A functional magnetic resonance imaging investigation of motor control in Gilles de la Tourette syndrome during imagined and executed movements

2015 ◽  
Vol 43 (4) ◽  
pp. 494-508 ◽  
Author(s):  
Laura Zapparoli ◽  
Mauro Porta ◽  
Martina Gandola ◽  
Paola Invernizzi ◽  
Valeria Colajanni ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Motor Control ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Tourette Syndrome ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

scholarly journals Altered sense of agency in Gilles de la Tourette syndrome: behavioural, clinical and functional magnetic resonance imaging findings

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Laura Zapparoli ◽  
Silvia Seghezzi ◽  
Francantonio Devoto ◽  
Marika Mariano ◽  
Giuseppe Banfi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Tourette Syndrome ◽  
Sense Of Agency ◽  
Healthy Controls ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Intentional Binding ◽  
Action Monitoring

Abstract Current neurocognitive models of motor control postulate that accurate action monitoring is crucial for a normal experience of agency—the ability to attribute the authorship of our actions and their consequences to ourselves. Recent studies demonstrated that action monitoring is impaired in Gilles de la Tourette syndrome, a movement disorder characterized by motor and vocal tics. It follows that Tourette syndrome patients may suffer from a perturbed sense of agency, the hypothesis tested in this study. To this end, we recruited 25 Tourette syndrome patients and 25 matched healthy controls in a case-control behavioural and functional magnetic resonance imaging study. As an implicit index of the sense of agency, we measured the intentional binding phenomenon, i.e., the perceived temporal compression between voluntary movements and their external consequences. We found evidence of an impaired sense of agency in Tourette syndrome patients who, as a group, did not show a significant intentional binding. The more reduced was the individual intentional binding, the more severe were the motor symptoms. Specific differences between the two groups were also observed in terms of brain activation patterns. In the healthy controls group, the magnitude of the intentional binding was associated with the activity of a premotor–parietal–cerebellar network. This relationship was not present in the Tourette syndrome group, suggesting an altered activation of the agency brain network for self-generated acts. We conclude that the less accurate action monitoring described in Tourette syndrome also involves the assessment of the consequences of actions in the outside world. We discuss that this may lead to difficulties in distinguishing external consequences produced by their own actions from the ones caused by others in Tourette syndrome patients.

scholarly journals Functional connectivity between the cerebellum and somatosensory areas implements the attenuation of self-generated touch

2019 ◽  
Author(s):  
Konstantina Kilteni ◽  
H. Henrik Ehrsson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Motor Control ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Functional Magnetic Resonance Imaging ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Neural Basis ◽  
Somatosensory Areas ◽  
Control Theories

AbstractSince the early 1970s, numerous behavioral studies have shown that self-generated touch feels less intense than the same touch applied externally. Computational motor control theories have suggested that cerebellar internal models predict the somatosensory consequences of our movements and that these predictions attenuate the perception of the actual touch. Despite this influential theoretical framework, little is known about the neural basis of this predictive attenuation. This is due to the limited number of neuroimaging studies, the presence of conflicting results about the role and the location of cerebellar activity, and the lack of behavioral measures accompanying the neural findings. Here, we combined psychophysics with functional magnetic resonance imaging to detect the neural processes underlying somatosensory attenuation in male and female healthy human participants. Activity in bilateral secondary somatosensory areas was attenuated when the touch was presented during a self-generated movement (self-generated touch) than in the absence of movement (external touch). An additional attenuation effect was observed in the cerebellum that is ipsilateral to the passive limb receiving the touch. Importantly, we further found that the degree of functional connectivity between the ipsilateral cerebellum and the contralateral primary and bilateral secondary somatosensory areas was linearly and positively related to the degree of behaviorally assessed attenuation; that is, the more participants perceptually attenuated their self-generated touches, the stronger this corticocerebellar coupling. Collectively, these results suggest that the ipsilateral cerebellum is fundamental in predicting self-generated touch and that this structure implements somatosensory attenuation via its functional connectivity with somatosensory areas.Significance statementWhen we touch our hand with the other, the resulting sensation feels less intense than when another person or a machine touches our hand with the same intensity. Early computational motor control theories have proposed that the cerebellum predicts and cancels the sensory consequences of our movements; however, the neural correlates of this cancelation remain unknown. By means of functional magnetic resonance imaging, we show that the more participants attenuate the perception of their self-generated touch, the stronger the functional connectivity between the cerebellum and the somatosensory cortical areas. This provides conclusive evidence about the role of the cerebellum in predicting the sensory feedback of our movements and in attenuating the associated percepts via its connections to early somatosensory areas.

Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot study

2004 ◽  
Vol 55 (9) ◽  
pp. 916-925 ◽  
Author(s):  
Tamara Hershey ◽  
Kevin J Black ◽  
Johanna M Hartlein ◽  
Deanna M Barch ◽  
Todd S Braver ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Pilot Study ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Tourette Syndrome ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

Evaluation of Causal Influences in Model of Motor Control in Left Hands Movement-Readiness State

2012 ◽  
Vol 195-196 ◽  
pp. 418-423
Author(s):  
Yu Qing Wang ◽  
Hua Fu Chen ◽  
Ling Zeng
Keyword(s):  
Magnetic Resonance Imaging ◽  
Motor Control ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Human Brain ◽  
Caudate Nucleus ◽  
Functional Coupling ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Cingulate Motor Area

The previous research revealed some functional coupling among nodes in model of motor control in human brain, which described nondirectional synchronous actions among these nodes during movement-readiness state. However, causal relationships among these nodes were still lack, which represented some directional interactions among these nodes in movement-readiness state. In the present study, we used functional magnetic resonance imaging (fMRI) and conditional Granger causality (CGC) method to investigate the interactions in model of motor control in movement-readiness state. Our result showed that upper precuneus and cingulate motor area revealed net causal influences with contralateral supplementary motor areas and contralateral caudate nucleus during the left hands movement-readiness state. Moreover, the results of Out-In degrees indicated that bilateral primary sensorimotor areas revealed competitive relationship during left hands movement-readiness.

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