Plasma progranulin levels in cortical dementia phenotypes with asymmetric perisylvian atrophy

2013 ◽  
Vol 20 (9) ◽  
pp. 1319-1324 ◽  
Author(s):  
E. Gómez-Tortosa ◽  
R. Guerrero-López ◽  
E. Gil-Neciga ◽  
E. Franco ◽  
T. del Ser ◽  
...  
Keyword(s):  
Cortical Dementia

scholarly journals A Comparative Study of the Behavioral Profile of the Behavioral Variant of Frontotemporal Dementia and Parkinson’s Disease Dementia

2020 ◽  
pp. 182-194
Author(s):  
Dinesh Saini ◽  
Adreesh Mukherjee ◽  
Arijit Roy ◽  
Atanu Biswas
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Frontotemporal Dementia ◽  
Severe Disease ◽  
Executive Dysfunction ◽  
Behavioral Symptoms ◽  
Parkinson’S Disease Dementia ◽  
Subcortical Dementia ◽  
Behavioral Profile ◽  
Cortical Dementia

<b><i>Background:</i></b> Executive dysfunction is the common thread between pure cortical dementia like the behavioral variant of frontotemporal dementia (bvFTD) and subcortical dementia like Parkinson’s disease dementia (PDD). Although there are clinical and cognitive features to differentiate cortical and subcortical dementia, the behavioral symptoms differentiating these 2 conditions are still not well known. <b><i>Objective:</i></b> To evaluate the behavioral profile of bvFTD and PDD and compare them to find out which behavioral symptoms can differentiate between the two. <b><i>Methods:</i></b> Twenty consecutive patients with bvFTD (&#x3e;1 year after diagnosis) and 20 PDD patients were recruited according to standard diagnostic criteria. Behavioral symptoms were collected from the reliable caregiver by means of a set of questionnaires and then compared between the 2 groups. <b><i>Results:</i></b> bvFTD patients had more severe disease and more behavioral symptoms than PDD. bvFTD patients were different from PDD patients due to their significantly greater: loss of basic emotion (<i>p</i> &#x3c; 0.001, odds ratio [OR] 44.33), loss of awareness of pain (<i>p</i> &#x3c; 0.001, OR 44.33), disinhibition (<i>p</i> &#x3c; 0.001, OR 35.29), utilization phenomenon (<i>p</i> = 0.008, OR 22.78), loss of taste discrimination (<i>p</i> &#x3c; 0.001, OR 17), neglect of hygiene (<i>p</i> = 0.001, OR 13.22), loss of embarrassment (<i>p</i> = 0.003, OR 10.52), wandering (<i>p</i> = 0.004, OR 9.33), pacing (<i>p</i> = 0.014, OR 9), selfishness (<i>p</i> = 0.014, OR 9), increased smoking (<i>p</i> = 0.014, OR 9), increased alcohol consumption (<i>p</i> = 0.031, OR 7.36), social avoidance (<i>p</i> = 0.012, OR 6.93), mutism (<i>p</i> = 0.041, OR 5.67), and failure to recognize objects (<i>p</i> = 0.027, OR 4.33). The bvFTD patients were also significantly less suspicious (<i>p</i> = 0.001, OR 0.0295), less inclined to have a false belief that people were in their home (<i>p</i> = 0.014, OR 0.11) and had fewer visual illusions/hallucinations (<i>p</i> = 0.004, OR 0.107) than PDD patients. <b><i>Conclusion:</i></b> Behavioral symptoms are helpful to distinguish bvFTD from PDD, and thus also cortical dementia with frontal-lobe dysfunction from subcortical dementia.

Cortical Dementia

2020 ◽  
pp. 560-560
Keyword(s):  
Cortical Dementia

P1-001: Screening of progranulin-caused FTD in cortical dementia phenotypes with asymmetric perisylvian atrophy

2012 ◽  
Vol 8 (4S_Part_3) ◽  
pp. P108-P108
Author(s):  
Estrella Gómez-Tortosa ◽  
Rosa Guerrero ◽  
Eulogio Gil-Neciga ◽  
Emilio Franco ◽  
Teodoro del Ser ◽  
...  
Keyword(s):  
Cortical Dementia

Visual Hallucinations and HLA Class II Antigens in Cortical Dementia

2010 ◽  
Vol 30 (1) ◽  
pp. 8-11 ◽  
Author(s):  
Estrella Gómez-Tortosa ◽  
Miriam Aguerri ◽  
M. José Sainz ◽  
Mireya Losada ◽  
Pedro J. García-Ruiz ◽  
...  
Keyword(s):  
Class Ii ◽  
Hla Class Ii ◽  
Visual Hallucinations ◽  
Cortical Dementia ◽  
Class Ii Antigens

Integration of Imaging in Cortical Dementia Diagnosis

2015 ◽  
Author(s):  
Chiara Cerami ◽  
Stefano F. Cappa
Keyword(s):  
Dementia Diagnosis ◽  
Cortical Dementia

scholarly journals A neuropsychological instrument adding to the description of patients with suspected cortical dementia: the Milan overall dementia assessment.

1994 ◽  
Vol 57 (12) ◽  
pp. 1510-1517 ◽  
Author(s):  
M Brazzelli ◽  
E Capitani ◽  
S Della Sala ◽  
H Spinnler ◽  
M Zuffi
Keyword(s):  
Cortical Dementia

The concept of subcortical and cortical dementia: Another look

1986 ◽  
Vol 19 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Peter J. Whitehouse
Keyword(s):  
Cortical Dementia

scholarly journals Dementia and communication pathology: Two case examples

1988 ◽  
Vol 35 (1) ◽  
Author(s):  
Claire Penn ◽  
Beulah Sonnenberg ◽  
Yael Schnaier
Keyword(s):  
Differential Diagnosis ◽  
Progressive Supranuclear Palsy ◽  
Explanatory Model ◽  
Subcortical Dementia ◽  
Case Examples ◽  
Female Patients ◽  
Dementia Of Alzheimer’S Type ◽  
Cortical Dementia

The discourse characteristics of two female patients with dementia are described — one patient with a cortical dementia of Alzheimer's type and one patient with a classical subcortical dementia of Progressive Supranuclear Palsy. Distinct patterns of breakdown were observed and related to an explanatory model. Implications of the findings for differential diagnosis are discussed and the neurological representation of the pragmatic level of language is considered.

scholarly journals Posterior cortical dementia with alexia: neurobehavioural, MRI, and PET findings.

1991 ◽  
Vol 54 (5) ◽  
pp. 443-448 ◽  
Author(s):  
L Freedman ◽  
D H Selchen ◽  
S E Black ◽  
R Kaplan ◽  
E S Garnett ◽  
...  
Keyword(s):  
Cortical Dementia

Visuospatial ability in cortical dementia

1991 ◽  
Vol 13 (5) ◽  
pp. 677-690 ◽  
Author(s):  
Lawrence Freedman ◽  
Lawrie E. Dexter
Keyword(s):  
Visuospatial Ability ◽  
Cortical Dementia
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