scholarly journals Ionotropic glutamate receptor GluA4 and T‐type calcium channel Ca v 3.1 subunits control key aspects of synaptic transmission at the mouse L5B‐POm giant synapse

2015 ◽  
Vol 42 (12) ◽  
pp. 3033-3044 ◽  
Author(s):  
Min Seol ◽  
Thomas Kuner
2013 ◽  
Vol 41 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Gareth M. Thomas ◽  
Richard L. Huganir

In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only will aid our understanding of physiological neuronal regulation, but also may provide insights into, and even novel treatments for, neuropathological conditions. In the present paper, we review recent advances regarding the regulation of ionotropic glutamate receptor trafficking and function by palmitoylation.


1998 ◽  
Vol 57 (2) ◽  
pp. 211-220 ◽  
Author(s):  
Hsiu-Ming Chang ◽  
Yi-Mi Wu ◽  
Yen-Chung Chang ◽  
Yu-Chung Hsu ◽  
Hsiu-Ya Hsu ◽  
...  

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