Upregulation and axonal transport of synaptotagmin-IV in the direct-pathway medium spiny neurons in hemi-parkinsonian rats induced by dopamine D1 receptor stimulation

2016 ◽  
Vol 43 (7) ◽  
pp. 885-898 ◽  
Author(s):  
Larisa Tratnjek ◽  
Gordana Glavan ◽  
Tanja Višnjar ◽  
Marko Živin
Keyword(s):  
Axonal Transport ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Medium Spiny Neurons ◽  
Receptor Stimulation ◽  
Direct Pathway ◽  
Spiny Neurons ◽  
Synaptotagmin Iv

scholarly journals Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization

2011 ◽  
Vol 108 (10) ◽  
pp. 4206-4211 ◽  
Author(s):  
L. R. Beutler ◽  
M. J. Wanat ◽  
A. Quintana ◽  
E. Sanz ◽  
N. S. Bamford ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Activity ◽  
Medium Spiny Neurons ◽  
Spiny Neurons ◽  
Amphetamine Sensitization

scholarly journals Inhibitory ultrapotent chemogenetics activate dopamine D1 receptor-expressing medium spiny neurons

2020 ◽  
Author(s):  
Stephanie C. Gantz ◽  
Maria M. Ortiz ◽  
Andrew J. Belilos ◽  
Khaled Moussawi
Keyword(s):  
Brain Slices ◽  
Reversal Potential ◽  
Cell Types ◽  
Receptor Activation ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Medium Spiny Neurons ◽  
Inhibitory Function ◽  
Spiny Neurons

SUMMARYUltrapotent chemogenetics, including the chloride-permeable inhibitory PSAM4-GlyR receptor, were recently proposed as a powerful strategy to selectively control neuronal activity in awake, behaving animals. We aimed to validate the inhibitory function of PSAM4-GlyR in dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) in the ventral striatum. Activation of PSAM4-GlyR with the uPSEM792 ligand enhanced rather than suppressed the activity of D1-MSNs in vivo as indicated by increased c-fos expression in D1-MSNs. Whole-cell recordings in mouse brain slices showed that activation of PSAM4-GlyR did not inhibit firing of action potentials in D1-MSNs. Activation of PSAM4-GlyR depolarized D1-MSNs, attenuated GABAergic inhibition, and shifted the reversal potential of PSAM4-GlyR current to more depolarized potentials, perpetuating the depolarizing effect of receptor activation. The data show that ‘inhibitory’ PSAM4-GlyR chemogenetics may actually activate certain cell types, and highlight the pitfalls of utilizing chloride conductances to inhibit neurons.

Dopamine D1 receptor stimulation increases striatal acetylcholine release in the rat

1990 ◽  
Vol 186 (2-3) ◽  
pp. 335-338 ◽  
Author(s):  
Geert Damsma ◽  
Chui-Se Tham ◽  
George S. Robertson ◽  
Hans C. Fibiger
Keyword(s):  
Acetylcholine Release ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Stimulation

scholarly journals Fronto-striatal projections regulate approach-avoidance conflict

2020 ◽  
Author(s):  
Adrienne C. Loewke ◽  
Adelaide R. Minerva ◽  
Alexandra B. Nelson ◽  
Anatol C. Kreitzer ◽  
Lisa A. Gunaydin
Keyword(s):  
Anxiety Disorders ◽  
Avoidance Behavior ◽  
D1 Receptor ◽  
Projection Neurons ◽  
Medium Spiny Neurons ◽  
Neural Pathways ◽  
Spiny Neurons ◽  
Striatal Projection Neurons ◽  
Neural Computations ◽  
Approach Avoidance

ABSTRACTThe dorsomedial prefrontal cortex (dmPFC) has been linked to approach-avoidance behavior and decision-making under conflict, key neural computations thought to be altered in anxiety disorders. However, the heterogeneity of efferent prefrontal projections has obscured identification of the specific top-down neural pathways regulating these anxiety-related behaviors. While the dmPFC-amygdala circuit has long been implicated in controlling reflexive fear responses, recent work suggests that this circuit is less important for avoidance behavior. We hypothesized that dmPFC neurons projecting to the dorsomedial striatum (DMS) represent a subset of prefrontal neurons that robustly encode and drive approach-avoidance behavior. Using fiber photometry recording during the elevated zero maze (EZM) task, we show heightened neural activity in prefrontal and fronto-striatal projection neurons, but not fronto-amydalar projection neurons, during exploration of the anxiogenic open arms of the maze. Additionally, through pathway-specific optogenetics we demonstrate that this fronto-striatal projection preferentially excites postsynaptic D1 receptor-expressing medium spiny neurons in the DMS and bidirectionally controls avoidance behavior. We conclude that this striatal-projecting subpopulation of prefrontal neurons regulates approach-avoidance conflict, supporting a model for prefrontal control of defensive behavior in which the dmPFC-amygdala projection controls reflexive fear behavior and the dmPFC-striatum projection controls anxious avoidance behavior. Our findings identify this fronto-striatal circuit as a valuable therapeutic target for developing interventions to alleviate excessive avoidance behavior in anxiety disorders.

Dopamine D1-receptor stimulation reduces neostriatal cholecystokinin release

1984 ◽  
Vol 104 (3-4) ◽  
pp. 387-388 ◽  
Author(s):  
D.K. Meyer ◽  
A. Holland ◽  
U. Conzelmann
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Stimulation

Adenosine A1 receptor blockade selectively potentiates the motor effects induced by dopamine D1 receptor stimulation in rodents

1996 ◽  
Vol 218 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Patrizia Popoli ◽  
Lydia Giménez-Llort ◽  
Antonella Pezzola ◽  
Rosaria Reggio ◽  
Emili Martínez ◽  
...  
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Adenosine A1 Receptor ◽  
Receptor Blockade ◽  
Receptor Stimulation ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Motor Effects

scholarly journals Dopamine D1 Receptor-Mediated Transmission Maintains Information Flow Through the Cortico-Striato-Entopeduncular Direct Pathway to Release Movements

2015 ◽  
Vol 25 (12) ◽  
pp. 4885-4897 ◽  
Author(s):  
Satomi Chiken ◽  
Asako Sato ◽  
Chikara Ohta ◽  
Makoto Kurokawa ◽  
Satoshi Arai ◽  
...  
Keyword(s):  
Information Flow ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Direct Pathway ◽  
Flow Through

scholarly journals Involvement of the Striatal Medium Spiny Neurons of the Direct Pathway in the Motor Stimulant Effects of Phencyclidine

2015 ◽  
pp. pyv134 ◽  
Author(s):  
Alessandra Bonito-Oliva ◽  
Caitlin DuPont ◽  
Nather Madjid ◽  
Sven Ove Ögren ◽  
Gilberto Fisone
Keyword(s):  
Medium Spiny Neurons ◽  
Direct Pathway ◽  
Spiny Neurons
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