Neuromyelitis optica spectrum disorders: comparison of clinical and magnetic resonance imaging characteristics of AQP4‐IgG versus MOG‐IgG seropositive cases in the Netherlands

2015 ◽  
Vol 23 (3) ◽  
pp. 580-587 ◽  
Author(s):  
E. D. Pelt ◽  
Y. Y. M. Wong ◽  
I. A. Ketelslegers ◽  
D. Hamann ◽  
R. Q. Hintzen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
The Netherlands ◽  
Neuromyelitis Optica ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Resonance Imaging ◽  
Imaging Characteristics ◽  
Spectrum Disorders

scholarly journals COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibodies: Cause or coincidence?

2020 ◽  
pp. 135245852094998 ◽  
Author(s):  
Diogo Goulart Corrêa ◽  
Fabiana Cavalcanti de Souza Lima ◽  
Daniel da Cruz Bezerra ◽  
Antônio Carlos Coutinho ◽  
Luiz Celso Hygino da Cruz
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Aquaporin 4 ◽  
Neurologic Disease ◽  
Neurologic Complications ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Resonance Imaging ◽  
Imaging Characteristics ◽  
Spectrum Disorders ◽  
Post Infectious

Neurologic complications are being recognized as important outcomes of coronavirus disease 2019 (COVID-19). Pathogenesis is varied and incompletely understood, and may include neuroinvasion, indirect post-infectious neuroinflammation, and cerebrovascular pathologies. We present a case of COVID-19-related encephalomyeloradiculitis with clinical and magnetic resonance imaging characteristics of neuromyelitis optica spectrum disorders that was associated with anti-aquaporin-4 antibodies. Our case suggests post-infectious autoimmunity as a mechanism in at least a subset of patients with COVID-19-related neurologic disease.

Sudden onset of sleep due to hypothalamic lesions in neuromyelitis optica spectrum disorder positive for anti-aquaporin-4 antibody

2014 ◽  
Vol 20 (10) ◽  
pp. 1407-1408 ◽  
Author(s):  
H Okuma ◽  
K Matsumura ◽  
Y Hatanaka ◽  
F Saito ◽  
M Sonoo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Neuromyelitis Optica ◽  
Pulse Therapy ◽  
Sudden Onset ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Resonance Imaging ◽  
Spectrum Disorders ◽  
Aquaporin 4 Antibody

We report a patient with neuromyelitis optica spectrum disorders who presented with sudden onset of sleep as the sole manifestation. Magnetic resonance imaging investigation revealed lesions in the hypothalamus bilaterally, which vanished completely after methylprednisolone pulse therapy.

scholarly journals Case Report: Osmotic Demyelination Syndrome in an Adolescent with Neuromyelitis Optica

2018 ◽  
Vol 20 (3) ◽  
pp. 142-144 ◽  
Author(s):  
Sarah Kariv ◽  
Kathleen Bateman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Magnetic Resonance ◽  
Neuromyelitis Optica ◽  
Area Postrema ◽  
Imaging Features ◽  
Osmotic Demyelination Syndrome ◽  
Resonance Imaging ◽  
Osmotic Demyelination ◽  
Spectrum Disorders

A 17-year-old girl presented with intractable vomiting due to area postrema involvement in the first presentation of seronegative neuromyelitis optica (NMO). During the course of her illness, she developed mild hyponatremia, and magnetic resonance imaging revealed abnormalities consistent with the co-occurrence of osmotic demyelination syndrome (ODS). This combination of imaging features is novel, and this case expands the spectrum of brain abnormalities seen in NMO and NMO spectrum disorders. It was suspected that NMO may predispose to ODS by causing astrocyte dysfunction involving aquaporin 4 water channels, which are implicated in both conditions.

Seronegative neuromyelitis optica spectrum disorder patients diagnosed using new diagnostic criteria

2016 ◽  
Vol 22 (10) ◽  
pp. 1371-1375 ◽  
Author(s):  
Akiyuki Uzawa ◽  
Masahiro Mori ◽  
Tomohiko Uchida ◽  
Hiroki Masuda ◽  
Ryohei Ohtani ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diagnostic Criteria ◽  
Neuromyelitis Optica ◽  
Oligoclonal Bands ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Resonance Imaging ◽  
Protein Levels ◽  
Spectrum Disorders ◽  
Aqp4 Antibody

Background: Recently, new diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) were published. Objective: Our primary aim was to evaluate the usefulness of the new diagnostic criteria in anti-aquaporin 4 (AQP4) antibody-negative cases. Methods: Consecutive 471 patients whose anti-AQP4 antibody was measured at Chiba University were reviewed. Results: Four anti-AQP4 antibody negative-patients, who fulfilled the new diagnostic criteria for NMOSD but not 2006 diagnostic criteria for neuromyelitis optica (NMO), were identified. They showed high cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels, an absence of oligoclonal bands and/or cloud-like enhancement on magnetic resonance imaging, which are compatible findings for NMO. Conclusion: The new diagnostic criteria are clinically useful in seronegative NMOSD.

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