A subset of taste receptor cells express biocytin‐permeable channels activated by reducing extracellular Ca 2+ concentration

2020 ◽  
Vol 51 (7) ◽  
pp. 1605-1623
Author(s):  
Masafumi Iwamoto ◽  
Madoka Takashima ◽  
Yoshitaka Ohtubo
Keyword(s):  
Taste Receptor ◽  
Receptor Cells ◽  
Taste Receptor Cells

Taste Transductions in Taste Receptor Cells: Basic Tastes and Moreover

2014 ◽  
Vol 20 (16) ◽  
pp. 2684-2692 ◽  
Author(s):  
Shusuke Iwata ◽  
Ryusuke Yoshida ◽  
Yuzo Ninomiya
Keyword(s):  
Taste Receptor ◽  
Receptor Cells ◽  
Taste Receptor Cells

Age‐related electrophysiological changes in mouse taste receptor cells

2020 ◽  
Author(s):  
Keita Takeuchi ◽  
Kiyonori Yoshii ◽  
Yoshitaka Ohtubo
Keyword(s):  
Taste Receptor ◽  
Receptor Cells ◽  
Age Related ◽  
Taste Receptor Cells ◽  
Mouse Taste

scholarly journals Role for epithelial Na+channels and putative Na+/H+ exchangers in salt taste transduction in rats

1997 ◽  
Vol 273 (6) ◽  
pp. R1923-R1931 ◽  
Author(s):  
Robert F. Lundy ◽  
David W. Pittman ◽  
Robert J. Contreras
Keyword(s):  
Salt Concentration ◽  
Taste Receptor ◽  
Drug Dose ◽  
Chorda Tympani Nerve ◽  
Sprague Dawley ◽  
Salt Taste ◽  
Receptor Cells ◽  
Taste Transduction ◽  
Taste Receptor Cells ◽  
Dimethyl Amiloride

The effects of the epithelial Na+channel antagonists amiloride and benzamil and the Na+/H+exchange antagonist 5-( N, N-dimethyl)-amiloride (DMA)-Cl on the integrated responses of the chorda tympani nerve to 30, 75, 150, 300, and 500 mM concentrations of NaCl, KCl, and NH4Cl were assessed in male Sprague-Dawley rats. Based on evidence from other systems, 1 and 25 μM amiloride and benzamil were chosen to selectively inhibit epithelial Na+ channels and 1 μM DMA was chosen to selectively inhibit Na+/H+exchange. When added to stimulating salt solutions, amiloride, benzamil, and DMA were each effective in inhibiting responses to all three salts. The degree of inhibition varied with drug, salt, and salt concentration, but not drug dose. Amiloride suppressed NaCl responses to a greater degree than KCl and NH4Cl responses, whereas DMA suppressed NH4Cl responses to a greater degree than NaCl and KCl responses. In all but one case (25 μM amiloride added to KCl), drug suppression of taste nerve responses decreased with an increase in salt concentration. The present results suggest that 1) epithelial Na+ channels in rat taste receptor cells may play a role in KCl and NH4Cl taste transduction; 2) a Na+/H+exchange protein may be present in taste receptor cells, representing a putative component, in addition to epithelial Na+ channels, in salt taste transduction; and 3) salt taste detection and transduction may depend on the utilization of a combination of common and distinct transcellular pathways.

Amiloride-blockable sodium currents in isolated taste receptor cells

1988 ◽  
Vol 105 (3) ◽  
pp. 245-255 ◽  
Author(s):  
Patrick Avenet ◽  
Bernd Lindemann
Keyword(s):  
Taste Receptor ◽  
Sodium Currents ◽  
Receptor Cells ◽  
Taste Receptor Cells

Sweet and Salty: Transduction in Taste

Physiology ◽  
1995 ◽  
Vol 10 (4) ◽  
pp. 166-170
Author(s):  
B Lindemann
Keyword(s):  
Ion Channel ◽  
Molecular Cloning ◽  
Taste Receptor ◽  
Signal Pathways ◽  
Channel Activity ◽  
Patch Clamping ◽  
Receptor Cells ◽  
Intracellular Messengers ◽  
Taste Receptor Cells

Signal pathways in taste receptor cells reach from apical events, like binding of a tastant to a receptor, through intracellular processes and basolateral regenerative ion channel activity to the release of transmitter. The responses are now being investigated with patch clamping, monitoring of intracellular messengers including Ca2+, and molecular cloning.

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