Aryl hydrocarbon receptor in mesenchymal stromal cells: new frontiers in AhR biology

FEBS Journal ◽  
2020 ◽  
Author(s):  
Kristopher K. Abney ◽  
Jacques Galipeau
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Aryl Hydrocarbon

scholarly journals Aryl hydrocarbon receptor signaling pathway plays important roles in the proliferative and metabolic properties of bone marrow mesenchymal stromal cells

2021 ◽  
Author(s):  
Yan Jia ◽  
Youshan Zhao ◽  
Zheng Zhang ◽  
Lei Shi ◽  
Ying Fang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Aryl Hydrocarbon Receptor ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Aryl Hydrocarbon ◽  
Receptor Signaling Pathway ◽  
Metabolic Properties

Abstract Bone marrow mesenchymal stromal cells (BMMSCs) are widely sourced and easily amplified in vitro; thus, they have a great potential in the treatment of hemopathies. Recent findings suggested that BMMSCs express the aryl hydrocarbon receptor (AHR). However, few studies have reported on the regulation of proliferative behaviors and metabolism by AHR in BMMSCs. In the present study, we found that activating AHR reduced the proliferation of BMMSCs and enhanced their mitochondrial function, whereas inhibiting AHR exerted the opposite effects. This study may provide the basis for further unveiling the molecular mechanisms and therapeutic potential of AHR in BMMSCs.

scholarly journals The IDO inhibitor 1-methyl tryptophan activates the aryl hydrocarbon receptor response in mesenchymal stromal cells

Oncotarget ◽  
2017 ◽  
Vol 8 (54) ◽  
pp. 91914-91927 ◽  
Author(s):  
Holly C. Lewis ◽  
Raghavan Chinnadurai ◽  
Steven E. Bosinger ◽  
Jacques Galipeau
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Aryl Hydrocarbon ◽  
Receptor Response

scholarly journals Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study

2003 ◽  
Vol 2 (1) ◽  
Author(s):  
Brenda A Jensen ◽  
Rebecca J Leeman ◽  
Jennifer J Schlezinger ◽  
David H Sherr
Keyword(s):  
Bone Marrow ◽  
Aryl Hydrocarbon Receptor ◽  
Stromal Cells ◽  
Interleukin 6 ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Aryl Hydrocarbon

Glycoengineering as a tool to control the behavior of bone marrow-derived mesenchymal stromal cells in biofabrication processes

2019 ◽  
Author(s):  
S Altmann ◽  
J Mut ◽  
N Wolf ◽  
J Bechold ◽  
F Jakob ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells

Mechanisms of action and osteogenic activity of bone marrow mesenchymal stromal cells are donor dependent

2014 ◽  
Author(s):  
Julie Leotot ◽  
Angelique Lebouvier ◽  
Philippe Hernigou ◽  
Helene Rouard ◽  
Nathalie Chevallier
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Mechanisms Of Action ◽  
Osteogenic Activity

Rankl-/- mesenchymal stromal cells have an unexpected osteogenic differentiation defect which is improved by a RANKL-expressing lentiviral vector

2016 ◽  
Author(s):  
Ciro Menale ◽  
Francesca Schena ◽  
Lorenzo Diomede ◽  
Lucia Sergi Sergi ◽  
Lucia Susani ◽  
...  
Keyword(s):  
Osteogenic Differentiation ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Lentiviral Vector
Sign in / Sign up

Export Citation Format

Share Document