237-246 ◽  
Author(s):  
Rafiq A. Shahid ◽  
David Q.-H. Wang ◽  
Brian E. Fee ◽  
Shannon J. McCall ◽  
Joelle M.-J. Romac ◽  
...  
Keyword(s):  
Plasma Cholecystokinin

Cholecystokinin is a Satiety Hormone in Humans at Physiological Post-Prandial Plasma Concentrations

1995 ◽  
Vol 89 (4) ◽  
pp. 375-381 ◽  
Author(s):  
Anne Ballinger ◽  
Lorraine McLoughlin ◽  
Sami Medbak ◽  
Michael Clark
Keyword(s):  
Food Intake ◽  
Test Meal ◽  
Plasma Concentrations ◽  
Standard Test ◽  
Saline Infusion ◽  
Reduce Food Intake ◽  
Subsequent Test ◽  
Gut Hormone ◽  
Plasma Cholecystokinin ◽  
Satiety Hormone

1. Intravenous infusions of the brain/gut hormone, cholecystokinin, have been shown to reduce food intake in a subsequent test meal. However, in previous studies the doses administered were large and likely to have produced plasma concentrations far in excess of the normal post-prandial range. 2. In this study cholecystokinin-8 was infused intravenously to six healthy subjects in doses that reproduced physiological post-prandial concentrations. Plasma concentrations of cholecystokinin were measured using a novel sensitive and specific radioimmunoassay. The effect of cholecystokinin-8 infusion on subsequent food intake in a standard test meal was compared with the effect of saline infusion in the same subjects. 3. Food intake (mean ± SEM) was significantly less during cholecystokinin (5092 ± 665 kJ) than during saline infusion (6418 ± 723 kJ, P = 0.03). During cholecystokinin infusion, plasma concentrations increased from 0.45 ± 0.06 pmol/l to 7.28 ± 2.43 pmol/l immediately before the meal. With saline infusion there was no premeal increase in plasma cholecystokinin concentration. 4. This paper describes a novel radioimmunoassay for measurement of plasma concentrations of cholecystokinin. Using this assay we have demonstrated that cholecystokinin is important in control of satiety in humans.

Plasma Cholecystokinin-8 in Pigs With Divergent Genetic Potential for Feed Intake and Growth

1998 ◽  
Vol 15 (1) ◽  
pp. 9-21 ◽  
Author(s):  
A.C Clutter ◽  
R Jiang ◽  
J.P McCann ◽  
D.S Buchanan
Keyword(s):  
Feed Intake ◽  
Genetic Potential ◽  
Plasma Cholecystokinin

Effect of bile salt binding or protease inactivation on plasma cholecystokinin and gallbladder responses to bombesin

1994 ◽  
Vol 107 (6) ◽  
pp. 1627-1635 ◽  
Author(s):  
Paul W.L. Thimister ◽  
Wim P.M. Hopman ◽  
Cornelius E.J. Sloots ◽  
Gerd Rosenbusch ◽  
Albert Tangerman ◽  
...  
Keyword(s):  
Bile Salt ◽  
Plasma Cholecystokinin

scholarly journals Plasma cholecystokinin concentrations in 3-day-old lambs: effect of the duration of fasting preceding a sucking bout

1997 ◽  
Vol 37 (5) ◽  
pp. 551-558 ◽  
Author(s):  
R. Nowak ◽  
P. Orgeur ◽  
V. Piketty ◽  
P. Alster ◽  
R. Andersson ◽  
...  
Keyword(s):  
Plasma Cholecystokinin

Plasma Cholecystokinin Levels in Acute Pancreatitis

Pancreas ◽  
1997 ◽  
Vol 14 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Hisashi Shirohara ◽  
Makoto Otsuki
Keyword(s):  
Acute Pancreatitis ◽  
Plasma Cholecystokinin

scholarly journals Physical state of meal affects gastric emptying, cholecystokinin release and satiety

1998 ◽  
Vol 80 (6) ◽  
pp. 521-527 ◽  
Author(s):  
A. Santangelo ◽  
M. Peracchi ◽  
D. Conte ◽  
M. Fraquelli ◽  
M. Porrini
Keyword(s):  
Gastric Emptying ◽  
Physical State ◽  
Eating Behaviour ◽  
Gastric Emptying Rate ◽  
Plasma Cholecystokinin ◽  
Influence Of Food ◽  
Gastric Emptying Time ◽  
Solid Liquid ◽  
Desire To Eat ◽  
Antral Area

To verify the influence of food consistency on satiety mechanisms we evaluated the effects of the same meal in solid–liquid (SM) and homogenized (HM) form on satiety sensation, gastric emptying rate and plasma cholecystokinin (CCK) concentration. Eight healthy men, aged 21-28 (mean 24·5) years were given two meals (cooked vegetables 250 g, cheese 35 g, croutons 50 g and olive oil 25 g, total energy 2573 kJ, with water 300 ml) differing only in physical state: SM and HM. The subjects consumed the meals in randomized order on non-consecutive days. The sensations of fullness, satiety and desire to eat were evaluated by means of a questionnaire, gastric emptying was assessed by ultrasonographic measurement of antral area, and plasma CCK concentration was measured by radioimmunoassay. The vegetable-rich meal was significantly more satiating (P< 0·05) when in the HM form than when eaten in a SM state. Furthermore, the overall gastric emptying time was significantly slowed (255 (sem11) min after HMv.214 (sem12) min after SM;P< 0·05) and CCK peak occurred later (94 (sem12) min after HMv.62 (sem11) min after SM; NS) when the food was consumed in the HM form. Independently of the type of meal, antral area was significantly related to fullness sensations (r20·46,P= 0·004). These results demonstrate that meal consistency is an important physical food characteristic which influences both gastric emptying rate and satiety sensation. Moreover, the relationship observed between antral area and fullness sensation confirms that antral distension plays a part in the regulation of eating behaviour.

Effect of Various Triglycerides on Plasma Cholecystokinin Levels in Rats

1990 ◽  
Vol 120 (7) ◽  
pp. 686-690 ◽  
Author(s):  
Bruce R. Douglas ◽  
Jan B. M. J. Jansen ◽  
Alfons J. L. de Jong ◽  
Cornelis B. H. W. Lamers
Keyword(s):  
Plasma Cholecystokinin

Changes in Rat Pancreas following Gastric Surgery Are Not Correlated with Basal Levels of Serum Gastrin or Plasma Cholecystokinin

1996 ◽  
Vol 13 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Jan Axelson ◽  
Masao Kobari ◽  
Jens F. Rehfeld ◽  
Ingemar Ihse
Keyword(s):  
Serum Gastrin ◽  
Gastric Surgery ◽  
Rat Pancreas ◽  
Plasma Cholecystokinin
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